Protein Alignment Glys and GYS1

DIOPT Version :10

• Sequence 1: NP_731967.2
• Gene: Glys / 41823
• FlyBaseID: FBgn0266064
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: NP_002094.2
• Gene: GYS1 / 2997
• HGNCID: 4706
• Length: 737
• Species: Homo sapiens
• Alignment Length: 689
• Identity: 402/689 - (58%)
• Similarity: 522/689 - (75%)
• Gaps: 25/689 - (3%)

  Fly    21 MNRRFSRVESGADLKDYFDRGDIASRENRWNFEVAWEVANKVGGIYTVIRSKAYVSTEEMGEQLC 85
            :||..| :.|...|:|:.|..|:   ||...|||||||||||||||||:::||.|:.:|.|:...
Human     3 LNRTLS-MSSLPGLEDWEDEFDL---ENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYF 63

  Fly    86 MMGPYKEHCARTEMEEMEFPRGNPLLD-AVNSLRSRGYKIHTGRWLVDGNPQLILFDIGSAAWKL 149
            ::|||.|...||::|.:|.|  .|.|. .::|:.|:|.|::.||||::|.|.::|.|:|::||.|
Human    64 LVGPYTEQGVRTQVELLEAP--TPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWAL 126

  Fly   150 DQFKSEMWEKCHIGIPHLDIETNDAIILGFMIAEFLEEFRNFAVTYSQNNELSAPRIVAHFHEWQ 214
            :::|.|:|:.|:||:|..|.|.|||::.||:...||.||      .:|:.|  .|.:|||||||.
Human   127 ERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEF------LAQSEE--KPHVVAHFHEWL 183

  Fly   215 AGVGLIVLRTRLVEIATVFTTHATLLGRYLCAGNTDFYNNLDKFAVDEEAGKRQIYHRYCLERGA 279
            |||||.:.|.|.:.:||:|||||||||||||||..||||||:.|.||:|||:||||||||:||.|
Human   184 AGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAA 248

  Fly   280 THLAHVFTTVSEITGYEAEHLLKRKPDIITPNGLNVKKFSAIHEFQNLHAVAKEKINEFVRGHFY 344
            .|.||||||||:||..||:|||||||||:||||||||||||:||||||||.:|.:|.||||||||
Human   249 AHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY 313

  Fly   345 GHIDFDLDKTLYFFIAGRYEFGNKGADIFIEALARLNAMLKHEKPDTTVVAFLIFPTKTNNFNVD 409
            ||:||:|||||||||||||||.|||||:|:|||||||.:|:....:.|||||.|.|.:||||||:
Human   314 GHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVE 378

  Fly   410 SLRGHAVIKQLRDTINNVQQAVGKRMFDTCLQGNIPNADDLLQKDDLVKIKRCMFAMQRDSMPPV 474
            :|:|.||.|||.||.|.|::..|::::::.|.|::|:.:.:|.|:|...:||.:||.||.|.|||
Human   379 TLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPV 443

  Fly   475 TTHNVADDWNDPVLSSIRRCHLFNSRHDRVKMVFHPEFLTSTNPLFGIDYEEFVRGCHLGVFPSY 539
            .|||:.||.:||:|::|||..||||..||||::||||||:||:||..:|||||||||||||||||
Human   444 CTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSY 508

  Fly   540 YEPWGYTPAECTVMGIPSVTTNLSGFGCFMEEHISDPKSYGIYIVDRRYIGLENSVQQLSSFMME 604
            ||||||||||||||||||::||||||||||||||:||.:|||||:|||:..|::|..||:||:..
Human   509 YEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYS 573

  Fly   605 FSRLNRRQRIIQRNRTERLSDLLDWRTLGIYYRQARVKALQAVYPD-YVDELSLYGSKNNLIFSR 668
            |.:.:||||||||||||||||||||:.||.||..||..||...:|: :..|.:...:.....:.|
Human   574 FCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPR 638

  Fly   669 PHSEPPSPTSSRHTTPAPSVHGSDDEDS-----VDEETE 702
            |.|.||||:.|||::|    |.|:||:.     ::|:.|
Human   639 PASVPPSPSLSRHSSP----HQSEDEEDPRNGPLEEDGE 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glys	NP_731967.2	Glycogen_syn	53..697	CDD:399009	389/650 (60%)
GYS1	NP_002094.2	Glycogen_syn	31..663	CDD:399009	389/645 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..737		17/44 (39%)