DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and gcy-12

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_494995.2	Gene:	gcy-12 / 173902	WormBaseID:	WBGene00001538	Length:	1679	Species:	Caenorhabditis elegans

Alignment Length:	1020	Identity:	271/1020 - (26%)
Similarity:	412/1020 - (40%)	Gaps:	270/1020 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PENLLQKLAKKAQQVLGVSERDFMDQMGVYFVGFVGQYGYDRVLSVLGR-HMRDFLNGLDNLHEY 106
            |::|.::..|:.:.:..::..:..:.:|:    .|.||....|.....: .:.|.|.     :|.
Worm   704 PKDLTREAKKELRAMRQLAHPNVNNFLGI----IVCQYSVTVVREYCSKGSLHDILR-----NEN 759

  Fly   107 LKFSYPRMRAPSFICENETKQGLTLHYRSKRRGFVYYTMGQIREVARYFYHKEMHIELVREEILF 171
            ||..:  |...||:.:             ..:|.||....:::          ||..|.....|
Worm   760 LKLDH--MYVASFVDD-------------LVKGMVYIHDSELK----------MHGNLKSTNCL- 798

  Fly   172 DTVHVTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIF----PFCMVFGADMVVRSIGNSLM 232
                :|.:.|.....|.|..|    .|..:..|::.::|.|    |..|         :|..||.
Worm   799 ----ITSRWTLQIADFGLREL----REGIMYDSSYNIWENFLWTAPEAM---------TINGSLA 846

  Fly   233 VILPELLGKKITAW-FDLVRPLIAFKFQTILNRTN--NIFELVTVDPVTERFDVQNEDLLQHEDG 294
            :..|..  .|..|: |.::       |..|..|..  .|:        .:|.|| |.:....:|.
Worm   847 ISNPPT--PKADAYSFGII-------FHEIFTREGPYKIY--------VQRGDV-NGEAAPKKDS 893

  Fly   295 SE----PEKSLRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLA--- 352
            .|    .||::|    .||.:.:         ..||          .:||.:.::.:::|.|
Worm   894 VECRALVEKTVR----RVYSDPY---------FRPD----------TSDLEVQNYVKEVMAACWH 935

  Fly   353 -GTQQSVELK-----------------------LALDQEQQKSKKL--EESMRLLDEEMRRTDEL 391
             ...|..|.|                       |.:::.|.:.:.|  |.::.|.||: ||:..|
Worm   936 HDPYQRPEFKTIKNKLKPLFHQIYKQNIMDHMVLMMEKYQTQLEDLVDERTIELKDEQ-RRSQHL 999

  Fly   392 LYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKL 456
            |.:|:|..||::|..|::.|.  |.|..|:|.|||||.||.|....||||||:.||.:|::||.:
Worm  1000 LQRMLPSSVAEQLLAGQDVIP--EAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSI 1062

  Fly   457 TERNSVYKVETIGDAYMVVAGAPDKDA--NHAERVCDMALDMVDAITDLKDPSTG-QHLRIRVGV 518
            ..|..||||||||||||||:|.|....  .|||::..||:.::.|:.....|... :.|.||:|:
Worm  1063 IRRYDVYKVETIGDAYMVVSGVPQYKTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMIRIGM 1127

  Fly   519 HSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST-KVL--IGPNYKIIERGEID 580
            |:|..|||:||..||||.||||||||||||||...|:::|.|.|| |||  |...:.:.|||.:.
Worm  1128 HTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLA 1192

  Fly   581 VKGKGTMGTYWLEERENRLPLQLTAALQVHPLSP-VPPTPTPKTKAIMPPVSKPLTPMMPVSVSL 644
            :||||.|.||||   ..|...:.|..::...:.| :.|.|..|.:.....|::      ..|:||
Worm  1193 IKGKGQMTTYWL---NGRAGYEFTETIEDKMVVPDIFPRPNLKNRGSSWGVNR------ESSLSL 1248

  Fly   645 A------------ASMPTSNVPAVDVMASSSSISGLALTAAAAAHM-----------SLHHQAVV 686
            |            |:|..:|   .||:..:..::....|:...::.           ||.:|:.
Worm  1249 ATEKSSQIMKRQSAAMNRNN---QDVIYYNQPLNSGGFTSRGTSNREMPKLYEEDRESLLNQSA- 1309

  Fly   687 AEALTGASVEVALPSVASGATGAAAG---GGAPSDDRNSRIYSPVTF--KDVARRSVANSPVRSC 746
              :|.|:.......|.||...|.:|.   ....|:..:||...|.||  ..:|.|.      ||.
Worm  1310 --SLLGSRTSGRKKSTASKYNGFSASRMFSSTISNASSSRPSRPSTFDHDTLALRK------RST 1366

  Fly   747 AQPDQERRRESRSNSTGHVFMRTPSEIFGSLILDTEEFLEDLQISRSSLANNNNNQSPCGFSPTP 811
            :.||.|:                       |.|   ||:|...::.:|:....||.|    |..|
Worm  1367 SLPDGEK-----------------------LNL---EFIETTNLANNSVPAIPNNIS----SLEP 1401

  Fly   812 PFR-------IGSAPPKPRPSNPDKFTPEELAAMDQLTPP--------STAPARE-TASCSSA-- 858
            .||       ..|....|..|....:       .|..|.|        :..|.|: :.||..|
Worm  1402 VFRKASIIDGYSSQSESPSQSQYPSY-------RDLTTGPHQRKRGIATVFPVRKRSLSCGDAVP 1459

  Fly   859 -SLDRDKATKLKKITFSNSSSLDATTPT-ALAAVVCPMRTKSPPMAV------APVMHMVQASTS 915
             .::.:.|:.......|..||..|..|| .|||     |..||...:      ..::......||
Worm  1460 LKINENGASGSITTAVSPRSSCRALDPTMKLAA-----RASSPDEIIFQEDDEDALIDNDSLLTS 1519

  Fly   916 KGDGQRPGSKDSVSSISLHSPPPHRSN--SAPARPHSMSKAARKA 958
            .|:.:   |:|.:.:    .|.|.|.|  |....|..::|..|.|
Worm  1520 NGNSK---SEDVLRT----CPQPRRKNKHSFLRDPSPLAKRFRDA 1557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	21/121 (17%)
		HNOBA	201..404	CDD:311573	51/242 (21%)
		CYCc	383..571	CDD:214485	97/193 (50%)
		Herpes_ICP4_C	794..>955	CDD:332854	44/188 (23%)
gcy-12	NP_494995.2	PBP1_Speract_GC_like	123..545	CDD:107365
		ANF_receptor	140..519	CDD:279440
		PK_GC-A_B	648..957	CDD:270944	65/345 (19%)
		TyrKc	688..951	CDD:197581	65/339 (19%)
		HNOBA	<967..1012	CDD:285003	15/45 (33%)
		CYCc	991..1183	CDD:214485	98/194 (51%)
		Guanylate_cyc	1018..1206	CDD:278633	98/192 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810