Protein Alignment Gyc88E and gcy-11

DIOPT Version :10

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_001359843.1
• Gene: gcy-11 / 181745
• WormBaseID: WBGene00001537
• Length: 1168
• Species: Caenorhabditis elegans
• Alignment Length: 648
• Identity: 175/648 - (27%)
• Similarity: 262/648 - (40%)
• Gaps: 226/648 - (34%)

  Fly    20 EKWEDIRRQAGIDSPS---FSVHQVYPENLLQKLAKKAQQVLGVSERDFMDQMGVYFVGFVGQYG 81
            |..|::.|..|:.:.|   |::|...|...|..|.:.....|        |:|  :.|.||
 Worm   671 ETHENLNRFFGLINESDLIFTIHSYGPRKSLMDLLRNDDLRL--------DRM--FKVSFV---- 721

  Fly    82 YDRVLSVLGRHMRDFLNGLDNLHEYLKFSY-PRMRAPSFICENETKQGLTLHYRSKRRGFVYYTM 145
                        .|.:.||..|||..|..| ..:::.:.|.:        .::|.|...   |.|
 Worm   722 ------------EDVVKGLQFLHEGSKIGYHGNLKSSNCIVD--------AYWRIKLSN---YGM 763

  Fly   146 GQIR----------------EVARYF--YHKEMHIELVREEI--------------------LFD 172
            .|||                |:.|.:  .|....:||.:.:|                    |.|
 Worm   764 EQIRVEEPESKPDDLLWFAPEIIRRYAVKHDLSKLELAKADIYSLAIVLYEIYGRQGPFGDDLLD 828

  Fly   173 TVHVTFQLTFDNRAFTLASLAMTREEKHLPISA-HVLFEIFPFCMVFGADMVVRSIGNSLMVILP 236
            :..:..||.|.:..      |:||.:.||...| :.|..:...|.|  .|...|          |
 Worm   829 SDEIIEQLKFPDGG------ALTRPDIHLITKAPYPLASVVEKCWV--EDPASR----------P 875

  Fly   237 ELLGKKITAWFDLVRPL-------IAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDG 294
            .:  ||:.   :|::||       ||.....:|:|..|..|    |.:.||
 Worm   876 SI--KKVR---ELLKPLSKGLKGNIADNIMNLLDRYRNNLE----DVIKER-------------- 917

  Fly   295 SEPEKSLRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVE 359
                                                                       |:|
 Worm   918 -----------------------------------------------------------TEQ--- 920

  Fly   360 LKLALDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILF 424
                                 |::|.:|.:.||.|::||.||:.|:.|: |:| .|.:|||||.|
 Worm   921 ---------------------LEDERKRNESLLLQLLPKSVANSLKNGQ-PVD-AEFYDSVSIYF 962

  Fly   425 SDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDAN-HAER 488
            ||||.||.:.|:.||::||:|||.:|:.||.:.::...|||||||||||.|:|.|:.::. ||..
 Worm   963 SDIVGFTALSSKSTPLQVVNMLNNLYTNFDTIIDKFDCYKVETIGDAYMFVSGLPEVNSYLHAGE 1027

  Fly   489 VCDMALDMVDAI-TDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTS 552
            |...:|:::|:| |........:.||:|:|.|:|.||.|:||::|||||||||||..|:.|||:.
 Worm  1028 VASASLELLDSIKTFTVSHCPDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSG 1092

  Fly   553 IAMKVHISESTKVLI---GPNYKIIERGEIDVKGKGTMGTYWLEE--RENRLPLQLTAALQVH 610
            ..|::.||.....||   | .|...:|.:|.:|.|..:.|||:.:  ::.||     |.|..|
 Worm  1093 EPMRIQISSDAYELILKCG-GYVTEQREKIVLKNKLEVMTYWMNDYSKDARL-----ARLVAH 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..163	CDD:462233	35/164 (21%)
		HNOBA	201..404	CDD:462234	34/210 (16%)
		CYCc	383..571	CDD:214485	90/192 (47%)
		PHA03307	794..>955	CDD:223039
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:471960
		Protein Kinases, catalytic domain	640..890	CDD:473864	60/278 (22%)
		CYCc	923..1116	CDD:214485	91/195 (47%)