DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and gcy-25

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001294116.1	Gene:	gcy-25 / 191653	WormBaseID:	WBGene00001549	Length:	1034	Species:	Caenorhabditis elegans

Alignment Length:	262	Identity:	94/262 - (35%)
Similarity:	149/262 - (56%)	Gaps:	11/262 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 INDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKL-EESMRLLDEEMRRTDELLYQMIPKQV 400
            |.|....:|.:|:......|.:|:   :|:.....::: .|..|.|:::|..|:.||||::||.|
Worm   741 ITDAVNREFGQDVKGTLIDQMIEM---IDEYSANLEQIVAERTRELEQDMSVTENLLYQLLPKSV 802

  Fly   401 ADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKV 465
            ||.:|.|:..:.  |...||::|..|:..||:.|....|:.::..|..:||.||.:.::|..:||
Worm   803 ADSIRSGKTVVP--EQHSSVTLLVVDVCQFTKFCEAFIPVHILETLQELYSSFDNIVQKNKAFKV 865

  Fly   466 ETIGDAYMVVAGAPDKDA-NHAERVCDMALDMVDAITDLKDPSTGQH-LRIRVGVHSGAVVAGIV 528
            |.:||||::.:|.|:... .|...:|.::|.:...:...|......| |:|::|:.||||.|||:
Worm   866 ENVGDAYLICSGIPEMSGFRHLREICKISLKLQAFMKTFKVRHRPSHTLQIKMGITSGAVAAGIL 930

  Fly   529 GLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLI---GPNYKIIERGEIDVKGKGTMGTY 590
            |...||:|:||||||.|.||.||.....:.:||.|...:   .|::.:.|||.|||||||...|:
Worm   931 GSTAPRFCIFGDTVNMACRMASTGNPGSIQLSELTANTLMEKFPSFMLEERGMIDVKGKGACLTF 995

  Fly   591 WL 592
            ||
Worm   996 WL 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	21/67 (31%)
		CYCc	383..571	CDD:214485	71/192 (37%)
		Herpes_ICP4_C	794..>955	CDD:332854
gcy-25	NP_001294116.1	PBP1_iGluR_N_LIVBP_like	56..>230	CDD:107346
		PKc_like	473..746	CDD:304357	2/4 (50%)
		SPS1	474..>736	CDD:223589
		HNOBA	<764..805	CDD:285003	14/43 (33%)
		CYCc	790..976	CDD:214485	70/187 (37%)
		Nucleotidyl_cyc_III	812..999	CDD:299850	71/188 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810