DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc88E and ADCY1

DIOPT Version :9

Sequence 1:NP_001036711.1 Gene:Gyc88E / 41825 FlyBaseID:FBgn0038295 Length:1097 Species:Drosophila melanogaster
Sequence 2:NP_066939.1 Gene:ADCY1 / 107 HGNCID:232 Length:1119 Species:Homo sapiens


Alignment Length:616 Identity:147/616 - (23%)
Similarity:252/616 - (40%) Gaps:145/616 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 CENETKQGLTLHYRSKRR-------GFVYYTMGQ--IREVARYFYHKEMHIELVREEILFDTVHV 176
            ||::.|:........|.|       ..||.|.|.  .|.::|....::..:|:.           
Human   530 CEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMA----------- 583

  Fly   177 TFQLTFDNRAFTLASLAMTREEKHLPI------SAHVLFEIFP------FCMVFGADMVVRSIGN 229
                  |...|||....:.||:|:..:      ||.||..|..      :.::|...:||     
Human   584 ------DLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVV----- 637

  Fly   230 SLMVILPELLGKKITAWFDLVR-----PLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLL 289
            .|:::...........:..:.|     ..:..:.:|:|    .||.:|.:..|.:...|   ..|
Human   638 LLLLVFCICFLVACVLYLHITRVQCFPGCLTIQIRTVL----CIFIVVLIYSVAQGCVV---GCL 695

  Fly   290 QHEDGSEPEKSLRL---KGQMVYM--------ENWRMIMFLGT------------PVMPDLTSLI 331
            .....|:|..||.:   .||...:        .:..:...:||            |.|..|:.|.
Human   696 PWAWSSKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLT 760

  Fly   332 TTGLYINDLSMHD--------------------FSRDLMLAGTQQSVELKL----ALDQEQQKSK 372
            |:.:.:.:||.:.                    ||..|.|...|..:.|:|    |...|:::  
Human   761 TSYILVLELSGYTRTGGGAVSGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEER-- 823

  Fly   373 KLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDT---CEMFDSVSILFSDIVTFT--- 431
               |.|..:..:.||   :|:.::|..||..... .||.:.   .:.:..|.::|:.|..|.   
Human   824 ---EDMEKVKLDNRR---ILFNLLPAHVAQHFLM-SNPRNMDLYYQSYSQVGVMFASIPNFNDFY 881

  Fly   432 -EICSRITPMEVVSMLNAMYSIFDKLTERN---SVYKVETIGDAYMVVAG-APDKD-------AN 484
             |:......:|.:.:||.:.:.||:|.|::   .:.|::|||..||...| ||...       ::
Human   882 IELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISS 946

  Fly   485 HAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRME 549
            |...:.|.|::|.|.:.::...|....: :|||::.|.||||::|.:.|:|.::|:|||.||||:
Human   947 HLSTLADFAIEMFDVLDEINYQSYNDFV-LRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMD 1010

  Fly   550 STSIAMKVHISEST-KVLIGPNYKIIERGEIDVKGKGTMGTYWLEERENRLPLQL---------- 603
            ||.:..::.::|.. ::|....|..:.||::.|||||.|.||:||.|.:....|:          
Human  1011 STGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMC 1075

  Fly   604 ---TAALQVHPLSPVPPTPTPKTKAIMPPVS 631
               .|.||.. ..||.|.|....:|.:||.|
Human  1076 PFGRAGLQGR-RPPVCPMPGVSVRAGLPPHS 1105

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc88ENP_001036711.1 HNOB 2..164 CDD:311572 11/51 (22%)
HNOBA 201..404 CDD:311573 50/266 (19%)
CYCc 383..571 CDD:214485 58/206 (28%)
Herpes_ICP4_C 794..>955 CDD:332854
ADCY1NP_066939.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
AC_N <161..292 CDD:292831
CYCc 258..453 CDD:214485
Guanylate_cyc 294..476 CDD:278633
Interaction with calmodulin. /evidence=ECO:0000250 493..520
CYCc 826..1037 CDD:214485 60/215 (28%)
Guanylate_cyc 859..1056 CDD:278633 62/197 (31%)
Interaction with calmodulin. /evidence=ECO:0000250 1024..1047 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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