Protein Alignment Gyc88E and gcy-32

DIOPT Version :9

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_506452.5
• Gene: gcy-32 / 179887
• WormBaseID: WBGene00001552
• Length: 684
• Species: Caenorhabditis elegans
• Alignment Length: 635
• Identity: 185/635 - (29%)
• Similarity: 327/635 - (51%)
• Gaps: 51/635 - (8%)

  Fly     1 MYGLLLENLSEYIKSVYGEEKWEDIRRQAGIDSPSFSV-HQVYPENLLQKLAKKAQQVLGVSERD 64
            |:|.:.|::.:.:...|||:.|..:..::|.:|...:: :..|.:.....|......||.|::..
 Worm     1 MFGFIHESIRQLVIRNYGEDTWTQVLERSGFESGKENIMNHYYSDTDTYVLVDSVSLVLKVTKDQ 65

  Fly    65 FMDQMGVYFVGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSY--PRMRAPSFICENETKQ 127
            ..:..|.:.:.:..:.|:|.::..:..:::.||:.||:||.::....  ..:|.|||.|| ||..
 Worm    66 VWEMYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCE-ETPD 129

  Fly   128 G-LTLHYRSKRRGFVYYTMGQIREVARYFY------------HKEMHI---ELVREEILFDTVHV 176
            | |.|||.:.|.|..:...|.::|||:..:            .:.:|:   |.|.|.::| .::.
 Worm   130 GTLLLHYFTGRPGLYHIVKGVVKEVAKRVFDLDITLVVQGRTQRSVHMNNGERVEEHVVF-LINN 193

  Fly   177 TFQLTFDNRAFTLASLAMTRE------EKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVIL 235
            ..:...|:....::.|..|..      :..|.||.....:..|:..|......:...|:.|...:
 Worm   194 LSEPRRDSEGSEVSLLTSTNANFPTIVDDTLGISLDDFSKALPYHFVIDESCKLVQCGSELHNHI 258

  Fly   236 P-ELL--GKKITAWFDLVRPLIAFKFQTILNRTNNIFEL-VTVDPVTER-FDVQNEDLLQHEDGS 295
            | |||  |..|...|::.||.|...|:.|.|..|.:|.| |...|:.:: .|..:::.|:.|..:
 Worm   259 PNELLQPGTPILRIFEINRPQIPLDFENICNFINAVFVLQVKTSPLKKKHMDAMSQEELKQEMET 323

  Fly   296 EPEKS---------LRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLML 351
            ..|.:         |:|||||:.:.:.:.|::|.:|.:..:..|:..|:.:..:.:||.:|||:|
 Worm   324 LDEDATNELTQGHHLKLKGQMMLLASKKHIIYLCSPYVTSINELMQYGMRLTAMPLHDATRDLIL 388

  Fly   352 AGTQQ--SVELKLALDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTC 414
            ...|:  .||:.|.|   :..:::||...|.|:.|.::||.:|..|:|:::|.:|..||: |:.|
 Worm   389 LNQQRLSDVEVNLQL---EANNEQLETMTRELELERQKTDSILKDMLPRRIAQQLLSGEH-IEAC 449

  Fly   415 EMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAP 479
            |  ...:::|.|:..|.:...:.:|.::|:|||.::...|::.....||||||:.|:||.|:|.|
 Worm   450 E--HEATVMFCDLPAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRGVYKVETVSDSYMAVSGIP 512

  Fly   480 DKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNT 544
            |....|||.:|.:||.|:.....:.||.:.....:|:|:|||.:.||:||...|:|||||:||..
 Worm   513 DYTPEHAENMCHVALGMMWEARSVIDPVSKTPFLLRIGIHSGTITAGVVGTVHPKYCLFGETVTL 577

  Fly   545 ASRMESTSIAMKVHISE--STKVLIGPNYKIIERGEIDVKGKGTMGTYWL 592
            ||:|||..:|.|:..|:  ..|.:....::...||.||||.:|...||:|
 Worm   578 ASQMESLGMAGKIQCSKWAYQKAMETGRFEFSPRGRIDVKQRGLTETYFL 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	42/180 (23%)
		HNOBA	201..404	CDD:311573	62/218 (28%)
		CYCc	383..571	CDD:214485	70/189 (37%)
		Herpes_ICP4_C	794..>955	CDD:332854
gcy-32	NP_506452.5	HNOB	3..167	CDD:285002	41/164 (25%)
		HNOBA	226..440	CDD:285003	61/216 (28%)
		CYCc	419..608	CDD:214485	70/191 (37%)
		Guanylate_cyc	452..627	CDD:278633	66/174 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780