Protein Alignment CG42788 and frmpd3

DIOPT Version :10

• Sequence 1: NP_731964.2
• Gene: CG42788 / 41817
• FlyBaseID: FBgn0261859
• Length: 1560
• Species: Drosophila melanogaster
• Sequence 2: XP_005157236.1
• Gene: frmpd3 / 798302
• ZFINID: ZDB-GENE-100316-9
• Length: 1696
• Species: Danio rerio
• Alignment Length: 1700
• Identity: 399/1700 - (23%)
• Similarity: 630/1700 - (37%)
• Gaps: 496/1700 - (29%)

  Fly   254 PPEPRQVQLQRNASLGFGFVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHVI 318
            |...|:|.:||:.|.||||:|||||||:||.|:..|||.|||.|||||||:|.|.|.|.||:.||
Zfish    32 PGLTREVCIQRHPSHGFGFIAGSERPVVVRSVSADGPSSGKLYPGDQILAINQELVSDVPREKVI 96

  Fly   319 QLVRACESQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLFPPSAF 383
            .|||.|...:.|.|.||.     ...||..:||.|:|:||:.|.:|||:|.|.::     .|.:.
Zfish    97 DLVRCCRDSIVLTVLQPQ-----QSPKSAFISAAKKARLRTNPPKVRFSEQVSIS-----DPDST 151

  Fly   384 SLGDICVPPMANVLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKR 448
            .|.|..:..:.|||||||||||.|||.:|:.|||:||:|||.|:|.|...|.|:||||.....:.
Zfish   152 MLKDDSLLLIPNVLKVFLENGQIKSFTFDSRTTVRDVISSLQDRLSLRYIEHFALVLESGGLAQN 216

  Fly   449 NKLTLLDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFA 513
            .:|.||...:.|:.:..|.....::|||||.|.|...::|.:||..|.:|||:|..|||.:|||.
Zfish   217 QRLHLLQENQPLSHVVHRTYFQGMKCLFRICFFPKDPSDLLRRDPAAFEYLYIQSRNDVIKERFG 281

  Fly   514 PELQPELALRLAALHMH---QHALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLI 575
            .:.:.::.|||||||::   ..|..|.    |:::|.||:|:|||.|:|::|...:|.|.:.:.:
Zfish   282 MDWKFDVTLRLAALHIYITVSIARPNQ----KISLKHVEKEWGLEPFLPLALLPTIKEKNVCKTL 342

  Fly   576 SHFLKLNAEMTGSSSKVLTQLQAKLHYLDIIASLPSYGAKCFST---NQREGVERVLLVSPRFGL 637
            |..||.......:.:|| :.||.||.|:.::..||.:|...|.|   ::::.. ..|||.||.|:
Zfish   343 SQLLKTYQHPPPAGNKV-SPLQGKLQYMRVLNDLPPFGGFLFHTVGLDEKQSA-TTLLVGPRHGI 405

  Fly   638 SQISSARNSVQPQPISAIEDFTHVV---VNREDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVL 699
            |.:...:|::    .:.:.:|:.|.   :.||......|.:.:|..:.:..:||..|...|:.::
Zfish   406 SHVIDLKNNL----TTVLAEFSRVAKVQLFREHHGVARVEVVILDAKPLVLLMEWPDASNFACLI 466

  Fly   700 GGYYRL-----------LTGNVLNILREREPNDEDNAPGFLSQHTVLPAGWSYLLPFHTRAHSVN 753
            .|||:|           :.|....|..:...:......|    .|||...........:|..:..
Zfish   467 SGYYKLFVDPKRTIYCRIPGQPYVIKADCRSSHAQTRSG----ATVLSGSAREERETSSRETTQK 527

  Fly   754 FLMAP-PYH------PLVQRGQLQQQSSIQAPSSLPYVMDLDLHSVMATEL-------------- 797
            ...:| |.|      .|.::.|| |:..|||.      .:||::..:.:::
Zfish   528 TSASPIPQHLGLCHIHLKEQQQL-QEFQIQAE------QELDVNENLISQVQSRSRTKSDPTLKS 585

  Fly   798 LEEAAKDSGLSDSSGS----------------NYCEGRSHLGSHQLEAKNEQVLRRVQELQHLV- 845
            .|..|:..|.::.|.|                .:|:.:       |:|  |.::::..|...|:
Zfish   586 TESVAEHDGPTEESSSFRNRAKTLEPSQKFFCEFCKAK-------LQA--EGIIQKTGETGRLIL 641

  Fly   846 QTSEQYLSEQEQGGGGGGVAML-------EFDSDCDSLNSSKVSSTEGSQGGTILGPG-----AI 898
            |......|.:|    ||.|.::       |.|.:.:             .||..|.|.     |.
Zfish   642 QQCTNACSSRE----GGAVDLIALPLPGNEEDEEIE-------------DGGGKLQPPTHAAIAA 689

  Fly   899 IPPGHPLKHSDS------------------------LTLL-----------AETINHELSGITQG 928
            .|||.....||.                        :||:           |:.::..|....|.
Zfish   690 PPPGFRDNSSDEDDPKKGRKGIKASTAVAQGQDEVPVTLIDNVTTRTVQDHAQELDDALVSTLQA 754

  Fly   929 LNAIPESAPVSTSAPPTPATPKRKPSLCSTSSPRPQRKLNG----FSQLLSDLQALGTDFSQSES 989
            |.|:..|.........||.|    ..|...::..|:..|:.    .|..|:|:..:.:...|.::
Zfish   755 LEALAASEDYPHHQQQTPQT----TGLIVLAAITPESSLDSGHETNSSELTDVSEMVSAMKQHQN 815

  Fly   990 DSESVASPAQSPT--TRRPQMMLL-----QAAGSSA-------GSVAPAKQQLSQRSSFGL---- 1036
            .:..:|.......  :||...:.:     ||.|..|       ||..|....||:.....:
Zfish   816 QAYLLAHHINKERLFSRRDFPLTIPGCTTQAIGGGAFSMSQIRGSCPPKPVILSKTLPLKISPNK 880

  Fly  1037 ---HSPDGTHFGAETKDYNLREYLQQLKEISNAASADTDVAARQLSEIYGFEVREDTFIETDTDL 1098
               ||.....:|.                 |:.|:.:.|:...:...:  .|..|::.::...
Zfish   881 EISHSDKSAEWGK-----------------SHEANGEKDIEITEKGLV--TECLEESKLQISE-- 924

  Fly  1099 IDLRAIPPPQTPDELDSLSLMNAAPPKGF--EGKAEE------LDSFLQQIMVAPPTQKATPAK- 1154
             :|:|......|.....|.|.|...|...  ||..||      |::....:.|..|..:.|.||
Zfish   925 -ELKAPEHGSAPQVNTELLLANEEKPSTITSEGAQEEDSCAKTLETTSIALPVLLPVDRTTSAKI 988

  Fly  1155 --------------ELTPEEIMSFIIP---------------PPPNLEQQQV--------VAPVE 1182
                          |.|.......::|               |...|:..||        ::|.:
Zfish   989 CSTNRCQDAKNASSETTKPSSSKGLLPTADLFCTCPIRPEPGPQVRLKDPQVQKLVVFHSLSPTD 1053

  Fly  1183 TECLYSNSVQAKREFFQSVANGNNGT------VSHSPHIIEYATVERKSKFSCCPTSKKEEQPGQ 1241
            .|.|::..:|..:|.....::.:..|      ..:||  :..|.||:|........:.:.:.|
Zfish  1054 DERLHAKGLQLAKEDTAKTSDASLVTPNTLPSTKYSP--VMSAKVEKKEMSEAKAENSQSKSP-- 1114

  Fly  1242 EELQP-----PPRTPTTEQLS-------PPPARPPKSAE---LLQRYSPKKQVRIAASPVM---- 1287
            .|:|.     |.....|..||       .|.|...|.|.   ..||.:|....|...|...
Zfish  1115 VEIQKVAKSLPVNVDPTHMLSCVEKGATIPGAEYKKQANNKGKSQRSTPFLSFRNLISATFPARL 1179

  Fly  1288 --QPQERR---------------ELCPP-----QLPPRGS-------PTLDGSQSSPTNAVSGPK 1323
              :..|||               ||..|     :..|:||       |.....::||...|.|..
Zfish  1180 RRETDERRAQLQKVRQYELEFLEELLKPKTSQGEFLPQGSSPVPSFTPCACQLRTSPVQKVPGIS 1244

  Fly  1324 KPPLPPIACRPRPSNGVNSPN----------------SSSPGSAPPAHYSP-------------- 1358
            :.......|: |...|:..|:                |.:|.:.|.:.::|
Zfish  1245 REQRRSCDCK-RMCRGMRLPDTAVGSATEQRGRERAISKTPPAIPKSPHTPQGELQKNQTLEIKT 1308

  Fly  1359 --------------PIPA-----------TVRLPHLN-----------QANGTLPL--------- 1378
                          .||.           ::..||..           :.||:.||
Zfish  1309 TRIRSTSLESREPRDIPTSCLPMCTTRTESIGAPHYKKLQRRYSIGEIENNGSTPLYAEVKTTKA 1373

  Fly  1379 ----------------LPKKPQQLH-----GEKLFIKNG-------------------------- 1396
                            ||...:.:|     .:|:|...|
Zfish  1374 KSLEKEMERVRATGLRLPTPVEPVHTKDGDAKKIFYIQGEEILQESREGTAEVLGLPSEDTEDRE 1438

  Fly  1397 ------------------------------HLIDGEALLAKTDVAMSGLLIKLDQVAAQCSVAQA 1431
                                          .::.|..|.::|...:|..|..||  |..|.
Zfish  1439 KCCSFCFCYRKCEAADESSEKDELSYSIPLQVLPGMHLDSRTMPVISKTLQVLD--AEDCC---- 1497

  Fly  1432 AGGGTSIDEEKFQRARNELTEQTLALVTASKFLVASMSDMTLITLPEHLTSC-------LTAIRR 1489
              |...:.||:.|..|.:|  :....:.||...|.|:.|.| .:||:...:.       |:.:|:
Zfish  1498 --GEEEVQEEEPQTQRIDL--RVCGNLEASLARVKSLQDKT-FSLPDGFLNAQLDANELLSILRQ 1557

  Fly  1490 ITELAQ--DMTRHTSAPL--QTRNIVLKVHDVASSFRELVGVEIGP---IGAGQLALQAEC-LAN 1546
            .....|  ...|..||.|  ..:.:.::..:..:|.|.:..||..|   :.|...:.|..| |..
Zfish  1558 CANSPQIEGEPRIPSATLAEYKQELAVRFKEFRASCRRVASVEKSPSRMLSAVTASFQVLCNLTQ 1622

  Fly  1547 VLATLLRSLR 1556
            ....|:|.:|
Zfish  1623 TFIQLVRGVR 1632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:459800
		WW	218..246	CDD:238122
		PDZ_FRMPD1_3_4-like	259..333	CDD:467250	44/73 (60%)
		FERM_F1_FRMPD1_like	393..482	CDD:340608	43/88 (49%)
		B41	396..617	CDD:214604	92/223 (41%)
		PH-like	613..715	CDD:473070	27/118 (23%)
		PHA03247	<1105..1377	CDD:223021	78/437 (18%)
frmpd3	XP_005157236.1	PDZ_FRMPD1_3_4-like	37..111	CDD:467250	44/73 (60%)
		FERM_F1_FRMPD3	161..253	CDD:340689	44/91 (48%)
		B41	164..383	CDD:214604	92/223 (41%)
		FERM_C_FRMPD1_FRMPD3_FRMPD4	379..481	CDD:270004	25/106 (24%)