DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42788 and Magi3

DIOPT Version :10

Sequence 1:NP_731964.2 Gene:CG42788 / 41817 FlyBaseID:FBgn0261859 Length:1560 Species:Drosophila melanogaster
Sequence 2:NP_001152826.1 Gene:Magi3 / 99470 MGIID:1923484 Length:1476 Species:Mus musculus


Alignment Length:1354 Identity:280/1354 - (20%)
Similarity:442/1354 - (32%) Gaps:404/1354 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 TQSSGIPVTMATTATAMATATPDPSGCTE---VEGTASTELSTGLANETNCGTGIYGPLLGQSHG 153
            |:|.....|..:....|.::.|:.....:   |.|:.|.|.....:..::|..... |...|::.
Mouse   218 TESQRKRTTSVSKMERMDSSLPEEEEDEDKEAVNGSGSMETREMHSETSDCWMKTV-PSYNQTNS 281

  Fly   154 GVIAGMTENWPEIDGHLEAIQEKLKPGWSVHVGKEGRLYYCNHMTQSAGWLPA-----------C 207
            .:   ...|:...|.:|    |.|...|.:.....|.:|:.:|.|::..||..           |
Mouse   282 SM---DFRNYMMRDENL----EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDC 339

  Fly   208 EDWSKHEELSYGWERAIDSKGRSYYINHLNKTTTYEAP----------------------ECIRW 250
            ||    .||.||||:..|.:..:||::|||:.|.:|.|                      |...:
Mouse   340 ED----GELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQAEIHSAKTDVERAHF 400

  Fly   251 DEHPPEPRQVQLQ---RNASLGFGF-VAGSERP---VIVRFVTEGGPSI--GKLQPGDQILAVNG 306
            ...|.:.:.|.::   :.:::|||| :.|.:||   :.|:.|.:.||:.  ||:.|||.|:.:||
Mouse   401 TRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDING 465

  Fly   307 EDVKDAPRDHVIQLVR--ACESQVNLLVCQ--PM-------------AHCVLPGR---------- 344
            ..|.......|:|:.:  .....|||.:|:  |:             |..|:.|:          
Mouse   466 NCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMN 530

  Fly   345 ---------------KSTLLSAGKRAKLRSRPSRVRFAESVCVNGA--------PLFP-PSAFSL 385
                           ||..:.|..|....|..|..|  .|:..:|:        ||.. |..|..
Mouse   531 TQDFKLGAMVLDQNGKSGQILASDRLNGPSESSEQR--ASLASSGSSQPELVTIPLIKGPKGFGF 593

  Fly   386 -------------------------GDIC----------------------VPPMANVLKVFLEN 403
                                     |||.                      .|..|:|..:.|..
Mouse   594 AIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRG 658

  Fly   404 GQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRNKLTLLDPQESLARIAA--- 465
            |.....|...|.|.....|..|:.:    .|.....:....|:.|:....|||.|...:...   
Mouse   659 GPCSPTKTAKTKTDTKENSGSLETI----NEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYE 719

  Fly   466 --RPGAHKLRCL---------FRI-------------TFVPISAAELAQRDLHALDYLYLQCCND 506
              .|....|...         ||:             ..:|:.|||...| |.|.|.|   .|.|
Mouse   720 DKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGR-LRAADEL---MCID 780

  Fly   507 ----------------------------VNQERFAPELQPELALRLA-----ALHMHQHALANNF 538
                                        |.::.|..|.|||.....|     :..:::..|....
Mouse   781 GIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDESHQAFSQNGSPRLNRAELPTRS 845

  Fly   539 APAK---LTVKLVERE-FGLERFVPVSLFEGMKRKELRRLISHFLKLNAEMTGSSSKVLTQLQAK 599
            ||.:   :|::..|.| ||   ||.::    .|.|....:|.|  |:...:.||.:.....|:..
Mouse   846 APQEAYDVTLQRKENEGFG---FVILT----SKSKPPPGVIPH--KIGRVIDGSPADRCGGLKVG 901

  Fly   600 LHY----------------------------LDIIASLPSYGAKCFSTNQREGV----------- 625
            .|.                            |.::|....:|....:.:.|:..           
Mouse   902 DHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGTNSARQSPALQHRPMGQAQ 966

  Fly   626 ------ERVLLVSPRFGLSQISSARNSVQ-----PQPISAIEDFTHVVVNREDDVTCSVSIFMLG 679
                  :|:.| ....|....||.|:|..     .||.:|:   ..||.:|.:.        .||
Mouse   967 ANHIPGDRIAL-EGEIGRDVCSSYRHSWSDHKHLAQPDTAV---ISVVGSRHNQ--------SLG 1019

  Fly   680 DRAVKFIMEDRDGCEFSLVLGGYYRLLTGNVLNILREREPNDED----------NAPGFLSQHTV 734
            ...|:.....| |..|||..|..|.:  |..:..|.|..|..:|          ...|..:|...
Mouse  1020 CYPVELERGPR-GFGFSLRGGKEYNM--GLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT 1081

  Fly   735 LPAGWSYLLPFHTRAHSVNFLMAPPYHPLVQRGQLQQQSSIQAPSSL-PYVMDLDLHSVMATELL 798
                       ||||..           |:|.|..:....::..:.| |...|.|.:|..::.::
Mouse  1082 -----------HTRAIE-----------LIQAGGNKVLLLLRPGTGLIPDHGDWDTNSPSSSNVI 1124

  Fly   799 EEAAKDSGLSDSSGSNYCEGRSHLGSHQLEAKNEQVLRRVQELQHLVQTSEQYL--SEQEQGGGG 861
            .:.......|..|.|.:.|  ||:.:.:......|:..:.:||:..||..:..|  |:.|.....
Mouse  1125 YDEQPPPLPSSHSASTFEE--SHVPATEDSLTRVQICEKAEELKDTVQEKKSTLNGSQPEMKYQS 1187

  Fly   862 GGVAMLEFDSDCDSLNSSKVSSTEGSQGGTILGPGAIIPPGHPLKHSDSLTLLAETINHELSGIT 926
            ....|.:.|....|.:..| |..:|..|.|..|..| .|.....:||:          ..|..|.
Mouse  1188 VHKTMSKKDPPRGSGHGEK-SRLKGENGVTRRGRSA-SPKKSVNRHSE----------EHLEKIP 1240

  Fly   927 QGLNAIPESAPVSTSAPPTPATPKRKPSLCSTSSPRPQRKLNGFSQLLSDLQALGTDFSQSESDS 991
            :.|.:.|:......|..|.....|.:.::.:.|...|.||..|.|......|.:|   ..|.|::
Mouse  1241 RPLKSDPKEKSRDRSLSPRKGESKGRLTIKAGSGQDPNRKDRGRSSSPKKQQKIG---GNSLSNT 1302

  Fly   992 ESVASPAQSPTTRRPQMMLLQAAGSSAGSVAPAKQQLSQRSSFGLHSPDGTH-FGAETKDYNLRE 1055
            |...|.|.|   ||           :||....:.:||          |||.. .|...||     
Mouse  1303 EGKLSEAGS---RR-----------AAGHPRDSTEQL----------PDGREKSGVSRKD----- 1338

  Fly  1056 YLQQLK---------EISNAASADTDVAARQLSEIYGFEVRE------DTFIETDTDLIDLRAIP 1105
             |:|.:         |..::...:|.:.:::.|...|..|.|      .|..||..:.::...|.
Mouse  1339 -LKQSQPGKTRTKSPEKKSSKVDETSLPSKKTSSTAGRVVSEKEKGKKPTAGETSRETVEHTQIS 1402

  Fly  1106 PPQTPDEL-DSLSLMNAAPPKGFEGKAEELDSFLQQIMVAPPTQKATPAKELTP 1158
            ..|...|. :..:|.||...||.|  :|..|...::....|.:........:||
Mouse  1403 AKQLKQEAQEKTALGNADDHKGRE--SEVTDRCRERAGCTPQSSSLVKKAPITP 1454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42788NP_731964.2 WW 177..203 CDD:459800 6/25 (24%)
WW 218..246 CDD:238122 13/49 (27%)
PDZ_FRMPD1_3_4-like 259..333 CDD:467250 26/84 (31%)
FERM_F1_FRMPD1_like 393..482 CDD:340608 20/115 (17%)
B41 396..617 CDD:214604 59/312 (19%)
PH-like 613..715 CDD:473070 26/123 (21%)
PHA03247 <1105..1377 CDD:223021 13/55 (24%)
Magi3NP_001152826.1 PDZ0_MAGI-1_3-like 14..106 CDD:467212
Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:15652357 18..108
NK 125..>199 CDD:450170
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266 9/47 (19%)
HUL4 <211..>373 CDD:227354 41/166 (25%)
WW 297..329 CDD:197736 8/31 (26%)
WW 345..375 CDD:238122 13/29 (45%)
PDZ1_MAGI-1_3-like 411..495 CDD:467213 25/83 (30%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 25/81 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..575 7/25 (28%)
PDZ2_MAGI-1_3-like 577..658 CDD:467214 11/80 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 664..691 6/30 (20%)
PDZ3_MAGI-1_3-like 727..811 CDD:467215 15/87 (17%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 14/85 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..844 5/25 (20%)
PDZ4_MAGI-1_3-like 851..936 CDD:467216 17/93 (18%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 18/95 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..966 2/26 (8%)
PDZ5_MAGI-1_3-like 1020..1102 CDD:467217 22/106 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1109..1151 9/43 (21%)
PTZ00112 1115..>1404 CDD:240274 73/335 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1476 76/334 (23%)
Blue background indicates that the domain is not in the aligned region.

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