DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and GUCY1A2

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens

Alignment Length:	708	Identity:	201/708 - (28%)
Similarity:	327/708 - (46%)	Gaps:	150/708 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RRQAGIDSPSFSVHQV---YPENLLQKLAKKAQ----QVLGV--SERDF---------------- 65
            ||:..:||...|:.::   .|:.:.|.|.:..|    ||:|.  :|::|
Human    82 RRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSYADHSNKE 146

  Fly    66 ------------MDQMGVYFVGFVGQYG----------YDRVLSVLGRHMRDFLNGLDNLHEYLK 108
                        .:.:|:.|.....::|          .:|||..:|..::||.||.|.|.|:::
Human   147 EIEDVSGILQCTANILGLKFEEIQKRFGEEFFNICFHENERVLRAVGGTLQDFFNGFDALLEHIR 211

  Fly   109 FSYPR---MRAPSFICENETKQGLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVREEIL 170
            .|:.:   :.:|||:|:...:..|.|||........:..:|.|:...:..|..::.:|.|..|.|
Human   212 TSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKL 276

  Fly   171 FDTVHVTFQLTFDN------RAFTLASLAMTREEKHLP-----------ISAHVLFEIFPFCMVF 218
            ...|        .|      ..|.:.....|...|:||           ||.:.....|||.::|
Human   277 CSDV--------SNPGNCSCLTFLIKECENTNIMKNLPQGTSQVPADLRISINTFCRAFPFHLMF 333

  Fly   219 GADMVVRSIGNSLMVIL----PELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTE 279
            ...|.|..:|..|...|    .::|  |....|::|.|.:...|:.:|.|.:..|.:.|....:
Human   334 DPSMSVLQLGEGLRKQLRCDTHKVL--KFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEAS- 395

  Fly   280 RFDVQNEDLLQHEDGSE-PEKSLRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMH 343
                          ||| .:|.:.:||||:::.....|:|||:|.:..|..|:..||:::|:.:|
Human   396 --------------GSENKDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIH 446

  Fly   344 DFSRDLMLAGTQQSVE--LKLALDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRR 406
            |.:||::|.|.|...:  ||..:|   :....||.:.:.|:||.::|.:|||.:.|..||.:|.:
Human   447 DATRDVILVGEQAKAQDGLKKRMD---KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQ 508

  Fly   407 GENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDA 471
            |:..  ....||.|::||||||.||.||::.|||:|:||||.:|:.||.......:|||||||||
Human   509 GQQV--QARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDA 571

  Fly   472 YMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPS----------------------TGQHL-- 512
            |.|.||...|...||:.:..|||.|::...::..|.                      ..||.
Human   572 YCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSE 636

  Fly   513 ------RIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGPNY 571
                  ::|:|:|||:|:||:||::||||||||:.|..||:.||.|...::::|.:|       |
Human   637 TDLGTEKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT-------Y 694

  Fly   572 KIIERGEIDVKGKGTMGTYWLEERENRLPLQLTAA---LQVHPLSPVPPTPTPKTKAI 626
            ::::|.|     ..|......||..:..|.::...   |:|. ..|.||.|:..:..|
Human   695 QLLKREE-----SFTFIPRSREELPDNFPKEIPGICYFLEVR-TGPKPPKPSLSSSRI 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	40/187 (21%)
		HNOBA	201..404	CDD:311573	63/220 (29%)
		CYCc	383..571	CDD:214485	84/217 (39%)
		Herpes_ICP4_C	794..>955	CDD:332854
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002	26/110 (24%)
		HNOBA	316..503	CDD:285003	59/206 (29%)
		CYCc	485..705	CDD:214485	87/233 (37%)
		Guanylate_cyc	514..729	CDD:278633	80/226 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820