DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and GUCY1A1

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens

Alignment Length:	513	Identity:	165/513 - (32%)
Similarity:	269/513 - (52%)	Gaps:	63/513 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DRVLSVLGRHMRDFLNGLDNLHEYLKFS--------YPRMRAPSFICENETKQGLTLHYRSKRRG 139
            :.:|.|:|..::||||....|   ||.|        ..|:...|.:|.::....|.::|...:|.
Human   149 ENILGVVGGTLKDFLNSFSTL---LKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRT 210

  Fly   140 FVYYTMGQIREVARYFYHKEMHI------------ELVREEILFDTVHVTFQLTFDNRAFTLASL 192
            ......|.|:..|...|..|:.:            |.|.:..|..:||:         ..|..||
Human   211 TSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHM---------KSTKPSL 266

  Fly   193 AMTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVIL--PELLGK-KITAWFDLVRPLI 254
            :.::.:..|.|...:..:.|||..:|..||.:...||.:..::  .:..|| ....:|:::.|.|
Human   267 SPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKI 331

  Fly   255 AFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKSLR---LKGQMVYMENWRMI 316
            ...|..|:...|..| :|.|    .|:|            :..:||.|   |||||:|:.....|
Human   332 NQTFSGIMTMLNMQF-VVRV----RRWD------------NSVKKSSRVMDLKGQMIYIVESSAI 379

  Fly   317 MFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVE--LKLALDQEQQKSKKLEESMR 379
            :|||:|.:..|......|||::|:.:|:..||::|.|.|...:  ||..|.   :....||::.:
Human   380 LFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLG---KLKATLEQAHQ 441

  Fly   380 LLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVS 444
            .|:||.::|.:||..:.|.:||.:|.:|:  :...:.|.:|::||||||.||.|||:.:|::|::
Human   442 ALEEEKKKTVDLLCSIFPCEVAQQLWQGQ--VVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVIT 504

  Fly   445 MLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPSTG 509
            ||||:|:.||:......|||||||||||.|..|...:...||.::..|||.|::...::..|. |
Human   505 MLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMALKMMELSDEVMSPH-G 568

  Fly   510 QHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLI 567
            :.:::|:|:|||:|.||:||:|||||||||:.|..|::.||.|:..|:::|.:|..|:
Human   569 EPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	22/100 (22%)
		HNOBA	201..404	CDD:311573	62/210 (30%)
		CYCc	383..571	CDD:214485	81/185 (44%)
		Herpes_ICP4_C	794..>955	CDD:332854
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	61/208 (29%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	71/156 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820