DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and gcy-34

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_506319.1	Gene:	gcy-34 / 191656	WormBaseID:	WBGene00001554	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	635	Identity:	184/635 - (28%)
Similarity:	322/635 - (50%)	Gaps:	50/635 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGLLLENLSEYIKSVYGEEKWEDIRRQAGIDSPSFS-VHQVYPENLLQKLAKKAQQVLGVSERD 64
            |:|.:.|::.:.:...|||:.|..:..::|.::...: |:..|.:.....|......||.|::..
Worm     1 MFGFIHESIRQLVIRKYGEDVWLQVLERSGFENGKENIVNHYYSDTDTYVLVDSVSIVLKVTKDQ 65

  Fly    65 FMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSY--PRMRAPSFICENETKQ 127
            ..:..|.:.:.:..:.|:|.::..:..:::.||:.||:||.::....  ..:|.|||.||.....
Worm    66 IWEMYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCEENPDG 130

  Fly   128 GLTLHYRSKRRGFVYYTMGQIREVARYFYH------------KEMHI---ELVREEILFDTVHVT 177
            .|.|||.:.|.|..:...|.::|||:..::            :.:|:   |.|.|.::|...:|.
Worm   131 TLMLHYFTGRPGLYHIVKGVVKEVAKLVFNLDISLVVQGRTQRSVHMNNGERVEEHVIFLIKNVE 195

  Fly   178 FQLTFDNRAFTLASLAMTRE------EKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVILP 236
             :...|:...|.::|.....      :.:|.:|........|:..|......:...|:.|...:|
Worm   196 -EPRRDSDTSTTSALTSVEPDFGEIIDDNLKVSLQDFSRALPYHFVLDESCRLVQCGDELYNHIP 259

  Fly   237 -ELL--GKKITAWFDLVRPLIAFKFQTILNRTNNIFEL-VTVDPVTERF--DVQNEDLLQHEDGS 295
             |||  |..|...|::.||.|...|:.|.|..|.:|.| |...|:.::.  .:..|:..|..:..
Worm   260 NELLQPGTPILRIFEINRPQIPLDFENICNFINAVFVLQVKTSPLRKKHMNAMTKEEREQEVEAM 324

  Fly   296 EPEKS---------LRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLML 351
            |.|..         |:|||||:.:...:.|::|.:|.:..:..|:..|:.:..:.:||.:|||:|
Worm   325 EEEVESNELTQGCHLKLKGQMMMLSTKKHIIYLCSPYVTSINELMQFGMRLTAMPLHDATRDLIL 389

  Fly   352 AGTQQ--SVELKLALDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTC 414
            ...|:  .||:.|.|   :..:::||.....|:.|.::||.:|..|:|:::|.:|..||: ::.|
Worm   390 LNQQRLSDVEVNLQL---EANNEQLETMTHELEVERQKTDSILKDMLPRKIAKQLLSGEH-LEPC 450

  Fly   415 EMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAP 479
            |.  ..:::|.|:..|.:|.....|..:|.:||.::...|::.....||||||:.|:||.|:|.|
Worm   451 EY--EATVMFCDLPAFQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRGVYKVETVSDSYMTVSGIP 513

  Fly   480 DKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNT 544
            |..:.|||.:|.:||.|:.....:.||.......:|:|:|||.::||:||.|||||||||:||..
Worm   514 DYTSEHAENMCHVALGMMWEARSVMDPVNKTPFLLRIGLHSGTIIAGVVGTKMPRYCLFGETVTL 578

  Fly   545 ASRMESTSIAMKVHISEST--KVLIGPNYKIIERGEIDVKGKGTMGTYWL 592
            ||:|||..:|.|:..|..|  |.:....::...||.|:|||:|.:.||:|
Worm   579 ASQMESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYFL 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	39/179 (22%)
		HNOBA	201..404	CDD:311573	60/219 (27%)
		CYCc	383..571	CDD:214485	73/189 (39%)
		Herpes_ICP4_C	794..>955	CDD:332854
gcy-34	NP_506319.1	HNOB	3..167	CDD:285002	38/163 (23%)
		HNOBA	224..441	CDD:285003	60/219 (27%)
		CYCc	421..609	CDD:214485	73/190 (38%)
		Guanylate_cyc	453..629	CDD:278633	71/176 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5317
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.810