DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42788 and FRMPD3

DIOPT Version :9

Sequence 1:NP_731964.2 Gene:CG42788 / 41817 FlyBaseID:FBgn0261859 Length:1560 Species:Drosophila melanogaster
Sequence 2:NP_115804.1 Gene:FRMPD3 / 84443 HGNCID:29382 Length:1810 Species:Homo sapiens


Alignment Length:1341 Identity:346/1341 - (25%)
Similarity:543/1341 - (40%) Gaps:269/1341 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 PACEDWSKHEELSYGWERAIDSKGRSYYINHLNKTTTYEAPECIRWDEHPPE-PRQVQLQRNASL 268
            |.|...|..:||               :.:|:.:..:....||   ::.|.| .|||.:.|:...
Human    17 PGCSSPSGQQEL---------------FSSHVMQEESANDMEC---EQLPAEILRQVTVHRDPIY 63

  Fly   269 GFGFVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHVIQLVRACESQVNLLVC 333
            ||||||||||||:||.|..||||..||..||||:|:|.|||.:|||:.:|:|:|:.:..:.|.|.
Human    64 GFGFVAGSERPVVVRSVRPGGPSENKLLAGDQIVAINEEDVSEAPRERLIELIRSAKEFIVLTVL 128

  Fly   334 QPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCV--NGAPLFPPSAFSLGDICVPPMANV 396
            .  .|   ...||..:||.|:|||||.|.:|||:|.|.|  ..|.:....|..|    :|   ||
Human   129 H--TH---QSPKSAFISAAKKAKLRSNPVKVRFSEQVAVGETDAKMMKKEALLL----IP---NV 181

  Fly   397 LKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRNKLTLLDPQESLA 461
            |||||||||.|||.:|..|||:||:.:|.|:|.|...|.|:||||:....:.:|..||..::.||
Human   182 LKVFLENGQIKSFTFDGRTTVKDVMLTLQDRLSLRFIEHFALVLEYAGPEQNHKFLLLQDKQPLA 246

  Fly   462 RIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAPELQPELALRLAA 526
            .:..|...|.::|||||:|.|....||.:||..|.:|||:|..|||.:|||..:.:||:.|.|||
Human   247 YVVQRTHYHGMKCLFRISFFPKDPVELLRRDPAAFEYLYIQSRNDVIRERFGMDPKPEMLLGLAA 311

  Fly   527 LHMHQHALANNFAPA-KLTVKLVEREFGLERFVPVSLFEGMKRKELRRLISHFLKLNAEMTGSSS 590
            ||::....|..  |: |:::|.||:|:|||.|:|.||.:.:|.|.||:.:|..||.:.......:
Human   312 LHIYITVSATR--PSQKISLKNVEKEWGLEPFLPPSLLQVIKEKNLRKSLSQQLKAHQTHPSCGT 374

  Fly   591 KVLTQLQAKLHYLDIIASLPSYGAKCFST---NQREGVERVLLVSPRFGLSQISSARNSVQPQPI 652
            |. :.:||||.||.|:..||::....|:|   ::::.. ..|||.||.|:|.:...:.:: ...:
Human   375 KG-SAIQAKLQYLRILNELPTFTGVLFNTVGLDEKQSA-TTLLVGPRHGISHVIDLKTNL-TTVL 436

  Fly   653 SAIEDFTHVVVNREDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVLGGYYRLLTGNVLNILRER 717
            |.....:.:.:.||:.....|...::..:.:..:||..:...|:.::.||.|||..:...:.  .
Human   437 SEFSKISKIQLFRENQGVARVETSIMDAKPLVLLMEWPEATNFACLIAGYCRLLLDSRKMVF--S 499

  Fly   718 EPNDEDNAPGFL------SQHTVLPAGW------SYLLPFHTRAHSVNFLMAPP----------Y 760
            .|..:...|..:      |.|..:..|.      ||:....|.....:....||          .
Human   500 RPASQPLPPPMIKADYMHSAHRPVTGGHLGKKESSYVGSVGTSPRKSSRCTPPPADSELVSFCYL 564

  Fly   761 HPLVQRGQLQQQSSIQAPSSLPYVMDLDLHSVMATELLEEAAKDSGLSDSSGSNY---------- 815
            |...||.:.:.::.:.             .:::..|......|....|.|||..|          
Human   565 HMREQRKEQESRTDVN-------------ENLIFFEETRPRTKSDPTSKSSGQGYEVVPDDFDAA 616

  Fly   816 ------CEGRSH-------LGSHQLEAKNEQVLRRVQELQHLVQTSEQYLSEQEQGGGGGGVAML 867
                  |..|:.       ||:..|....:....::||               :.|...||....
Human   617 SLDHEPCASRARSYTLDNSLGAEALNFYCDSCKAKLQE---------------QLGPRKGGKPGS 666

  Fly   868 EFDSDCDSLN----SSKVSSTEGSQGGTILGPGAIIPPGHPLKHSDS------------------ 910
            ..|:..|.::    .|:....|..:..::|...|..|||.....||.                  
Human   667 SRDNIVDLMSLPPPGSEEEEEEEDETTSLLPAIAAPPPGFRDNSSDEDDPKRRAVQSQEQGRHLR 731

  Fly   911 --------LTLL-----------AETINHELSGITQGLNAI--PESAPVSTSAPPTPATPKRKPS 954
                    :||:           |:.::..|....|.|.|:  .|..|    .||.|.|    ..
Human   732 GLLYDEIPVTLIDSVQTRTVRDHAQELDDALVSTLQALEALAASEDGP----HPPPPQT----AG 788

  Fly   955 LCSTSSPRPQRKLNG----FSQLLSDLQALGTDFSQSESDSESVAS--PAQSPTTRRPQMMLLQA 1013
            |...::..|:..|:.    .|..|:|:..:.:...|.::.:..:|.  ...|...|:.....:|:
Human   789 LIVLATITPESSLDSGHETNSSELTDMSEMMSAMKQHQNTTYFLAQHLNKDSLLARKDLPFRIQS 853

  Fly  1014 AGSSAGSVAPAKQQLSQRSSFGLHSPDGTHFGAETKDYNLREYLQQLKEISNAASADTDVAARQL 1078
            ..:.|...||          :.|..||..               ..|:.|:...|.....|.|:|
Human   854 CAAQAVLTAP----------YSLGRPDPN---------------PSLQPIATGQSPGPPGARRKL 893

  Fly  1079 SEIYGFEVREDTFIETDTDLIDLRAIPPPQTP--DELDSLSLMNAAP-PKGFEGKAEELDSFLQQ 1140
            .:..|....|.|:         ..|:.|..:|  .|..:|||::..| .||.......|:..|:.
Human   894 PQSEGQVQGERTY---------SLAVHPALSPQLSEQKNLSLLSPVPEDKGPGHTRAGLEMSLRA 949

  Fly  1141 IMVAPPTQKATPAKELTPEEIMSFIIPPPPNLEQQQVVAPVETECLYSNSVQAKREFFQSVANGN 1205
            ...:...::.:..::..|:|:.   :.|...|:.:..|.|..........|..|.......|.||
Human   950 ATSSLSEEQVSELRDNLPKEVR---LSPKLILDPKSSVTPAIISAALQQVVHNKSLVTAGGALGN 1011

  Fly  1206 ---------NGTVSHSPHIIEYATVERKSKFSCCPTSKKEEQPGQE----ELQPPPRTPTTEQLS 1257
                     ..::......:..::..:..||...|::.:.....|.    |:...||.||..:..
Human  1012 PPSRGERRLEASMGRPEVSMMSSSASKNLKFKISPSAPETSWNSQHQLGAEVSSSPRAPTGSRAD 1076

  Fly  1258 PPPARPPKSAELLQRYSPKKQVRIAASPVMQPQERRELCPPQLPPRGSPTLD-----GSQSSPTN 1317
            .......:.:..:|.:.||..:...:...:..|...|:.....|..|.|||.     .||.....
Human  1077 SLHLSQQEDSLPVQNFPPKSYLLRTSRESVGKQATGEVAGKGGPVGGKPTLQKQGTISSQGEKAQ 1141

  Fly  1318 AVSGPKKPPLP----------PIA-----CRPR---PS---NGVNSPNSSSPGSAP---PAHYSP 1358
            ..|.||:..|.          |:|     |:.|   ||   :| :||:|.|.|.:|   |...||
Human  1142 LESTPKRSKLEETSLVPRATYPMALQSPSCQSRSHSPSCQPHG-HSPSSQSRGQSPSCQPRGQSP 1205

  Fly  1359 -----------PIPATVRLPHLNQANGTLPLLPKKPQQLHG 1388
                       .:|:......||.|:.|.. .|.||:...|
Human  1206 LRSQAASRQVSTMPSRKLETTLNGAHSTSE-GPAKPKSSRG 1245

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42788NP_731964.2 WW 177..203 CDD:278809
WW 218..246 CDD:238122 1/27 (4%)
PDZ_signaling 257..333 CDD:238492 41/75 (55%)
B41 396..617 CDD:214604 97/221 (44%)
UBQ 396..477 CDD:294102 38/80 (48%)
FERM_M 495..617 CDD:278785 50/122 (41%)
PH-like 613..715 CDD:302622 21/104 (20%)
FRMPD3NP_115804.1 PDZ_signaling 52..128 CDD:238492 41/75 (55%)
B41 181..400 CDD:214604 97/221 (44%)
FERM_M 276..400 CDD:278785 52/126 (41%)
FERM_C_FRMPD1_FRMPD3_FRMPD4 396..499 CDD:270004 21/106 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..553 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 588..607 5/18 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..730 14/74 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 865..904 10/53 (19%)
DUF4671 1000..>1378 CDD:292338 54/248 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1047..1249 47/201 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1342..1379
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1765..1798
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159435
Domainoid 1 1.000 124 1.000 Domainoid score I5522
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41241
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4089
SonicParanoid 1 1.000 - - X1331
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.870

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