DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	1274	Identity:	223/1274 - (17%)
Similarity:	383/1274 - (30%)	Gaps:	494/1274 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YGLLLENLSEYIKSVYGEEKWEDIRRQAG---------IDSPSFSVHQVYPENLLQKLAKKAQQV 57
            |.:..|.|:||       ::|:   |||.         :|...:|:.:| ||:|.
Mouse   258 YHVSFETLAEY-------QRWQ---RQASKVVSQRMSTVDLSCYSLEEV-PEHLF---------- 301

  Fly    58 LGVSERDFMDQMGVYFVGFVGQYGYDRVLSVLG-RHMRDFL-----NGLDNLHEY-----LKFSY 111
                                    |.:.::.|. ||  :|:     .|||.||::     |..|:
Mouse   302 ------------------------YSQDITYLNLRH--NFMQLERPGGLDTLHKFSQLKGLNLSH 340

  Fly   112 PRMRA-PSFICENETKQGLTL-----HYRSKRRGFVYY----------------TMGQIREVARY 154
            .::.. |..:||..|...|:|     |....:.|.:..                .:|.:|::...
Mouse   341 NKLGLFPVLLCEISTLTELSLSCNGFHDLPSQIGKLLNLQTLSLDGNGLTALPDELGNLRQLTSL 405

  Fly   155 ------FYH----------------------------------------KEMHIELVREEILFDT 173
                  |.|                                        :..|::.|..|.:...
Mouse   406 GISFNDFRHIPEVLEKLTMLDKVAMAGNRLEVLNLGALTRMSQVKHVDLRMNHLKTVITENMEGN 470

  Fly   174 VHVTFQLTFDNRA--FTLASLAMTREEKH------------------------------------ 200
            .|:|.....||:.  ..|:||. :.|:.|
Mouse   471 KHITHMDLRDNQLTDLDLSSLC-SLEQLHCERNQLRELTLSGFSLRTLYASWNRLTAVNVYPVPS 534

  Fly   201 ----LPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTI 261
                |.:|.::| |..|........:.:..|.::|:..:|             :|.|.:...:.:
Mouse   535 LLTSLELSQNLL-ECVPDWACEAKKLEILDISHNLLTEVP-------------MRILSSLSLRKL 585

  Fly   262 LNRTNNIFEL-VTVDPV-TERFDVQNEDLLQHEDGSEPEKSLRLKGQMVYM-------------- 310
            :...|:|..| ..|:.: .|..|:|:..|.:..| :...|:|.|:    |:
Mouse   586 MVGHNHIHVLPALVEHIPLEVLDIQHNTLSRLPD-TLFSKALNLR----YLNASANSLESLPSAC 645

  Fly   311 ---ENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSK 372
               |:..::..|      .|||.:.|...|..|..|...|.|.||..|...       ....|..
Mouse   646 AGEESLSVLQLL------YLTSNLLTDQCIPVLVGHPHLRVLHLANNQLQT-------FPASKLN 697

  Fly   373 KLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEI---- 433
            |||:.     ||:..:...| ..||..:|:           |:...::....::|..|.||
Mouse   698 KLEQL-----EELNLSGNKL-TAIPTTIAN-----------CKRLHTLVAHANNISIFPEILQLP 745

  Fly   434 --------CSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVC 490
                    |:.:|.:.:...|.|.....|.....|.|.:.:|
Mouse   746 QIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKT----------------------- 787

  Fly   491 DMALDMVDAITDLKD-----PSTGQHLRIRVGVHSGAVVAG------IVGLKMPR--------YC 536
               |||...||.||.     |:|...:......|..|.:||      :..|.|..        |.
Mouse   788 ---LDMFSHITALKIDQKPLPATDSAVTSTFWSHGLAEMAGQRNKLCVSALAMDNFAEGVGAVYG 849

  Fly   537 LF-GDTVNTASRMESTSIA--MKVHISESTK-VLIGPNYKIIERGEIDVKGKGTMGTYWL----- 592
            :| ||......|:...::|  :...:..||. .:...|..::...::.:.|: .:|:..|
Mouse   850 MFDGDRNEELPRLLQCTMADVLLEEVQHSTNDTVFMTNTFLVSHRKLGMAGQ-KLGSSALLCYIR 913

  Fly   593 -EERENRLPLQLTAALQVHPLSPV-----PPTPTPKT----------------KAIMPP------ 629
             :..:......||.| .|.....|     .|.|..|.                |||:..
Mouse   914 PDTADPTSSFSLTVA-NVGMCQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKDQKAIITEDNKVNG 977

  Fly   630 -----------------VSKPLTPMMPVSV--------SLAASMPTSNVPAV-------DVMASS 662
                             :.||.....|:::        :.|.....|.:.||       |.:|::
Mouse   978 VTCCTRLLGCTYLYPWILPKPHIASTPLTIQDELLILGNKALWEHLSYLEAVNAVRHVQDPLAAA 1042

  Fly   663 SSISGLALT-------AAAAAHMSLHHQAVVAE------------ALTGASVEVALPSVASGATG 708
            ..:..||.:       .|...::::..:....|            |.|.|..:...|:..|.::|
Mouse  1043 KKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTAALKDTPKPTTPSSSSG 1107

  Fly   709 AAAG--------------GGAPSDDRNSRIYSPVTFKDVARRSVANSPVRSCAQPDQERRRESRS 759
            .|:.              |...||:.|:                  ..:.:...|..|||.....
Mouse  1108 IASEFSSEMSTSEVSSEVGSTASDEHNT------------------VGLEASLLPRPERRCSLHP 1154

  Fly   760 NSTGHVFMRTPS-EIFGSLILDTEEFLEDLQISRSSLANNNNNQSP-----C-GFSPTPPFRIGS 817
            .|:..||.|.|| ..|.|...|.....:|.|.....:.|.:..:..     | |..|.      |
Mouse  1155 ASSAGVFQRQPSCATFSSNQSDNGLDSDDDQPVEGVITNGSRVEVEVDIHCCRGREPE------S 1213

  Fly   818 APPKPRPSNPDKFTPEELAAMDQLTPPSTAPARETASCSSASLDRDKATKLKKITFSNSSSLDAT 882
            :||.|:.|                   |.|.:.|.|..:...:.|..:.....:..:|...::.
Mouse  1214 SPPLPKNS-------------------SNACSEERARGAGFGIRRQNSVNSGILLPANRDKMEL- 1258

  Fly   883 TPTALAAVVCPMRTKSPPMAVAPVMHMVQASTSKGDGQR--PGS----KDSVSSISLHSPPPHRS 941
                         .|||             |||...|::  .||    :||::.|.:.:..|.|.
Mouse  1259 -------------QKSP-------------STSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRK 1297

  Fly   942 NSAPARPHSMSKAARKAFLAAKQTKAMEKLDKMIEEVQE 980
            ....|.|..:.  ....|:..:..:  |::.:.:::.||
Mouse  1298 TGYFAAPTQLE--PEDQFVVPRDLE--EEVKEQMKQHQE 1332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	40/249 (16%)
		HNOBA	201..404	CDD:311573	47/221 (21%)
		CYCc	383..571	CDD:214485	42/222 (19%)
		Herpes_ICP4_C	794..>955	CDD:332854	31/172 (18%)
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131	7/26 (27%)
		leucine-rich repeat	285..305	CDD:275380	7/54 (13%)
		leucine-rich repeat	306..332	CDD:275380	9/27 (33%)
		LRR_RI	309..548	CDD:238064	38/242 (16%)
		LRR_8	354..412	CDD:290566	7/57 (12%)
		leucine-rich repeat	356..378	CDD:275380	4/21 (19%)
		leucine-rich repeat	379..401	CDD:275380	1/21 (5%)
		leucine-rich repeat	402..424	CDD:275380	2/21 (10%)
		LRR_8	425..483	CDD:290566	7/57 (12%)
		leucine-rich repeat	425..448	CDD:275380	0/22 (0%)
		LRR_RI	447..714	CDD:238064	56/305 (18%)
		leucine-rich repeat	449..472	CDD:275380	3/22 (14%)
		leucine-rich repeat	474..493	CDD:275380	6/19 (32%)
		leucine-rich repeat	494..513	CDD:275380	2/18 (11%)
		leucine-rich repeat	514..535	CDD:275380	0/20 (0%)
		LRR_8	536..592	CDD:290566	11/69 (16%)
		leucine-rich repeat	536..558	CDD:275380	5/22 (23%)
		leucine-rich repeat	559..581	CDD:275380	5/34 (15%)
		leucine-rich repeat	582..597	CDD:275380	3/14 (21%)
		LRR_8	604..664	CDD:290566	14/70 (20%)
		leucine-rich repeat	604..627	CDD:275380	6/23 (26%)
		leucine-rich repeat	628..653	CDD:275380	3/28 (11%)
		leucine-rich repeat	654..677	CDD:275380	8/28 (29%)
		LRR_8	676..735	CDD:290566	16/82 (20%)
		leucine-rich repeat	678..701	CDD:275380	8/29 (28%)
		leucine-rich repeat	702..724	CDD:275380	7/38 (18%)
		leucine-rich repeat	747..768	CDD:275380	3/20 (15%)
		PP2Cc	816..1065	CDD:238083	41/250 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900