DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001028494.1	Gene:	Gucy1a2 / 234889	MGIID:	2660877	Length:	730	Species:	Mus musculus

Alignment Length:	655	Identity:	201/655 - (30%)
Similarity:	330/655 - (50%)	Gaps:	81/655 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLENLSEYIKSVYG----EEKWEDIRRQAGIDSPSFSVHQVYPE-----NLLQKLAKKAQQVLGV 60
            |...|..|...|.|    |:.:.:|.::.     |::.|....|     .:||..|    .|||:
Mouse   107 LKRTLQYYEHQVIGYRDAEKNFHNISKRC-----SYADHSNKEEIEDVSGILQCTA----NVLGL 162

  Fly    61 SERDFMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPR---MRAPSFICE 122
            ..::..::.|..|........ :|||..:|..::||.||.|.|.|:::.|:.:   :.:.||:|:
Mouse   163 QFQEIQERFGEEFFKICFDEN-ERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESSSFLCK 226

  Fly   123 NETKQGLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELV-REEILFDTVH------VTF-- 178
            ...:..|.|||........:..:|.|:...:..||..:.:|.: .|::.||..:      :||
Mouse   227 ELPEGTLMLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEKLCFDGSNPSNCSCLTFLI 291

  Fly   179 ------QLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVIL-- 235
                  |:|.||...|      ::....|.||.:.....|||.::|.::|||..:|..|...|
Mouse   292 KECETTQITKDNPQGT------SQVPADLRISINTFCRAFPFHLMFDSNMVVLQLGEGLRKQLRY 350

  Fly   236 PELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKS 300
            ......|....|::|.|:|...|..:|.|.:..| ::...|  |....:|||           |.
Mouse   351 DTHRALKFEDCFEIVSPMINATFDRVLLRLSTPF-VIRTKP--EASGTENED-----------KV 401

  Fly   301 LRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVE--LKLA 363
            :.:||||:::.....|:|||:|.:..|..|:..||:::|:.:||.:||::|.|.|...:  ||..
Mouse   402 MEIKGQMIHVPESSAILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKR 466

  Fly   364 LDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIV 428
            :|   :....||.:.:.|:||.::|.:|||.:.|..||.:|.:|:..  ....||.|::||||||
Mouse   467 MD---KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQV--QARKFDDVTMLFSDIV 526

  Fly   429 TFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMA 493
            .||.||::.|||:|:||||.:|:.||.......:||||||||||.|.:|...|...||:.:..||
Mouse   527 GFTAICAQCTPMQVISMLNELYTRFDHQCGLLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMA 591

  Fly   494 LDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVH 558
            |.|::...::..|. |:.:::|:|:|||:|:||:||::||||||||:.|..||:.||.|...:::
Mouse   592 LKMMELSEEVLTPD-GKAIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRIN 655

  Fly   559 ISESTKVLIGPNYKIIERGEIDVKGKGTMGTYWLEERENRLPLQLTAALQVHPL--SPVPPTPTP 621
            :|.:|       |::::|     :...|......||..:..|.::........|  .|.||.|:.
Mouse   656 VSPTT-------YQLLKR-----EDSFTFIPRSREELPDNFPKEIPGVCYFLELRTDPKPPKPSL 708

  Fly   622 KTKAI 626
            .:..|
Mouse   709 SSSRI 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	41/170 (24%)
		HNOBA	201..404	CDD:311573	64/206 (31%)
		CYCc	383..571	CDD:214485	82/187 (44%)
		Herpes_ICP4_C	794..>955	CDD:332854
Gucy1a2	NP_001028494.1	HNOB	<157..268	CDD:285002	29/115 (25%)
		HNOBA	314..501	CDD:285003	62/203 (31%)
		CYCc	483..672	CDD:214485	84/203 (41%)
		Guanylate_cyc	512..696	CDD:278633	77/196 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820