DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and Gucy2e

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	442	Identity:	144/442 - (32%)
Similarity:	221/442 - (50%)	Gaps:	93/442 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 EIFPFCMVFGADMVVRSIGNSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTV 274
            ::|...::. .::|.||...:::.:.||.:.:::.:...|.||                  ||::
Mouse   762 DVFSLAIIM-QEVVCRSTPYAMLELTPEEVIQRVRSPPPLCRP------------------LVSM 807

  Fly   275 DPV-TERFDVQNEDLLQHEDGSEPEKSLRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYIN 338
            |.. .|...:..:...:|     ||  ||....:.:                ||...|..|...|
Mouse   808 DQAPMECIQLMTQCWAEH-----PE--LRPSMDLTF----------------DLFKSINKGRKTN 849

  Fly   339 DLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESMR----LLDEEMRRTDELLYQMIPKQ 399
            .:       |.||.             ..:|.|..||:.:|    .|::|.::||.||.||:|..
Mouse   850 II-------DSMLR-------------MLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPS 894

  Fly   400 VADRLRRGEN--PIDTCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSV 462
            ||:.|:.|.:  |    |.|:.|::.|||||.||.|.:...|:|||.:||.:|::||.:...:.|
Mouse   895 VAEALKMGTSVEP----EYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDV 955

  Fly   463 YKVETIGDAYMVVAGAPDKDA-NHAERVCDMALDMVDAITDLKDPSTGQHL-----RIRVGVHSG 521
            ||||||||||||.:|.|.::. .||..:.:|:||::.|:...:    .:|:     |||:|:|||
Mouse   956 YKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFR----MRHMPEVPVRIRIGLHSG 1016

  Fly   522 AVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISEST-KVL--IGPNYKIIERGEIDVKG 583
            ..|||:|||.||||||||||||||||||||.:..::|::.|| ::|  :...:::..||..::||
Mouse  1017 PCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKG 1081

  Fly   584 KGTMGTYWLEER---ENRLP----LQLTAALQVHPLSPVPPTPTPKTKAIMP 628
            ||...||||..|   ...:|    ||..|:.....|..:||....|.:...|
Mouse  1082 KGIEDTYWLVGRLGFNKPIPKPPDLQPGASNHGISLQEIPPERRKKLEKARP 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	42/198 (21%)
		CYCc	383..571	CDD:214485	92/198 (46%)
		Herpes_ICP4_C	794..>955	CDD:332854
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945	21/124 (17%)
		HNOBA	<854..899	CDD:400168	18/57 (32%)
		CYCc	879..1070	CDD:214485	92/198 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810