DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	643	Identity:	193/643 - (30%)
Similarity:	283/643 - (44%)	Gaps:	136/643 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EEKWEDIRRQAGIDSPSFSVHQVYPENLLQKLAKKAQQV-LGVSE---RDFMDQMGVYFVGFVGQ 79
            ::||..|        ||        ||:......:...: |.:.:   ||.:.:        |.|
Mouse   465 QKKWSHI--------PS--------ENIFPLETNETNHISLKIDDDRRRDTIQR--------VRQ 505

  Fly    80 YGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMRAPSFICENETKQGLTLHYRSKRRGFV-YY 143
            ..||:...:|    :|..:...|..|..|....::....:.  |.||...|:...::..|.| |.
Mouse   506 CKYDKKKVIL----KDLKHSDGNFSEKQKIDLNKLLQSDYY--NLTKFYGTVKLDTRIFGVVEYC 564

  Fly   144 TMGQIREVARYFYHKEMHIELVREEILFDTVHV---TFQLTFDNRAFTLASLAMTREEKH-LPIS 204
            ..|.:|||                  |.||:..   || :.::.:...|..:|......| ..|.
Mouse   565 ERGSLREV------------------LNDTISYPDGTF-MDWEFKISVLNDIAKGMSYLHSSKIE 610

  Fly   205 AHVLFEIFPFCMVFGADMVVRSIGNSLMVILPELLGKK--ITAWFDLVRPLIAFK---------F 258
            .|...: ...|:| .:.|||:........|||.   ||  .||...|.:..|:.|         .
Mouse   611 VHGRLK-STNCVV-DSRMVVKITDFGCNSILPP---KKDLWTAPEHLRQATISQKGDVYSFAIIA 670

  Fly   259 QTILNRTNNIFELVTVDPVTERFDVQNE-------DL-LQHEDGSEPEKSLRLKGQMVYMENWRM 315
            |.|:.|....:.|...|...:.|.|:|.       || |:..|..|.|..|.:|      ..|..
Mouse   671 QEIILRKETFYTLSCRDHNEKIFRVENSYGKPFRPDLFLETADEKELEVYLLVK------SCWEE 729

  Fly   316 IMFLGTPVMPDLTSLITT-----GLYINDLSMHDFSRDLMLAGTQQSVELKLALDQEQQKSKKLE 375
                .....||...:.:|     ||:      ||...:..:....:.::|     ..:.....:|
Mouse   730 ----DPEKRPDFKKIESTLAKIFGLF------HDQKNESYMDTLIRRLQL-----YSRNLEHLVE 779

  Fly   376 ESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSDIVTFTEICSRITPM 440
            |..:|...|..|.|.|.:.::|:.|...|:  |..|...|:::.|:|.|||||.||.||...|||
Mouse   780 ERTQLYKAERDRADHLNFMLLPRLVVKSLK--EKGIVEPELYEEVTIYFSDIVGFTTICKYSTPM 842

  Fly   441 EVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDAN-HAERVCDMALDMVDAITDLK 504
            |||.|||.:|..||::.:.:.|||||||||||:|.:|.|.::.| ||..:..||||::..|...:
Mouse   843 EVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFE 907

  Fly   505 -DPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIG 568
             :...|..:.||:|||||...||:||:|||||||||||||||||||||.:.:::|:|.||..::.
Mouse   908 LEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILK 972

  Fly   569 PN-----YKIIERGEIDVKGKGTMGTYWL---EERENRLPLQLTAALQVHPLSPVPPT 618
            ..     |::  |||..:||:||..||||   :::|..|              |.|||
Mouse   973 RTDCQFLYEV--RGETYLKGRGTETTYWLTGMKDQEYNL--------------PSPPT 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	30/149 (20%)
		HNOBA	201..404	CDD:311573	51/226 (23%)
		CYCc	383..571	CDD:214485	92/194 (47%)
		Herpes_ICP4_C	794..>955	CDD:332854
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141
		PKc_like	480..749	CDD:304357	68/316 (22%)
		STYKc	502..744	CDD:214568	64/289 (22%)
		CYCc	787..978	CDD:214485	92/192 (48%)
		Guanylate_cyc	814..1001	CDD:278633	95/188 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810