Protein Alignment Gyc88E and Gucy1b1

DIOPT Version :10

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_036901.2
• Gene: Gucy1b1 / 25202
• RGDID: 2769
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 630
• Identity: 222/630 - (35%)
• Similarity: 350/630 - (55%)
• Gaps: 55/630 - (8%)

  Fly     1 MYGLLLENLSEYIKSVYGEEKWEDIRRQAGIDSP-SFSVHQVYPENLLQKLAKKAQQVLGVSERD 64
            |||.:...|...:...||.|.||||:::|.:|.. .|.|..:|.::....|...|.:||.::..:
  Rat     1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGE 65

  Fly    65 FMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENETK-QG 128
            .:...|..|..|..:.|||.:|.|||.::|:||..||.||::|...||.||||||.|.:..| :|
  Rat    66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKG 130

  Fly   129 LTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVR---EEILFDTVHVTFQLTFDNRAFTLA 190
            |.|||.|:|.|.....:|.|:.||:..:..|:.:::::   ||.             |:..|.:.
  Rat   131 LILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRSEEC-------------DHTQFLIE 182

  Fly   191 SLAMTREE-------------KHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVILPELL-GK 241
            ......|:             :...||.:...:.|||.::|..|:||...||::..:||:|. ||
  Rat   183 EKESKEEDFYEDLDRFEENGTQDSRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGK 247

  Fly   242 -KITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKSLRLKG 305
             .:.:.|.||||.|...|..||:..|.:|.|.:.:.:.:...::.||.|   .|:| ...|||||
  Rat   248 CSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDEL---TGAE-ISCLRLKG 308

  Fly   306 QMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQK 370
            ||:|:.....|:||.:|.:.:|..|...|||::|:.:||.:|||:|.|.|...|.||..:.| ..
  Rat   309 QMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELE-IL 372

  Fly   371 SKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICS 435
            :.:|:.::|.|::|.::||.|||.::|..||:.||. :.|: ..:.:|:|:||||.||.|...||
  Rat   373 TDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRH-KRPV-PAKRYDNVTILFSGIVGFNAFCS 435

  Fly   436 RIT----PMEVVSMLNAMYSIFDKLTERNS---VYKVETIGDAYMVVAGAPDKDANHAERVCDMA 493
            :..    .|::|::||.:|:.||.||:...   ||||||:||.||.|:|.|:...:||..:|.:|
  Rat   436 KHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLA 500

  Fly   494 LDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVH 558
            |||::....::  ..|:.::|.:|:|:|.||.|::|.:||||||||:|||..||.|:|....|::
  Rat   501 LDMMEIAGQVQ--VDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKIN 563

  Fly   559 ISEST-KVLIG-----PNYKIIERGEIDVKGKGTMGTYWLEEREN 597
            :||.| :.|:.     |.:.:..||.:.:|||......|...|:|
  Rat   564 VSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKN 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..163	CDD:462233	60/162 (37%)
		HNOBA	201..404	CDD:462234	75/204 (37%)
		CYCc	383..571	CDD:214485	82/200 (41%)
		PHA03307	794..>955	CDD:223039
Gucy1b1	NP_036901.2	HNOB	2..166	CDD:462233	60/163 (37%)
		HNOBA	207..406	CDD:462234	75/203 (37%)
		Guanylate_cyc	412..605	CDD:425528	76/195 (39%)