DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and phlp-2

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	1115	Identity:	196/1115 - (17%)
Similarity:	349/1115 - (31%)	Gaps:	388/1115 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 NLLQKLAKKAQQVLGVSERDFMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKF 109
            |:|:....:||||...:..|..|:.                |:::...:         |:...:.
Worm   215 NILEAWLTRAQQVEKSNHVDASDEQ----------------LTLIPEQI---------LNNEARV 254

  Fly   110 SYPRMRAPSFICENETKQGLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVREEILFDTV 174
            ....:|..|.|....|::.:.             .:|.|.::  |..|....|:|...:||...:
Worm   255 QILNLRRNSLISRPPTEKSMA-------------PLGYIDDL--YRVHSLQVIDLSANQILSFPI 304

  Fly   175 HVTF-----QLTF------------------------DNRAFTLA-SLAMTREEKHLPISAHVLF 209
            .:|.     ||..                        :|:..||. |::..:..:.|.||.:...
Worm   305 QLTLLSHLRQLNLSSNYISSVPSECSNMRRLQYLNLSNNQLDTLPDSISELQNLQSLDISFNQFS 369

  Fly   210 EIFPFCMVFGADMVVRSIGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTV 274
            :| |.|:......:.|..||::..|  :.:|:......||.|.::...|
Worm   370 QI-PPCLFHLTLEMWRLAGNNIEKI--DRVGEMQIQKIDLRRNVLDTSF---------------- 415

  Fly   275 DPVTERFDVQNEDLLQHEDGSEPE--------------------KSLRLKGQM---VYMENWRMI 316
                 |.|::|...|...|.|...                    .||.|.|:.   ||.::..:.
Worm   416 -----RLDIENITHLDLRDNSMISTVHLTNLRFLKVIHCERLQLSSLHLSGESLTHVYADHNLLD 475

  Fly   317 MFLGTPVMPDLTSLITTGLYINDL-SMHDFSRD----LMLAGTQQSVELKLALDQEQQKSKKLEE 376
            ..:   |||...:|.|..|..|.. ::.|:..|    ..|.....|:   :||.:....|:.|..
Worm   476 SLV---VMPLPQNLQTLSLSFNHFRNLPDWISDCPNLTFLRANNNSL---VALPERIFYSQSLRS 534

  Fly   377 SMRLLDEEMRRTD---------ELLYQ----MIPK---QVADRLRR---GENPIDTCEMFDSVSI 422
            ....::|.....|         .:||:    .:||   .:..|||:   ..|.|:....||..|.
Worm   535 IFAFINEIEHIPDFGEENCLETLILYKNKLSSLPKHFFSILPRLRQLNISSNFIELLPYFDGSSF 599

  Fly   423 LFSDIVT-----FTE----ICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGA 478
            ....|:.     .||    :...:..::::.:.:...:.||.    :::..:|.:.|..:
Worm   600 CRLQILRCANNYLTENSVPVIVNMKHLKIIDLSHNRLNSFDD----SALSSLELLEDLNL----- 655

  Fly   479 PDKDANHAERVCDMALDMVDAITDLKDPSTGQHLRI----------RVGVHSGAVVAGIVGLKMP 533
               .:|...|:.| .|.::..:..|:..| .|.:.:          .:.|.|..:..|.:..|.|
Worm   656 ---SSNRLTRLAD-CLALLPCLQVLRAHS-NQLVHVPEFRASNQLHTIDVSSNNISLGTLQFKAP 715

  Fly   534 ---RY----CLFG--DTVNTASRMESTSIAMKVHISESTKVLIGPNYKIIERGEIDVKGK----- 584
               |:    |..|  ||.|.....:..|....::|||.::.|.|  ::|...|...:|.|
Worm   716 PNLRHFDVTCNSGDFDTENFPENAKMHSKMNTINISEGSQNLFG--FQIGVSGSRGMKNKQCIRQ 778

  Fly   585 ----GTMGTYWLEERENRLPLQLTAALQVHPLSPVPPTPTPKTKAIMPPVSKPLTPMMPVSVSLA 645
                .|.|  :::...|                          ..:...:.:.:|..:..:||:
Worm   779 VRVENTFG--FIDGGSN--------------------------SYMSSSICRFMTSYLKENVSM- 814

  Fly   646 ASMPTSNVPAVDVMASSSSISGLALTAAAAAHMSLHHQAVVAEALTGASV------EVALPSVAS 704
                              .|..:.|    ..|..|..:   .|.| ||||      |..|...::
Worm   815 ------------------DIRSILL----RCHCELGEE---GERL-GASVMIIRVHEKRLEIAST 853

  Fly   705 GATGAAA-----------GGGAPSDDRNSRIYSPVTFKDVARRSVANSPVRSCAQPDQERRRESR 758
            |...||.           |.....||..|||.....|.|...|  .|..:.|
Worm   854 GTMSAAIARNQKLKMIINGRYEIDDDEYSRIREAHGFVDEENR--INGVIGS------------- 903

  Fly   759 SNSTGHVFMRTPSEIFGSLILDTEEF--------LEDLQISRSSLANN----------NNNQSPC 805
            |...|| |...|      ::|.|..:        :|.|.:..:.:.|.          :||:||.
Worm   904 SRQIGH-FSTFP------VVLPTHSYRNIQLNEQIEGLIVGNNMIWNMLSIDDLNSTFHNNRSPI 961

  Fly   806 GFSPTPPFRIGSAPPKPRPSNPDKFTPEELAAMDQLTPPSTAPARETASCSSASLDRDKATKLKK 870
                     :.:...:.:..:.|......:..:.::.|..|...
Worm   962 ---------VVAKKIQDQLQSYDYGGNSNILVLRRIKPQMTFNG--------------------- 996

  Fly   871 ITFSNSSSLDATTP------------TALAAVVCPMRTKSPPMAVAPVMHMVQASTSKGDGQRPG 923
              ||.||:.:..||            .|:.|::.|....|||  |.|.:..::..|..
Worm   997 --FSTSSTKNQVTPDIAIPKIDEQLVLAVPALILPEYHPSPP--VPPPIPAIRHRTPS------- 1050

  Fly   924 SKDSVSSISLHSPPPHRSNSAP---ARPHSMSKAARKAFLAAKQTKAMEKL---------DKMIE 976
                       .|||...:|.|   :..|......:.:.|:...|.::::.         .|...
Worm  1051 -----------PPPPPLPSSTPPPVSSEHEEINVRQSSTLSGGYTLSIDRFYSSSSTVSSRKQFN 1104

  Fly   977 EVQEVESQSV 986
            |.:::.|:|:
Worm  1105 ETRDLLSKSL 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	19/118 (16%)
		HNOBA	201..404	CDD:311573	48/246 (20%)
		CYCc	383..571	CDD:214485	45/234 (19%)
		Herpes_ICP4_C	794..>955	CDD:332854	29/185 (16%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	4/45 (9%)
		leucine-rich repeat	254..288	CDD:275380	7/48 (15%)
		PLN00113	283..>718	CDD:331614	88/480 (18%)
		leucine-rich repeat	289..311	CDD:275380	5/21 (24%)
		leucine-rich repeat	312..334	CDD:275380	2/21 (10%)
		leucine-rich repeat	335..357	CDD:275380	4/21 (19%)
		leucine-rich repeat	358..379	CDD:275380	6/21 (29%)
		leucine-rich repeat	380..440	CDD:275380	15/82 (18%)
		leucine-rich repeat	441..485	CDD:275380	9/46 (20%)
		leucine-rich repeat	486..508	CDD:275380	6/21 (29%)
		leucine-rich repeat	509..534	CDD:275380	6/27 (22%)
		leucine-rich repeat	554..577	CDD:275380	4/22 (18%)
		leucine-rich repeat	578..602	CDD:275380	7/23 (30%)
		leucine-rich repeat	603..625	CDD:275380	3/21 (14%)
		leucine-rich repeat	626..649	CDD:275380	2/26 (8%)
		leucine-rich repeat	650..672	CDD:275380	5/30 (17%)
		leucine-rich repeat	673..694	CDD:275380	3/21 (14%)
		PP2Cc	754..985	CDD:214625	53/318 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900