DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc88E and adcy1

DIOPT Version :9

Sequence 1:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster
Sequence 2:	XP_002933461.1	Gene:	adcy1 / 100492373	XenbaseID:	XB-GENE-950909	Length:	1122	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	130/529 - (24%)
Similarity:	237/529 - (44%)	Gaps:	98/529 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 EILFDTVHVTFQLTFDNRAF--------TLASL------AMTREEKHLPISAHVLFEIFPFCMVF 218
            |.||...::..:.|...:|.        |||.|      ::|..:...|:          .|::|
Frog    44 ESLFQNYNLKLEQTSTLKALAVLIIMTGTLALLELMSGPSLTISKGSHPV----------HCIIF 98

  Fly   219 GADMVVRSIGNSLMVILPELLGKKITAWFDLVRPLI-------AFKFQTILNRTNNIFELVTVDP 276
            .:..:|.::....:..|.:::  |:|..|......:       |:..:..::....:::|:.|..
Frog    99 LSLFIVTNVKYLQVTQLQQIV--KLTLLFGFTFSFLCCPFSLGAYGLEPPVSSEQGLWQLMLVTF 161

  Fly   277 VTERFDVQNEDLLQHEDGSEPEKSLR--LKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYIND 339
            |...       ||       |.::|.  :.|.||.:.:   |:...|.:.|....|..| |.:|.
Frog   162 VAYA-------LL-------PVRTLLAIVFGFMVSVSH---IIVTATSISPKKKRLWRT-LVVNA 208

  Fly   340 LSMHDFSRDLMLAGTQQSVELKLALDQEQQKS-----KKLEESMRLLDEEMRRTDELLYQMIPKQ 399
            :        |.::.....|.:::..::.|:|:     ..:|:.:||.||. .:.:.||..::|:.
Frog   209 I--------LFVSVNLSGVFVRILTERAQRKAFLQARNCIEDRLRLEDEN-EKQERLLMSLLPRN 264

  Fly   400 VA-----DRLRRGENPIDT--CEMFDSVSILFSDIVTFTEICSRITPMEVVSMLNAMYSIFDKLT 457
            ||     |.|:..|.....  .:..|:|||||:|||.||.:.|:.|..|:|.:||.::..||:|.
Frog   265 VAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTSLASQCTAQELVKLLNELFGKFDELA 329

  Fly   458 ERNSVYKVETIGDAYMVVAGAPDKDANHAERVCDMALDMVDAITDLKDPSTGQHLRIRVGVHSGA 522
            ..|...:::.:||.|..|:|......:||....:|.|||:|.||.:.: :|...|.:|||:|:|.
Frog   330 TENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAE-ATEVDLNMRVGLHTGR 393

  Fly   523 VVAGIVGLKMPRYCLFGDTVNTASRMESTSIAMKVHISESTKVLIGPNYKI-----IERGEIDVK 582
            |:.|::||:..:|.::.:.|..|:.||:..:..||||:::|...:..:|::     .||... :|
Frog   394 VLCGVLGLRKWQYDVWSNDVTLANVMEAGGLPGKVHITKNTLECLNGDYEVEPGYGHERNSF-LK 457

  Fly   583 GKGTMGTYWLEERENRLPLQLTAALQVHP---LSPVPPTPTPKTKAIMPPVSKPLTPMMPVSVSL 644
             |..:.|:::.....|         ::.|   ||.:.|....|.|.    |...|..:|......
Frog   458 -KHNIETFFIVPSHRR---------KIFPGLILSDIKPAKRMKFKT----VCYLLVQLMHCRKMF 508

  Fly   645 AASMPTSNV 653
            .|.:|.|||
Frog   509 KAEIPFSNV 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	41/221 (19%)
		CYCc	383..571	CDD:214485	65/194 (34%)
		Herpes_ICP4_C	794..>955	CDD:332854
adcy1	XP_002933461.1	AC_N	<37..282	CDD:292831	53/276 (19%)
		CYCc	248..443	CDD:214485	66/196 (34%)
		Guanylate_cyc	284..466	CDD:278633	62/184 (34%)
		CYCc	817..1028	CDD:214485
		Guanylate_cyc	850..1047	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910