DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc88E and ADCY2

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens

Alignment Length:	276	Identity:	88/276 - (31%)
Similarity:	148/276 - (53%)	Gaps:	25/276 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 LAGTQQSVELKLALDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQV-----ADRLRRGENP 410
            |||......::|||.|..|.:....:|...|:.|.|:.:.||..::|..:     |:.::|.:.|
Human   203 LAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGP 267

  Fly   411 ----IDTCEMF--------DSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVY 463
                ::....|        .:||||::|||.||.:.|..:|.|:|.|||.::..||::.:.|...
Human   268 KAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECM 332

  Fly   464 KVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIV 528
            :::.:||.|..|:|.|....|||:....|.|||.:||..::| :||..:.:|||||||.|:.|::
Human   333 RIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRD-ATGVDINMRVGVHSGNVLCGVI 396

  Fly   529 GLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGPNYKIIERGEIDVKG----KGTMGT 589
            ||:..:|.::...|..|:.||:..:..:||||..|...:...|| :|.|:.|::.    :..:.|
Human   397 GLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYK-VEEGDGDIRDPYLKQHLVKT 460

  Fly   590 YWL--EERENRLPLQL 603
            |::  .:.|.|.|..|
Human   461 YFVINPKGERRSPQHL 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	16/57 (28%)
		CYCc	383..571	CDD:214485	67/204 (33%)
		Herpes_ICP4_C	794..>955	CDD:332854
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831	16/56 (29%)
		CYCc	236..439	CDD:214485	67/203 (33%)
		Guanylate_cyc	281..465	CDD:278633	65/185 (35%)
		DUF1053	495..599	CDD:283888
		CYCc	848..1056	CDD:214485
		Guanylate_cyc	878..1077	CDD:278633
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810