Protein Alignment Gyc88E and gcy-1

DIOPT Version :10

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_496039.1
• Gene: gcy-1 / 191639
• WormBaseID: WBGene00001528
• Length: 1137
• Species: Caenorhabditis elegans
• Alignment Length: 638
• Identity: 182/638 - (28%)
• Similarity: 273/638 - (42%)
• Gaps: 182/638 - (28%)

  Fly    23 EDIRRQAG--IDSPSF-SVHQVYPENLLQKLAKKAQQVLGVSERDF-MDQMGVYFVGFVGQYGYD 83
            |:|.|..|  |||..| ||.::.....||.:         :|..:| ||    ||..|.
 Worm   617 ENINRFIGLSIDSAHFISVTKLCSRGSLQDI---------LSRGNFSMD----YFFMFC------ 662

  Fly    84 RVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENETKQGLTLHYRSKRRGFVYYTMGQI 148
                    .:||...||:.||                     |..|.||             |.:
 Worm   663 --------IIRDVAKGLEYLH---------------------KTFLRLH-------------GNL 685

  Fly   149 REVARYFYHKEMHIELVREEILFDTVHVTFQLTFDNRAFTLA------SLAMTREEKHLPISAHV 207
            |. |....:....::|.  |...|.: |..|.....|...:|      ||::::.|.
 Worm   686 RS-ATCLVNDSWQVKLA--EYGMDNL-VEEQTPPKKRLLWVAPEVLRGSLSVSQMEP-------- 738

  Fly   208 LFEIFPFCMVFGADMVVRSIGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELV 272
                       .||:.      |..:|..|:|.|| .||             .||:|..:..|:|
 Worm   739 -----------SADIY------SFAIIASEILTKK-EAW-------------DILDRKEDCEEIV 772

  Fly   273 ---------TVDP--VTERFDVQNEDLLQHED--GSEPEKSLRLKGQMVYMENWRMIMFLGTPVM 324
                     .:.|  :|:..||....:...:|  ...||.  |...:.:..:            |
 Worm   773 YNVKKGGLFPIRPEIITDIHDVNPALIALVKDCWAEVPED--RPTAENICSQ------------M 823

  Fly   325 PDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRTD 389
            ..|.|...|.|..:..:|.:              |....|::|      :||..:.|..|.::.|
 Worm   824 KGLVSKQKTNLMDHVFNMLE--------------EYTSTLEEE------IEERTKELTLEKKKAD 868

  Fly   390 ELLYQMIPKQVADRLRRGE--NPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSI 452
            .||.:|:|||||:||:.|:  .|    |.||||::.|||:|.||.:.|:.:|.:.|::||.:||.
 Worm   869 ILLSRMLPKQVAERLKAGQTVEP----EGFDSVTVFFSDVVKFTILASKCSPFQTVNLLNDLYSN 929

  Fly   453 FDKLTERNSVYKVETIGDAYMVVAGAPDKDA-NHAERVCDMALDMVDAITDLKDPS-TGQHLRIR 515
            ||.:.|::.|||||:|||.|:.|:|.|.::. .|.:::.||:|..::.......|. ..:::.:|
 Worm   930 FDTIIEQHGVYKVESIGDGYLCVSGLPTRNGYAHIKQIVDMSLKFMEYCKSFNIPHLPRENVELR 994

  Fly   516 VGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIG---PN-YKIIER 576
            :||:||..|||:|||.|||||||||||||||||||......:|::.....|:.   || |:...|
 Worm   995 IGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTNDAHSLLTTHYPNQYETSSR 1059

  Fly   577 GEIDVKGKGTMGTYWLEERENRL-PLQLTAALQVHPLSPVPPT-----PTPKT 623
            ||:.:||||.|.|:|:..|...: |.:|.:   :...|..|.|     |.|.:
 Worm  1060 GEVIIKGKGVMETFWVHGRFGEMEPTELRS---ISNRSTPPVTNDRWIPNPSS 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..163	CDD:462233	32/143 (22%)
		HNOBA	201..404	CDD:462234	45/215 (21%)
		CYCc	383..571	CDD:214485	86/195 (44%)
		PHA03307	794..>955	CDD:223039
gcy-1	NP_496039.1	PBP1_NPR_GC-like	35..451	CDD:380575
		Protein Kinases, catalytic domain	555..821	CDD:473864	65/309 (21%)
		HNOBA	<839..883	CDD:462234	17/63 (27%)
		CYCc	862..1051	CDD:214485	84/192 (44%)