DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	XP_011243363.2	Gene:	Gucy1b2 / 239134	MGIID:	2660873	Length:	829	Species:	Mus musculus

Alignment Length:	699	Identity:	232/699 - (33%)
Similarity:	368/699 - (52%)	Gaps:	93/699 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGLLLENLSEYIKSVYGEEKWEDIRRQAGIDSPSFSVHQVYPENLLQKLAKKAQQVLGVSERDF 65
            |||.:...|...:...:|||.||.::..|.:.. .|..:.||.:.:..||.::|.:.|.||....
Mouse   114 MYGFINTCLQSLVTEKFGEETWEKLKASAEVQD-VFMTYTVYDDTITVKLIQEACKALDVSMEAI 177

  Fly    66 MDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENETKQGLT 130
            :...|.||..|....||||:|..||.::.:|:..||.||.||..||..|.||||..|......:.
Mouse   178 LKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEGGADGAMR 242

  Fly   131 LHYRSKRRGFVYYTMGQIREVARYFYHKEMHIEL--VREEI--LFDTVHVTFQL----------- 180
            |||.|.|||..:...|.|..||:.|:..::.:.:  :.||:  .....||.|.:
Mouse   243 LHYYSDRRGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKARRQIRGA 307

  Fly   181 ---------TFDNRAFTLASLAMTREEKHLPI------SAH------------------------ 206
                     ....:..:|....:.::|::|.|      .:|
Mouse   308 KVNRPRDSENIQAKQESLQGTLLRKKERYLSIPVCPGEKSHSAVVRASVLLGKGPLGDTFQPVFP 372

  Fly   207 --------VLFEIFPFCMVFGADMVVRSIGNSLMVILPELLGKK--ITAWFDLVRPLIAFKFQTI 261
                    |....|||.:||...:.|:..|.::...:|.:|.:|  :..:|.:|.|.:.|...:|
Mouse   373 ERLWIEEEVFCNAFPFHVVFDEALRVKQAGVNIQKYVPGILTQKFGLDEYFSIVHPQVTFNISSI 437

  Fly   262 LNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKSLRLKGQMVYMENWRMIMFLGTPVMPD 326
            ....|:.|.|.|           ..:::.....|:|  :|:|:|||::||:.:.::|:.:|.:..
Mouse   438 CKFINSQFILKT-----------RREMMPEAWKSQP--TLKLRGQMIWMESLKCMVFMCSPKLRS 489

  Fly   327 LTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDE----EMRR 387
            |..|..:.::::|::.||.:|||:|...|:..|::|:...|::|     |.:|:|..    |.::
Mouse   490 LQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKK-----EELRVLSNHLAIEKKK 549

  Fly   388 TDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSI 452
            |:.|||.|:|:.||::|:.|:..  ....|::.:|||||:||||.||:...|:::|:|||:|||.
Mouse   550 TETLLYAMLPEHVANQLKEGKKV--AAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSK 612

  Fly   453 FDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVG 517
            ||:||..:.||||||||||||||.|.|....:||:||.:.||.|..:..::.:|.||:.::||||
Mouse   613 FDRLTNIHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRVG 677

  Fly   518 VHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST-KVLIGPNYKIIERGEIDV 581
            :|:|.|:||:||.||||||||||||||||||||..:..|||:|.:. :.|....::|:.||||:|
Mouse   678 IHTGPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENKGFEIVTRGEIEV 742

  Fly   582 KGKGTMGTYWLEERENRLPLQL---TAALQVHPLSPVPPTPTPKTKAIM 627
            ||||.|.||:|....|...:::   .:||.....:..|.....|.:|::
Mouse   743 KGKGKMTTYFLIRNLNATEVEIMGRPSALADGKEASTPRNQVKKPRAVL 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	56/161 (35%)
		HNOBA	201..404	CDD:311573	60/246 (24%)
		CYCc	383..571	CDD:214485	97/192 (51%)
		Herpes_ICP4_C	794..>955	CDD:332854
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167	56/161 (35%)
		HNOBA	380..566	CDD:400168	57/203 (28%)
		Guanylate_cyc	572..754	CDD:306677	99/183 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2973
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5138
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto92851
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5317
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.760