Protein Alignment Gyc88E and gcy-5

DIOPT Version :9

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_496219.1
• Gene: gcy-5 / 191643
• WormBaseID: WBGene00001532
• Length: 1122
• Species: Caenorhabditis elegans
• Alignment Length: 581
• Identity: 170/581 - (29%)
• Similarity: 264/581 - (45%)
• Gaps: 147/581 - (25%)

  Fly   101 DNLHEYLKFSYPRMRAPSFI-----CENETKQGLTLHYRSKRRGFVYYTMGQIREVAR--YFYHK 158
            |||::::..|   :..|.|:     |...:.|.:.........||..:.:  |.::|.  .|.||
 Worm   608 DNLNKFIGLS---IDGPQFVAVWKMCSRGSLQDIIARGNFSMDGFFMFCI--ITDIAEGMNFLHK 667

  Fly   159 ---EMHIELVREEILFDTVHVTFQLTFDNRAFTLASLAMTREEKHLPISAHVLF---EIFPFCMV 217
               .:|..|.....|   |:.::|:...:  |.|.:|.    |:|.|....:|:   |:....:.
 Worm   668 SFLHLHGNLRSATCL---VNDSWQVKLTD--FGLGALL----EEHTPSKKRLLWAAPEVLRGSLT 723

  Fly   218 F-----GADMVVRSIGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELV----- 272
            .     .||:.      |..:|..|:|.|: .||             .|.||.....|::
 Worm   724 IHQMDPSADVY------SFAIIASEILTKR-EAW-------------DISNRKEGADEILYMVKK 768

  Fly   273 ----TVDP-------VTERFDVQNEDLL--QHEDGSEPEKSLRLKGQMVYMENWRMIMFLGTPVM 324
                |:.|       |:.|.....:|..  |.||..:.|:..:|..:|....|
 Worm   769 GGNRTIRPELILDAEVSPRLTTLVKDCWSEQPEDRPKAEQICKLLSEMTPRGN------------ 821

  Fly   325 PDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRTD 389
                         .:|..|.|:   ||.....::|:            .:||..:.|..|.::.|
 Worm   822 -------------TNLMDHVFN---MLEEYTSTLEV------------DIEERTKELTLEKKKAD 858

  Fly   390 ELLYQMIPKQVADRLRRGE--NPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSI 452
            .||.:|:|||||:||:.|:  .|    |.||:|::||||:|.||::.::.:|.:||::||.:||.
 Worm   859 ILLSRMLPKQVAERLKAGQTVEP----EGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYSN 919

  Fly   453 FDKLTERNSVYKVETIGDAYMVVAGAPDKDA-NHAERVCDMALDMVDAITDLKDPSTGQHL---- 512
            ||.:.|.:.|||||:|||.|:.|:|.|.|:. .|.:::.||:|..:|.....|.|    ||
 Worm   920 FDTIIEEHGVYKVESIGDGYLCVSGLPTKNGYAHIKQIVDMSLKFMDYCKSFKVP----HLPREK 980

  Fly   513 -RIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGPN----YK 572
             .:|:|::||..|||:|||.|||||||||||||||||||......:|:||:...|:..:    |:
 Worm   981 VELRIGINSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLTDHYPHQYE 1045

  Fly   573 IIERGEIDVKGKGTMGTYW-----------LEER------ENRLPLQLTAALQVHPLSPVP 616
            ...|||:.:||||.|.|:|           |..|      :...|.|:...|:...::|.|
 Worm  1046 TSSRGEVIIKGKGVMETFWVLGKTDSDTKSLSTRTTPPITDENWPPQMKEDLKKRAVTPYP 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	16/72 (22%)
		HNOBA	201..404	CDD:311573	47/228 (21%)
		CYCc	383..571	CDD:214485	90/199 (45%)
		Herpes_ICP4_C	794..>955	CDD:332854
gcy-5	NP_496219.1	PBP1_NPR_GC_like	30..440	CDD:107347
		ANF_receptor	49..426	CDD:279440
		PK_GC	546..816	CDD:270894	51/241 (21%)
		HNOBA	<830..873	CDD:285003	16/57 (28%)
		CYCc	852..1042	CDD:214485	90/197 (46%)
		Guanylate_cyc	879..1067	CDD:278633	88/195 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810