Protein Alignment Gyc88E and gcy-20

DIOPT Version :9

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_507101.1
• Gene: gcy-20 / 184797
• WormBaseID: WBGene00001545
• Length: 1108
• Species: Caenorhabditis elegans
• Alignment Length: 571
• Identity: 169/571 - (29%)
• Similarity: 278/571 - (48%)
• Gaps: 122/571 - (21%)

  Fly    91 RHMRDFLNGLDNLHEY--LKFSYPRMRAPSFICENETKQGLTLHYRSKRRGFVYYTMGQIREVAR 153
            |.||:|.|  |||:::  |....|::.:....|...:...:......:...|..:::  ||:::.
 Worm   588 RQMRNFDN--DNLNKFIGLCLDGPQLLSLWRFCSRGSLSDVISKSSMQMDSFFMFSL--IRDISN 648

  Fly   154 --YFYHK---EMHIELVREEILFD---TVHVT-FQL----TFDN---RAFTLASLAMTREE--KH 200
              ||.|.   :.|.:|.....|.|   .:.:: |.|    ||:|   .....||....|.|  :.
 Worm   649 GLYFIHSSFLKCHGQLTSRCCLIDDRWQIKISGFGLKSVRTFENPKKEDLLWASPEYLRNEDQER 713

  Fly   201 LPISAHVLFEIFPFCMVFGADMVVRSIGNSLM-------VILPELLGKKITAWFDLVRPLIAFKF 258
            ||..     :|:.|.::. |:::.||....|.       ||:.::  ||  ...:..||.:....
 Worm   714 LPEG-----DIYSFGIIC-AEILTRSSAFDLENRKEKPDVIIYQV--KK--GGHNPTRPSLDTGE 768

  Fly   259 QTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSEPEKSLRLKGQMVYMENWRMIMFLGTPV 323
            ..::|..  :..||. |..|||             .||.....:::..:..|::.|.     |.:
 Worm   769 TVVINPA--LLHLVR-DCWTER-------------PSERPSIEQVRSHLNGMKDGRK-----TNL 812

  Fly   324 MPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRT 388
            |..:.:::.|  |.:.|                          |::.|.:.:|    |.||.:::
 Worm   813 MDHVFNMLET--YASTL--------------------------EEEVSDRTKE----LTEEKKKS 845

  Fly   389 DELLYQMIPKQVADRLRRGE--NPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYS 451
            |.|||:|:|:.|||:|:.|:  .|    |.|:.|:|.|||:|.||.:..:.||::||::||.:|:
 Worm   846 DVLLYRMLPRMVADKLKLGQTVEP----ETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYT 906

  Fly   452 IFDKLTERNSVYKVETIGDAYMVVAGAPDKDAN-HAERVCDMALDMVDAITDLKDPSTGQHL--- 512
            |||.:.|:|.|||||||||.|:.|:|.|.::.| |...:..|:|..:.::...:    .|||
 Worm   907 IFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGNDHIRHIARMSLGFLSSLEFFR----VQHLPAE 967

  Fly   513 --RIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHI-SESTKVL---IGPNY 571
              .:|:|::.|:||||:|||.|||||||||.|||||||||.....::|: :|:.::|   :| .:
 Worm   968 RINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASRMESNGKPGQIHVTAEANRMLTQVVG-GF 1031

  Fly   572 KIIERGEIDVKGKGTMGTYWLEERENRLPLQLTAALQV-------HPLSPV 615
            :...|||:.:||||.|.|:||...|:.......||.:|       ..:||:
 Worm  1032 RTESRGEVIIKGKGVMETFWLLGEESGYTAPSKAAPKVIQHRQSIRSISPI 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	18/79 (23%)
		HNOBA	201..404	CDD:311573	45/209 (22%)
		CYCc	383..571	CDD:214485	88/199 (44%)
		Herpes_ICP4_C	794..>955	CDD:332854
gcy-20	NP_507101.1	PBP1_NPR_GC_like	22..439	CDD:107347
		ANF_receptor	44..418	CDD:279440
		PKc_like	536..801	CDD:304357	53/242 (22%)
		STYKc	562..801	CDD:214568	53/242 (22%)
		HNOBA	<818..861	CDD:285003	18/74 (24%)
		CYCc	840..1032	CDD:214485	88/200 (44%)
		Guanylate_cyc	867..1054	CDD:278633	86/195 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810