DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and ADCY9

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	XP_005255136.1	Gene:	ADCY9 / 115	HGNCID:	240	Length:	1372	Species:	Homo sapiens

Alignment Length:	736	Identity:	168/736 - (22%)
Similarity:	277/736 - (37%)	Gaps:	191/736 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 HVLFEIFPFCMVFGADMVVRSIGNSLMVILPEL----------------LGKKITAWFDLVRPLI 254
            :.||.|...|:::.....|......::::.|.|                |..:..||..|...|:
Human   118 YALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALTLL 182

  Fly   255 AFKFQTILNRTNNIFELVTVDPVTERFDVQN-------EDLLQHEDGSEPEKSLRLKGQMVYMEN 312
            .|.......     |:::|  ||:.|.|..|       .|....:.||   .|:.::
Human   183 VFALTLAAQ-----FQVLT--PVSGRGDSSNLTATARPTDTCLSQVGS---FSMCIE-------- 229

  Fly   313 WRMIMFLGTPVM--PDLTSLI----------TTGLYIND-----------LSMHDFSRDLMLAGT 354
               ::||...||  |...||.          |.|.:..|           |.....||.| |.|.
Human   230 ---VLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGL-LHGC 290

  Fly   355 QQSVELKL-ALDQEQQKSKKLEESMRL-----LDEEMRRTDELLYQMIPKQVADRLRR-----GE 408
            ..::.:.| .:.|.:.:|..|:....:     |:.|....:.:::.::|:.:||.|.:     .|
Human   291 IHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESE 355

  Fly   409 NPID--------------------------TCEMFDSVSILFSDIVTFTEICSRITPMEVVSMLN 447
            |.:.                          ..:..:.|||||:|||.||::.:..:...:|.:||
Human   356 NSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLN 420

  Fly   448 AMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPSTGQHL 512
            .::..||:|.|.....|:.|:||.|..|||.|:..|:||....:|.|.|:.||........ :.:
Human   421 DLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEKK-EMV 484

  Fly   513 RIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGPNY-----K 572
            .:|||||:|.|:.||:|::..::.::.:.||.|:.||...:|.||||||:|...:...|     |
Human   485 NMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGK 549

  Fly   573 IIER-GEIDVKG--KGTMGTYWL---EERENRLPL--QLTAALQVHPLSPVPPTPTPKTKAIMPP 629
            :||| |:..|..  || :.||.:   ..:|:|...  .|.:..:|...|.|...|..:..|....
Human   550 VIERLGQSVVADQLKG-LKTYLISGQRAKESRCSCAEALLSGFEVIDGSQVSSGPRGQGTASSGN 613

  Fly   630 VSKPLTPMMPVSVSLAASMPT----SNVPAVDVMASSSSISGLALTAAAAAHMSLHHQA--VVAE 688
            ||           .||.::.|    ...|:..:..:..|.:|....|........|..:  |.:.
Human   614 VS-----------DLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGAPQNGCQDEHKNSTKVTSS 667

  Fly   689 ALTGASVE-VALPSVASGATGAAAGGGAPSDDRNSRIYS-------------------------- 726
            .|...||. :|.|..|||........|..|..:..::.:
Human   668 WLLFLSVPLLAHPPKASGGPNPKTQNGLLSPPQEEKLTNSQTSLCEILQEKGRWAGVSLDQSALL 732

  Fly   727 PVTFKDVARRSVAN-----------------SPVR--SCAQPDQERRRESRSNSTGHVFMRTPSE 772
            |:.||::..::.|:                 .|:.  |....|||..|..|::....|...:|.:
Human   733 PLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVK 797

  Fly   773 IFGS--------LILDTEEFL 785
            .|.|        :.|.|..||
Human   798 TFASPTFSSLLDVFLSTTVFL 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	49/249 (20%)
		CYCc	383..571	CDD:214485	64/218 (29%)
		Herpes_ICP4_C	794..>955	CDD:332854
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113	41/204 (20%)
		CYCc	326..544	CDD:214485	64/218 (29%)
		Guanylate_cyc	385..573	CDD:278633	68/189 (36%)
		CYCc	1043..1243	CDD:214485
		Guanylate_cyc	1069..1260	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810