DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and Npr1

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	721	Identity:	207/721 - (28%)
Similarity:	309/721 - (42%)	Gaps:	182/721 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ENLSE--YIKSVYGEEKWEDIRRQAGIDSPSFSVHQVYPE----NLLQKLAKKAQQVLGVSERDF 65
            ||:::  :.:|..|...:..|.|....|: .||:..:.||    .::......:|:::.|||...
  Rat   374 ENITQRMWNRSFQGVTGYLKIDRNGDRDT-DFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKL 437

  Fly    66 MDQMGVYFVGFVGQYGYDR-----------VLSVLGRHMRDFLNGLDNLHEYL---KFSYPRMR- 115
            ...:| |....|.:.|:|.           .|.||.      |.|..:|..:|   .|.|.:|:
  Rat   438 YWPLG-YPPPDVPKCGFDNEDPACNQDHFSTLEVLA------LVGSLSLISFLIVSFFIYRKMQL 495

  Fly   116 ----------------APSFICENETKQG--LTLHYRSKRRGFVYYTMGQIREVARYFYHK---- 158
                            .||.:..:....|  |||..|....|.:..|.||.:..|:..|:|
  Rat   496 EKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLV 560

  Fly   159 ------EMHIELVREEILFDTVHVTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMV 217
                  ...|||.| ::||:..|:.   ...|...|....|.|.     |.:..:|.|..|
  Rat   561 AVKRVNRKRIELTR-KVLFELKHMR---DVQNEHLTRFVGACTD-----PPNICILTEYCP---- 612

  Fly   218 FGADMVVRSIGNSLMVILPELLGKKITA-WF-------DLVRPLIAFKFQTILNRTN-------- 266
                      ..||..||.   .:.||. |.       |:|:.::......|.:..|
  Rat   613 ----------RGSLQDILE---NESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVV 664

  Fly   267 -NIFELVTVDPVTERF----DVQNEDLLQHEDGSEPE------------------------KSLR 302
             ..|.|...|...|.|    ..|...|...:..:.||                        :.:.
  Rat   665 DGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIA 729

  Fly   303 LKGQMVYMENWRMIMFLGTPVMP-DLTSLITTGLY---------------INDLSMHDFSRDLML 351
            |:..:.|:|        |..:.| ::...:|.|..               :..|....::.|...
  Rat   730 LRSGVFYVE--------GLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQE 786

  Fly   352 AGTQQSVELKL--------------ALDQEQQKSKKLEESMRLLD-------EEMRRTDELLYQM 395
            ....|.:.|.|              .|.:.:|.:..|||   |::       ||.|:.:.||||:
  Rat   787 RPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEE---LVEERTQAYLEEKRKAEALLYQI 848

  Fly   396 IPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERN 460
            :|..||::|:|||..  ..|.||||:|.|||||.||.:.:..|||:||::||.:|:.||.:.:..
  Rat   849 LPHSVAEQLKRGETV--QAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNF 911

  Fly   461 SVYKVETIGDAYMVVAGAPDKDAN-HAERVCDMALDMVDAITDLKDPSTGQ-HLRIRVGVHSGAV 523
            .||||||||||||||:|.|.::.. ||..|..|||.::||:...:.....| .||:|:|:|:|.|
  Rat   912 DVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPV 976

  Fly   524 VAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIG--PNYKIIERGEIDVKGKGT 586
            .||:|||||||||||||||||||||||...|:|:|:|..||.::.  ..:::..||::::||||.
  Rat   977 CAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGK 1041

  Fly   587 MGTYWL 592
            :.||||
  Rat  1042 VRTYWL 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	45/205 (22%)
		HNOBA	201..404	CDD:311573	52/284 (18%)
		CYCc	383..571	CDD:214485	100/191 (52%)
		Herpes_ICP4_C	794..>955	CDD:332854
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380	15/65 (23%)
		ANF_receptor	50..410	CDD:279440	9/36 (25%)
		PK_GC-A_B	530..803	CDD:270944	55/306 (18%)
		TyrKc	543..797	CDD:197581	51/287 (18%)
		HNOBA	<812..857	CDD:285003	16/47 (34%)
		CYCc	836..1025	CDD:214485	100/190 (53%)
		Guanylate_cyc	863..1049	CDD:278633	96/187 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810