DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc88E and Adcy8

DIOPT Version :9

Sequence 1:NP_001036711.1 Gene:Gyc88E / 41825 FlyBaseID:FBgn0038295 Length:1097 Species:Drosophila melanogaster
Sequence 2:NP_033753.2 Gene:Adcy8 / 11514 MGIID:1341110 Length:1249 Species:Mus musculus


Alignment Length:562 Identity:129/562 - (22%)
Similarity:233/562 - (41%) Gaps:154/562 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 VREEILFDTVHVTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIGN 229
            :|:|:....:...|          :..|.:|..:..||.|     .:.|..:.|...:::.|   
Mouse   705 MRDEVFKSNLVCAF----------IVLLFITAIQSLLPSS-----RLMPMTIQFSILIMLHS--- 751

  Fly   230 SLMVI--------LPELLGKKITAWFD---LVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDV 283
            :|::|        ||.:| :|...|.:   |.|.:|.|. ..::|....:..::..|        
Mouse   752 ALVLITTAEDYKCLPLIL-RKTCCWINETYLARNVIIFA-SILINFLGAVLNILWCD-------- 806

  Fly   284 QNEDLLQHEDGSEPEKSLRLKGQMVYMENW---RMIMFLGTPVMPD------------------- 326
                    .|.|.|.|:|......|:.:..   ...:|.|...|..                   
Mouse   807 --------FDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIM 863

  Fly   327 ------LTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELKLAL--------DQEQQKSKKLE-- 375
                  ||..|..||:::..:::....|.:  ||:::..|.:|:        .|:.:.:.:|:  
Mouse   864 IAIYALLTETIYAGLFLSYDNLNHSGEDFL--GTKEASLLLMAMFLLAVFYHGQQLEYTARLDFL 926

  Fly   376 ------ESMRLLDEEMRRTDELLYQMIPKQVA------DRLRRGENPIDTCEMFDSVSILFSDIV 428
                  |.:..:.|.....:.:|..::|..||      ||    :|.....:.:|:|.::|:.|.
Mouse   927 WRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDR----DNEELYSQSYDAVGVMFASIP 987

  Fly   429 TFTEICSRITPM-----EVVSMLNAMYSIFDKLTERN---SVYKVETIGDAYMVVAG-APDKDA- 483
            .|.:..|: |.|     |.:.:||.:.:.||:|...:   .:.|::|||..||.|:| :|:|.. 
Mouse   988 GFADFYSQ-TEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQC 1051

  Fly   484 ----NHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNT 544
                .|...:.|.:|.:.::|.::...|. .:..:|:|:..|:||||::|.|.|:|.::|.|||.
Mouse  1052 EDKWGHLCALADFSLALTESIQEINKHSF-NNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNL 1115

  Fly   545 ASRMESTSIAMKVHISESTKVLI-GPNYKIIERGEIDVKG----KGTMGTYWLEERENRLPLQLT 604
            ||||:||.::.::.:.|.|.::: ...:....||||.|||    :|.:.||:|            
Mouse  1116 ASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL------------ 1168

  Fly   605 AALQVHPLSPVPPTPTPKTKAIMPPVSKPLTPMMPVSVSLAA 646
                   |..|.|.|     .|:||      ..:|...||||
Mouse  1169 -------LGRVQPNP-----FILPP------RRLPGQYSLAA 1192

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc88ENP_001036711.1 HNOB 2..164 CDD:311572
HNOBA 201..404 CDD:311573 47/263 (18%)
CYCc 383..571 CDD:214485 60/208 (29%)
Herpes_ICP4_C 794..>955 CDD:332854
Adcy8NP_033753.2 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..180
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..107
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 14..33
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..118
AC_N <159..398 CDD:292831
CYCc 364..562 CDD:214485
Guanylate_cyc 403..587 CDD:278633
DUF1053 615..709 CDD:283888 1/3 (33%)
CYCc 942..1146 CDD:214485 59/209 (28%)
Guanylate_cyc 971..1170 CDD:278633 63/219 (29%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1107..1249 35/116 (30%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1198..1213
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1221..1249
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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