Protein Alignment Gyc88E and ADCY3

DIOPT Version :9

• Sequence 1: NP_001036711.1
• Gene: Gyc88E / 41825
• FlyBaseID: FBgn0038295
• Length: 1097
• Species: Drosophila melanogaster
• Sequence 2: XP_011530791.1
• Gene: ADCY3 / 109
• HGNCID: 234
• Length: 1186
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 125/536 - (23%)
• Similarity: 209/536 - (38%)
• Gaps: 168/536 - (31%)

  Fly   168 EILFD----TVHVTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVRSIG 228
            |||.|    |.:|||.:                        ..:|..|...|
Human   691 EILIDPWLMTNYVTFMV------------------------GEILLLILTIC------------- 718

  Fly   229 NSLMVILPELLGKKITAWFDLVRPLIAFKFQTILNRT---NNIFELVTVDPVTERFDVQNEDLLQ 290
             ||..|.|....||:.|            |.|.::||   .|.:.::.:..:.....|.....||
Human   719 -SLAAIFPRAFPKKLVA------------FSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQ 770

  Fly   291 HEDG-SEPEKSLRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGT 354
            :..| |.....:..:|..  :||.:...::.      :.|||.|.:.:....|...:..|::||.
Human   771 YYTGPSNATAGMETEGSC--LENPKYYNYVA------VLSLIATIMLVQVSHMVKLTLMLLVAGA 827

  Fly   355 QQSVEL---------------------KLALDQEQ------------------------------ 368
            ..::.|                     .:||:|.|
Human   828 VATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDSRLPLVPSKYSMTVMVFLMM 892

  Fly   369 ----QKSKKLEESMRLL--------DE-----EMRRTDE-LLYQMIPKQVADRL----RRGENPI 411
                ..|:.:|:..|.|        |:     ||||.:| |:..|:|:.||...    :|.|...
Human   893 LSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELY 957

  Fly   412 DTCEMFDSVSILFSDIVTF----TEICSRITPMEVVSMLNAMYSIFDKLTER---NSVYKVETIG 469
            .  :.:|.:.::|:.:..|    ||.......:|.:..||.:.|.||.|.:.   ..:.|::|||
Human   958 S--QTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIG 1020

  Fly   470 DAYMVVAG-APDKDAN-----------------HAERVCDMALDMVDAITDLKDPSTGQHLRIRV 516
            ..||..:| .||.:.|                 |...:.|.||.|.|.:|::.:.|....: :|:
Human  1021 STYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFM-LRI 1084

  Fly   517 GVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGP-NYKIIERGEID 580
            |::.|.|:||::|.:.|.|.::|:|||.|||||||.:...:.:.|.|:|::.. .::.:.||.|.
Human  1085 GMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIF 1149

  Fly   581 VKGKGTMGTYWLEERE 596
            |||||.:.|::|:.|:
Human  1150 VKGKGELLTFFLKGRD 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	51/275 (19%)
		CYCc	383..571	CDD:214485	65/223 (29%)
		Herpes_ICP4_C	794..>955	CDD:332854
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831
		CYCc	273..490	CDD:214485
		Guanylate_cyc	310..516	CDD:278633
		CYCc	925..1143	CDD:214485	65/220 (30%)
		Guanylate_cyc	956..1163	CDD:278633	63/209 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810