Protein Alignment CG42788 and MAGI2

DIOPT Version :9

• Sequence 1: NP_731964.2
• Gene: CG42788 / 41817
• FlyBaseID: FBgn0261859
• Length: 1560
• Species: Drosophila melanogaster
• Sequence 2: XP_016868329.1
• Gene: MAGI2 / 9863
• HGNCID: 18957
• Length: 1540
• Species: Homo sapiens
• Alignment Length: 1691
• Identity: 308/1691 - (18%)
• Similarity: 489/1691 - (28%)
• Gaps: 729/1691 - (43%)

  Fly    75 NGSVVHATPTRSN--GCPLTQSSGIPVTMATTATAMATATPDPSG------------CTEVEGTA 125
            :|:::.:.....|  |.|...:...|:.:..|...:..|||...|            ...:|...
Human   169 SGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPE 233

  Fly   126 STELSTGLANETNCGTGIYGPLLGQSHGGVIAGMTENWPE------IDGHLEAIQEKL------K 178
            ..|....:.|    |.|:........|....||.:...|.      :....|.::|::      |
Human   234 EEEEERPVVN----GNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTK 294

  Fly   179 P-----------GWSVHVGKEGRLYYCNHMTQSAGWL---------PACEDWSKHEELSYGWERA 223
            |           .|.:...::|.:|:.:|.|::..||         |..|  .|..||.||||:.
Human   295 PEDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEE--CKENELPYGWEKI 357

  Fly   224 IDSKGRSYYINHLNKTTTYE----------------------------------------APECI 248
            .|....:||::|:|:.|.:|                                        .|:.|
Human   358 DDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFRVDSSSWTLPRPKSI 422

  Fly   249 RWDEHPPEPRQV---------------------------QLQ--------RNASLGFGF-VAGSE 277
            |....|...|.|                           ||:        :.:::|||| :.|.:
Human   423 RPRAAPERSRSVNDLSYYQRDPAGRPWLFEKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGD 487

  Fly   278 RP---VIVRFVTEGGPSI--GKLQPGDQILAVNGEDVKDAPRDHVIQLVRACE--SQVNLLVCQP 335
            .|   :.|:.|...||:.  ||::.||.|:.:|...|.......|::|.::..  ..|||::|:
Human   488 EPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCR- 551

  Fly   336 MAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPL-FPPS--AFSLGDICVPPMANVL 397
                                                  |.|| |.|.  |.|:    |||:|.:.
Human   552 --------------------------------------GYPLPFDPEDPANSM----VPPLAIME 574

  Fly   398 K--VFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRNKLTLLDPQESL 460
            :  ..:.||:..                            :...||::..          ..:|:
Human   575 RPPPVMVNGRHN----------------------------YETYLEYISR----------TSQSV 601

  Fly   461 ARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAPELQPELALRLA 525
            ..|..|| .|.|..:      |...         .||..|            .|.:..:
Human   602 PDITDRP-PHSLHSM------PTDG---------QLDGTY------------PPPVHDD------ 632

  Fly   526 ALHMHQHALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLISHFLKLNAEMTGSSS 590
                                                                    |..|..|.:
Human   633 --------------------------------------------------------NVSMASSGA 641

  Fly   591 KVLTQLQAKLHYLDIIASLPSYGAKCFSTNQREGVERVLLVSPRFGLSQ----ISSARNSVQPQP 651
                 .||:|..|.|:.....:|.....:...:.|:::|.:....||.:    :...:.:||
Human   642 -----TQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQ--- 698

  Fly   652 ISAIEDFTHVVVNREDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVL--GGYY------RLLTG 708
                 :.:|..|           :.:|.|..:        |.|.||::  ||::      :.:..
Human   699 -----NLSHTEV-----------VDILKDCPI--------GSETSLIIHRGGFFSPWKTPKPIMD 739

  Fly   709 NVLNILREREPNDEDNAPGFLSQHTVLPAGWSYLLPFHTRAHSVNF---------LMAPPYHPLV 764
            ...|   :..|....:||       .:|..    |||....|..:|         ....||....
Human   740 RWEN---QGSPQTSLSAP-------AIPQN----LPFPPALHRSSFPDSTEAFDPRKPDPYELYE 790

  Fly   765 Q-------RGQLQQQSSIQAPSSLPYVMDLDLH-----SVMATELL--EEAAKD--SGLSDSSGS 813
            :       |.|:..::|.:..||.|...:||:|     |.....:|  :|..:.  .|...:.||
Human   791 KSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGS 855

  Fly   814 NYCEGRSHLG--------------SHQL-------EAKNEQVLRRVQE----------------- 840
            ...:||.|.|              :|:.       .|:|.||...|:.
Human   856 ADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPG 920

  Fly   841 ----------------------------------LQHLVQTSEQYLSEQEQGGGGGGVAMLEFDS 871
                                              ..|.:|||:..:..:|..|.|..:
Human   921 SVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVI------- 978

  Fly   872 DCDSLNSSKVSSTEGSQGGTILGP---GAIIPPGHP-----------------------LKHSDS 910
             ..|||..:       .|.||..|   |.|| .|.|                       :.|:|.
Human   979 -ISSLNRPE-------SGSTITVPHKIGRII-DGSPADRCAKLKVGDRILAVNGQSIINMPHADI 1034

  Fly   911 LTLLAETINHELSGITQGLNAIPE-------SAPVSTS----------------APPTPATPKRK 952
            :.|:.:      :|::..|..||:       |||.|..                |.|:||||  .
Human  1035 VKLIKD------AGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATP--N 1091

  Fly   953 PSLCSTSSPRPQRKLNGFSQLLSDLQALGTDFS-QSESDSESVASP--AQSPTT--RRPQMMLLQ 1012
            ..:...:.|:|             ||..|.:.| :||..:.....|  .|.|.|  |:|.:...|
Human  1092 SPIAQPAPPQP-------------LQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQ 1143

  Fly  1013 AAGSSAGSVAPAKQQLSQRSSFGLHSPDGTHFGAETKDYNLREYLQQLKEISNAASADTDVAARQ 1077
            ..|.......|...:......:..||||       |:.|.|.:|.|  .:..:..:.|.:..|:.
Human  1144 PPGGDYQQPPPLDYRQPPLLDYRQHSPD-------TRQYPLSDYRQ--PQDFDYFTVDMEKGAKG 1199

  Fly  1078 LSEIYGFEVR------EDTFI--------------------------ETDTDLIDLRAIP----- 1105
                :||.:|      .|.::                          |:..|:...|||.
Human  1200 ----FGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSG 1260

  Fly  1106 -----------PPQTPD---ELDSLSL-----MNAAP-------PKGFE-GKAEELDSFLQQIMV 1143
                       ..|.|:   ...|||:     .:.:|       ||..| .|....|:  ::...
Human  1261 GRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTERSKLARTDN--RKDEP 1323

  Fly  1144 APPTQKATPAKELTPEEIMSF---IIP-----PPPNLEQQQVVAPVETECLYSNSVQAKREFFQS 1200
            ||.:..|..|..| ||..:|.   :.|     |.|..:....::|..|       ...|||
Human  1324 APWSSPAAAAPGL-PEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPT-------WDIKRE---- 1376

  Fly  1201 VANGNNGTVSHSPHIIEYATVERKSKFSCCPTSKK--------------------EEQPGQEELQ 1245
                      |.        |.:..:.|.|...|:                    ||.||.:. :
Human  1377 ----------HD--------VRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEEAPGGQG-R 1422

  Fly  1246 PPPRTPTTEQLSPPPARPPKSAELLQRYSPKKQVRIAASPVMQPQERRELC----PPQLPPRGSP 1306
            |....|.:|..:|..|  ...|....|...|:..|.||.        .|||    |...|....|
Human  1423 PEAGRPASEARAPGLA--AADAADAARAGGKEAPRAAAG--------SELCRREGPGAAPAFAGP 1477

  Fly  1307 TLDGSQSSPTNAVSGPKKPPLPPIACRPRPSNGVNSPNSSSPGSAP--PAHYSP---PIPATVRL 1366
            ...||.:......:|.:..|.|    .|||           ||.||  .|..:|   .:|.:.:|
Human  1478 GGGGSGALEAEGRAGARAGPRP----GPRP-----------PGGAPARKAAVAPGPWKVPGSDKL 1527

  Fly  1367 P 1367
            |
Human  1528 P 1528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809	7/42 (17%)
		WW	218..246	CDD:238122	11/67 (16%)
		PDZ_signaling	257..333	CDD:238492	26/118 (22%)
		B41	396..617	CDD:214604	24/222 (11%)
		UBQ	396..477	CDD:294102	10/82 (12%)
		FERM_M	495..617	CDD:278785	13/121 (11%)
		PH-like	613..715	CDD:302622	18/113 (16%)
MAGI2	XP_016868329.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010