DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and gcy-1

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_496039.1	Gene:	gcy-1 / 191639	WormBaseID:	WBGene00001528	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	638	Identity:	182/638 - (28%)
Similarity:	273/638 - (42%)	Gaps:	182/638 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EDIRRQAG--IDSPSF-SVHQVYPENLLQKLAKKAQQVLGVSERDF-MDQMGVYFVGFVGQYGYD 83
            |:|.|..|  |||..| ||.::.....||.:         :|..:| ||    ||..|.
Worm   617 ENINRFIGLSIDSAHFISVTKLCSRGSLQDI---------LSRGNFSMD----YFFMFC------ 662

  Fly    84 RVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENETKQGLTLHYRSKRRGFVYYTMGQI 148
                    .:||...||:.||                     |..|.||             |.:
Worm   663 --------IIRDVAKGLEYLH---------------------KTFLRLH-------------GNL 685

  Fly   149 REVARYFYHKEMHIELVREEILFDTVHVTFQLTFDNRAFTLA------SLAMTREEKHLPISAHV 207
            |. |....:....::|.  |...|.: |..|.....|...:|      ||::::.|.
Worm   686 RS-ATCLVNDSWQVKLA--EYGMDNL-VEEQTPPKKRLLWVAPEVLRGSLSVSQMEP-------- 738

  Fly   208 LFEIFPFCMVFGADMVVRSIGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELV 272
                       .||:.      |..:|..|:|.|| .||             .||:|..:..|:|
Worm   739 -----------SADIY------SFAIIASEILTKK-EAW-------------DILDRKEDCEEIV 772

  Fly   273 ---------TVDP--VTERFDVQNEDLLQHED--GSEPEKSLRLKGQMVYMENWRMIMFLGTPVM 324
                     .:.|  :|:..||....:...:|  ...||.  |...:.:..:            |
Worm   773 YNVKKGGLFPIRPEIITDIHDVNPALIALVKDCWAEVPED--RPTAENICSQ------------M 823

  Fly   325 PDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRTD 389
            ..|.|...|.|..:..:|.:              |....|::|      :||..:.|..|.::.|
Worm   824 KGLVSKQKTNLMDHVFNMLE--------------EYTSTLEEE------IEERTKELTLEKKKAD 868

  Fly   390 ELLYQMIPKQVADRLRRGE--NPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSI 452
            .||.:|:|||||:||:.|:  .|    |.||||::.|||:|.||.:.|:.:|.:.|::||.:||.
Worm   869 ILLSRMLPKQVAERLKAGQTVEP----EGFDSVTVFFSDVVKFTILASKCSPFQTVNLLNDLYSN 929

  Fly   453 FDKLTERNSVYKVETIGDAYMVVAGAPDKDA-NHAERVCDMALDMVDAITDLKDPS-TGQHLRIR 515
            ||.:.|::.|||||:|||.|:.|:|.|.::. .|.:::.||:|..::.......|. ..:::.:|
Worm   930 FDTIIEQHGVYKVESIGDGYLCVSGLPTRNGYAHIKQIVDMSLKFMEYCKSFNIPHLPRENVELR 994

  Fly   516 VGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIG---PN-YKIIER 576
            :||:||..|||:|||.|||||||||||||||||||......:|::.....|:.   || |:...|
Worm   995 IGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSLIHLTNDAHSLLTTHYPNQYETSSR 1059

  Fly   577 GEIDVKGKGTMGTYWLEERENRL-PLQLTAALQVHPLSPVPPT-----PTPKT 623
            ||:.:||||.|.|:|:..|...: |.:|.:   :...|..|.|     |.|.:
Worm  1060 GEVIIKGKGVMETFWVHGRFGEMEPTELRS---ISNRSTPPVTNDRWIPNPSS 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	32/144 (22%)
		HNOBA	201..404	CDD:311573	45/215 (21%)
		CYCc	383..571	CDD:214485	86/195 (44%)
		Herpes_ICP4_C	794..>955	CDD:332854
gcy-1	NP_496039.1	PBP1_NPR_GC_like	35..449	CDD:107347
		ANF_receptor	53..432	CDD:279440
		PKc_like	555..821	CDD:304357	65/309 (21%)
		HNOBA	<840..883	CDD:285003	17/62 (27%)
		CYCc	862..1051	CDD:214485	84/192 (44%)
		Guanylate_cyc	889..1077	CDD:278633	84/191 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810