Protein Alignment Gyc88E and gcy-18

DIOPT Version :10

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: NP_502449.2
• Gene: gcy-18 / 178237
• WormBaseID: WBGene00001543
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 583
• Identity: 170/583 - (29%)
• Similarity: 254/583 - (43%)
• Gaps: 183/583 - (31%)

  Fly   101 DNLHEYLKFSYPRMRAPSFICENETKQGLTLHYRSKRRGFVYYTMGQIREV---ARYFYHKEMHI 162
            |||:.:|..::           ||.::.|.|        :.:.:.|.|:::   |.....::.|.
 Worm   610 DNLNPFLGAAF-----------NEKEEMLVL--------WKFCSRGTIQDIIYNANVVLDEKFHG 655

  Fly   163 ELVREEILFDTVHVTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVR-- 225
            ..||:        :|..|.:.:.:               ||..|  ..:.|:|.:...:.:|:
 Worm   656 AFVRD--------ITLGLEYLHAS---------------PIGYH--GSLTPWCCLIDRNWMVKLS 695

  Fly   226 -------------------------------SIGNSLMVILPELLGKKIT--------AW----- 246
                                           |...|::.:.||||..:.|        :|
 Worm   696 DYGIANPLERWEKQGAIEIAAAKDSDDKSQASQATSIIYMAPELLKNRETNKRRGMDQSWVKQSM 760

  Fly   247 ----------FDLVRPLIAFKFQTILNRTNNIFELV--------TVDPVTERFDVQNEDLLQHED 293
                      |.:|...|.|:.....:.| ||.|||        ||.|     ::||:..| |.|
 Worm   761 LRRQAGDIYSFGMVMYEILFRSLPFRDNT-NISELVDYLADGSKTVSP-----EIQNQMGL-HPD 818

  Fly   294 ---------GSEPE-----KSLRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDL--SM 342
                     ...||     :.:||..:||                     |.|.|..::.:  .|
 Worm   819 LNALLRDCWSENPEIRPSIRRVRLNTEMV---------------------LKTKGSLVDQMMKMM 862

  Fly   343 HDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRG 407
            ..::.:|                     .|.:.|...:|:|...|.|:||.|::|..||:.|:.|
 Worm   863 EQYANNL---------------------EKLVAERTGMLEEANIRADQLLTQLLPAYVANELKMG 906

  Fly   408 ENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAY 472
            .:...  :::.|.:|||||||.||.|||..||:|||:|||.:|:.||:...||..||||||||||
 Worm   907 RSVAP--KLYSSATILFSDIVGFTTICSGSTPLEVVNMLNGLYTGFDECITRNKSYKVETIGDAY 969

  Fly   473 MVVAGAPDK-DANHAERVCDMALDMVDAITDLKDPSTGQH-LRIRVGVHSGAVVAGIVGLKMPRY 535
            |||:|.|:: :.||:..:.:.||||...:|..:.|....| :|.|.|.|:|:|.||:|||..|||
 Worm   970 MVVSGIPEENEYNHSRNIANTALDMRQYLTGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRY 1034

  Fly   536 CLFGDTVNTASRMESTSIAMKVHISESTKVLI---GPNYKIIERGEIDVKGKGTMGTYWLEER 595
            ||||||||.:||||||.....:.:||...:.|   .|.:...||||:.||||||..|:|||:|
 Worm  1035 CLFGDTVNVSSRMESTGTPGMIQMSEEAHMHIRAHHPVFTTTERGEVQVKGKGTCRTFWLEDR 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..163	CDD:462233	12/64 (19%)
		HNOBA	201..404	CDD:462234	55/282 (20%)
		CYCc	383..571	CDD:214485	93/192 (48%)
		PHA03307	794..>955	CDD:223039
gcy-18	NP_502449.2	PBP1_NPR_GC-like	64..446	CDD:380575
		Protein Kinases, catalytic domain	549..846	CDD:473864	52/286 (18%)
		CYCc	882..1073	CDD:214485	93/192 (48%)