DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gyc88E and LRRK2

DIOPT Version :9

Sequence 1:NP_001036711.1 Gene:Gyc88E / 41825 FlyBaseID:FBgn0038295 Length:1097 Species:Drosophila melanogaster
Sequence 2:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens


Alignment Length:1067 Identity:190/1067 - (17%)
Similarity:347/1067 - (32%) Gaps:384/1067 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 QGLTLHYRSKRRGFVYYTMGQIREVARY------FYHKEMHIEL---------VREEILFDTVHV 176
            :.||.|.::|          .::|.|.:      .|...:|.::         .||.:|...:|.
Human   355 KALTWHRKNK----------HVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHS 409

  Fly   177 TFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIGNSLMVILPELLGK 241
            :.:..|...|..|::|          :..:|.|.           .::.|.|..|.|:  ||:.|
Human   410 SSKEVFQASANALSTL----------LEQNVNFR-----------KILLSKGIHLNVL--ELMQK 451

  Fly   242 KITAWFDLVRPLIAFKFQTILNRTNNIFE--------LVTVDP----VTERFD----VQNEDL-- 288
            .|.:      |.:|   ::.....|::||        :..|.|    |.:|.:    ||.|.|  
Human   452 HIHS------PEVA---ESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALRA 507

  Fly   289 LQH-----------EDGSEPEKSLRLKGQMVYMENWRMIM-----FLGTPVMPDLTSLITTGLYI 337
            :.|           ||.....|...:|.|....:..::::     |:|.|      .:...||.:
Human   508 ILHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNP------GIQKCGLKV 566

  Fly   338 NDLSMH--DFSRDLMLAGTQQSVELKLALDQEQQKSKKLEESM--RLLDEE--MRRTDELLYQMI 396
            ....:|  |....|.|.|...||...|.:..:.|:.:.|..|:  .|:.::  ...|..||.:::
Human   567 ISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKIL 631

  Fly   397 P------KQVADRLRRGENPIDTCEMFDSVSILFS--------DIVTFTEICSRITPMEVVSMLN 447
            .      |.||:...:|   ..|......:|..||        |:|.|.::.|.|...:....||
Human   632 VSSLYRFKDVAEIQTKG---FQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLN 693

  Fly   448 AMYSIFDKLT--------------ERNSVYKVETIGDAYMVVAGAPDKDANHAE-------RVC- 490
            .....|.|:.              ::|:...||.     :::.||   |||.|:       :|| 
Human   694 LCCKCFAKVAMDDYLKNVMLERACDQNNSIMVEC-----LLLLGA---DANQAKEGSSLICQVCE 750

  Fly   491 -DMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPR--------------YC---- 536
             :.:..:|:.:  |...|..|.:|..:.:..|...:.|:.|.:.|              :|    
Human   751 KESSPKLVELL--LNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKV 813

  Fly   537 -------LFGDTVNTASRMESTSIA-----------MKVHISESTKVLIGPNY------------ 571
                   ||.|  .|::..:.|:||           ||..:.|.|......|:            
Human   814 EPSWLGPLFPD--KTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWT 876

  Fly   572 --------KIIERGEIDVKGKGTMGTYWLEERENRLPL----------QLTAALQVHPLSPVPPT 618
                    .:..:.: |:..:|:.|::.::::.|.:.:          :.:..||.|..|     
Human   877 FIPDSSMDSVFAQSD-DLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNS----- 935

  Fly   619 PTPKTKAIMPPV------SKPLTPMMPVSVSLAASMPTSNVPAVDVMASSSSISGLALTAAAAAH 677
                    :.|:      .|....::....||.:|...|:      |..|.|||.||........
Human   936 --------LGPIFDHEDLLKRKRKILSSDDSLRSSKLQSH------MRHSDSISSLASEREYITS 986

  Fly   678 MSLH-HQAVVAEALT-GASVEVALPSVASGATGAAAGGGAPSDDRNSRIYSPVTFKDVARRSVAN 740
            :.|. ::....:||: ...:.|.|..:..                          .::.:.::.:
Human   987 LDLSANELRDIDALSQKCCISVHLEHLEK--------------------------LELHQNALTS 1025

  Fly   741 SPVRSCAQPDQERRRESRSNSTGHVFMRTPSEIFGSLILDTEEFLEDLQISRSSLANNNNNQSPC 805
            .|.:.|.........:..||.    |...||.:                :..|.:||.:.:::..
Human  1026 FPQQLCETLKSLTHLDLHSNK----FTSFPSYL----------------LKMSCIANLDVSRNDI 1070

  Fly   806 GFSPT--PPFRIGSAPPKPRPSNPDKFTPEELAAMDQLTPPSTAPARETASCSSASLDRDKATKL 868
            |.|..  |..:..:........|...|.||.|.                          |...||
Human  1071 GPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLT--------------------------DVVEKL 1109

  Fly   869 KKITFSNSSSLDATTPTALAAVVCPMRTKSPPMAVAPVMHMVQASTSKGDGQRPGSKDSVSSISL 933
            :::....:.         ::.:..|:|.|.     ..::::              ||:.:||:| 
Human  1110 EQLILEGNK---------ISGICSPLRLKE-----LKILNL--------------SKNHISSLS- 1145

  Fly   934 HSPPPHRSNSAPARPHSMSKAARKAFLAA-------------KQTK------------AMEKLDK 973
                   .|...|.|...|.:||..||||             .|.|            .:..||.
Human  1146 -------ENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDM 1203

  Fly   974 MIEEVQEVESQSVAKAANMRLALYGHD 1000
            ...::|.:...:..|:.|:|..|:.|:
Human  1204 SSNDIQYLPGPAHWKSLNLRELLFSHN 1230

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc88ENP_001036711.1 HNOB 2..164 CDD:311572 8/42 (19%)
HNOBA 201..404 CDD:311573 52/248 (21%)
CYCc 383..571 CDD:214485 52/262 (20%)
Herpes_ICP4_C 794..>955 CDD:332854 25/162 (15%)
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 1..969 129/696 (19%)
LRR 1 983..1004 3/20 (15%)
leucine-rich repeat 985..1012 CDD:275380 5/26 (19%)
LRR 1012..>1286 CDD:227223 49/327 (15%)
LRR 2 1012..1033 2/46 (4%)
leucine-rich repeat 1013..1036 CDD:275380 2/48 (4%)
LRR 3 1036..1057 5/40 (13%)
leucine-rich repeat 1037..1084 CDD:275380 11/66 (17%)
LRR 4 1059..1080 5/20 (25%)
LRR 5 1084..1105 5/46 (11%)
leucine-rich repeat 1085..1108 CDD:275380 6/48 (13%)
LRR 6 1108..1129 4/29 (14%)
leucine-rich repeat 1109..1130 CDD:275380 3/29 (10%)
LRR 7 1130..1150 6/46 (13%)
leucine-rich repeat 1131..1174 CDD:275380 15/64 (23%)
LRR 8 1174..1196 2/21 (10%)
leucine-rich repeat 1175..1197 CDD:275380 2/21 (10%)
LRR 9 1197..1218 3/20 (15%)
leucine-rich repeat 1198..1221 CDD:275380 4/22 (18%)
LRR 10 1221..1241 4/10 (40%)
leucine-rich repeat 1222..1246 CDD:275380 3/9 (33%)
LRR 11 1246..1267
leucine-rich repeat 1247..1269 CDD:275380
LRR 12 1269..1291
RocCOR 1334..1507 CDD:206741
COR 1527..1740 CDD:318343
STKc_LRRK2 1884..2135 CDD:270970
WD 1 2139..2183
WD 2 2188..2228
WD 3 2233..2276
WD 4 2281..2327
WD 5 2333..2377
WD 6 2402..2438
WD 7 2443..2497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.