Protein Alignment GlyS and GYS1

DIOPT Version :9

• Sequence 1: NP_731967.2
• Gene: GlyS / 41823
• FlyBaseID: FBgn0266064
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: NP_002094.2
• Gene: GYS1 / 2997
• HGNCID: 4706
• Length: 737
• Species: Homo sapiens
• Alignment Length: 689
• Identity: 402/689 - (58%)
• Similarity: 522/689 - (75%)
• Gaps: 25/689 - (3%)

  Fly    21 MNRRFSRVESGADLKDYFDRGDIASRENRWNFEVAWEVANKVGGIYTVIRSKAYVSTEEMGEQLC 85
            :||..| :.|...|:|:.|..|:   ||...|||||||||||||||||:::||.|:.:|.|:...
Human     3 LNRTLS-MSSLPGLEDWEDEFDL---ENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYF 63

  Fly    86 MMGPYKEHCARTEMEEMEFPRGNPLLD-AVNSLRSRGYKIHTGRWLVDGNPQLILFDIGSAAWKL 149
            ::|||.|...||::|.:|.|  .|.|. .::|:.|:|.|::.||||::|.|.::|.|:|::||.|
Human    64 LVGPYTEQGVRTQVELLEAP--TPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWAL 126

  Fly   150 DQFKSEMWEKCHIGIPHLDIETNDAIILGFMIAEFLEEFRNFAVTYSQNNELSAPRIVAHFHEWQ 214
            :::|.|:|:.|:||:|..|.|.|||::.||:...||.||      .:|:.|  .|.:|||||||.
Human   127 ERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEF------LAQSEE--KPHVVAHFHEWL 183

  Fly   215 AGVGLIVLRTRLVEIATVFTTHATLLGRYLCAGNTDFYNNLDKFAVDEEAGKRQIYHRYCLERGA 279
            |||||.:.|.|.:.:||:|||||||||||||||..||||||:.|.||:|||:||||||||:||.|
Human   184 AGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAA 248

  Fly   280 THLAHVFTTVSEITGYEAEHLLKRKPDIITPNGLNVKKFSAIHEFQNLHAVAKEKINEFVRGHFY 344
            .|.||||||||:||..||:|||||||||:||||||||||||:||||||||.:|.:|.||||||||
Human   249 AHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFY 313

  Fly   345 GHIDFDLDKTLYFFIAGRYEFGNKGADIFIEALARLNAMLKHEKPDTTVVAFLIFPTKTNNFNVD 409
            ||:||:|||||||||||||||.|||||:|:|||||||.:|:....:.|||||.|.|.:||||||:
Human   314 GHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVE 378

  Fly   410 SLRGHAVIKQLRDTINNVQQAVGKRMFDTCLQGNIPNADDLLQKDDLVKIKRCMFAMQRDSMPPV 474
            :|:|.||.|||.||.|.|::..|::::::.|.|::|:.:.:|.|:|...:||.:||.||.|.|||
Human   379 TLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPV 443

  Fly   475 TTHNVADDWNDPVLSSIRRCHLFNSRHDRVKMVFHPEFLTSTNPLFGIDYEEFVRGCHLGVFPSY 539
            .|||:.||.:||:|::|||..||||..||||::||||||:||:||..:|||||||||||||||||
Human   444 CTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSY 508

  Fly   540 YEPWGYTPAECTVMGIPSVTTNLSGFGCFMEEHISDPKSYGIYIVDRRYIGLENSVQQLSSFMME 604
            ||||||||||||||||||::||||||||||||||:||.:|||||:|||:..|::|..||:||:..
Human   509 YEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYS 573

  Fly   605 FSRLNRRQRIIQRNRTERLSDLLDWRTLGIYYRQARVKALQAVYPD-YVDELSLYGSKNNLIFSR 668
            |.:.:||||||||||||||||||||:.||.||..||..||...:|: :..|.:...:.....:.|
Human   574 FCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPR 638

  Fly   669 PHSEPPSPTSSRHTTPAPSVHGSDDEDS-----VDEETE 702
            |.|.||||:.|||::|    |.|:||:.     ::|:.|
Human   639 PASVPPSPSLSRHSSP----HQSEDEEDPRNGPLEEDGE 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GlyS	NP_731967.2	Glycogen_syn	53..697	CDD:399009	389/650 (60%)
GYS1	NP_002094.2	Glycogen_syn	31..663	CDD:283373	389/645 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	634..737		17/44 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159982
Domainoid	1	1.000	814	1.000	Domainoid score	I68
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113557
Inparanoid	1	1.050	821	1.000	Inparanoid score	I471
Isobase	1	0.950	-	0	Normalized mean entropy	S379
OMA	1	1.010	-	-		QHG62683
OrthoDB	1	1.010	-	-		D218500at33208
OrthoFinder	1	1.000	-	-		FOG0003128
OrthoInspector	1	1.000	-	-		otm41479
orthoMCL	1	0.900	-	-		OOG6_103561
Panther	1	1.100	-	-	LDO	PTHR10176
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2141
SonicParanoid	1	1.000	-	-		X2097
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750