Protein Alignment CG42788 and frmpd3

DIOPT Version :9

• Sequence 1: NP_731964.2
• Gene: CG42788 / 41817
• FlyBaseID: FBgn0261859
• Length: 1560
• Species: Drosophila melanogaster
• Sequence 2: XP_021328436.1
• Gene: frmpd3 / 798302
• ZFINID: ZDB-GENE-100316-9
• Length: 1715
• Species: Danio rerio
• Alignment Length: 1717
• Identity: 403/1717 - (23%)
• Similarity: 626/1717 - (36%)
• Gaps: 511/1717 - (29%)

  Fly   254 PPEPRQVQLQRNASLGFGFVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHVI 318
            |...|:|.:||:.|.||||:|||||||:||.|:..|||.|||.|||||||:|.|.|.|.||:.||
Zfish    32 PGLTREVCIQRHPSHGFGFIAGSERPVVVRSVSADGPSSGKLYPGDQILAINQELVSDVPREKVI 96

  Fly   319 QLVRACESQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLFPPSAF 383
            .|||.|...:.|.|.||.     ...||..:||.|:|:||:.|.:|||:|.|.::     .|.:.
Zfish    97 DLVRCCRDSIVLTVLQPQ-----QSPKSAFISAAKKARLRTNPPKVRFSEQVSIS-----DPDST 151

  Fly   384 SLGDICVPPMANVLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKR 448
            .|.|..:..:.|||||||||||.|||.:|:.|||:||:|||.|:|.|...|.|:||||.....:.
Zfish   152 MLKDDSLLLIPNVLKVFLENGQIKSFTFDSRTTVRDVISSLQDRLSLRYIEHFALVLESGGLAQN 216

  Fly   449 NKLTLLDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFA 513
            .:|.||...:.|:.:..|.....::|||||.|.|...::|.:||..|.:|||:|..|||.:|||.
Zfish   217 QRLHLLQENQPLSHVVHRTYFQGMKCLFRICFFPKDPSDLLRRDPAAFEYLYIQSRNDVIKERFG 281

  Fly   514 PELQPELALRLAALHMH---QHALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLI 575
            .:.:.::.|||||||::   ..|..|.    |:::|.||:|:|||.|:|::|...:|.|.:.:.:
Zfish   282 MDWKFDVTLRLAALHIYITVSIARPNQ----KISLKHVEKEWGLEPFLPLALLPTIKEKNVCKTL 342

  Fly   576 SHFLKLNAEMTGSSSKVLTQLQAKLHYLDIIASLPSYGAKCFST--------------------- 619
            |..||.......:.:|| :.||.||.|:.::..||.:|...|.|
Zfish   343 SQLLKTYQHPPPAGNKV-SPLQGKLQYMRVLNDLPPFGGFLFHTVGLDEKQSATTLLVGPSHGIS 406

  Fly   620 NQREGVERVLLVSPRFGLSQISSARNSVQPQPISAIEDFTHVV---VNREDDVTCSVSIFMLGDR 681
            ::.:.....|||.||.|:|.:...:|::    .:.:.:|:.|.   :.||......|.:.:|..:
Zfish   407 HEEKQSATTLLVGPRHGISHVIDLKNNL----TTVLAEFSRVAKVQLFREHHGVARVEVVILDAK 467

  Fly   682 AVKFIMEDRDGCEFSLVLGGYYRL-----------LTGNVLNILREREPNDEDNAPGFLSQHTVL 735
            .:..:||..|...|:.::.|||:|           :.|....|..:...:......|    .|||
Zfish   468 PLVLLMEWPDASNFACLISGYYKLFVDPKRTIYCRIPGQPYVIKADCRSSHAQTRSG----ATVL 528

  Fly   736 PAGWSYLLPFHTRAHSVNFLMAP-PYH------PLVQRGQLQQQSSIQAPSSLPYVMDLDLHSVM 793
            ...........:|..:.....:| |.|      .|.::.|| |:..|||.      .:||::..:
Zfish   529 SGSGREERETSSRETTQKTSASPIPQHLGLCHIHLKEQQQL-QEFQIQAE------QELDINENL 586

  Fly   794 ATELLEEAAKDSGLSDSSGSNYCEGRSHLG--SHQLEAKNEQVLRRVQELQHLVQTSEQYLSE-- 854
            .:::...:...|..:..|..:..|   |.|  ...|..:|     |.:.|    :||:::..|
Zfish   587 ISQVQSRSRTKSDPTLKSTESVAE---HDGPTEESLSFRN-----RAKTL----ETSQKFFCEFC 639

  Fly   855 ----QEQG-----GGGGGVAMLEFDSDCDSLNSSKV-----------SSTEGSQGGTILGPG--- 896
                |.:|     |..|.:.:.:..:.|.|.....|           ...|...||..|.|.
Zfish   640 KAKLQAEGIIQKTGETGRLILQQCTNACSSREGGAVDLIALPLPGNEEDEEIEDGGGKLQPPTHA 704

  Fly   897 --AIIPPGHPLKHSDS------------------------LTLL-----------AETINHELSG 924
              |..|||.....||.                        :||:           |:.::..|..
Zfish   705 AIAAPPPGFRDNSSDEDDPKKGRKGIKASTAVAQGQDEVPVTLIDNVTTRTVQDHAQELDDALVS 769

  Fly   925 ITQGLNAIPESAPVSTSAPPTPATPKRKPSLCSTSSPRPQRKLNG----FSQLLSDLQALGTDFS 985
            ..|.|.|:..|.........||.|    ..|...::..|:..|:.    .|..|:|:..:.:...
Zfish   770 TLQALEALAASEDYPHHQQQTPQT----TGLIVLAAITPESSLDSGHETNSSELTDVSEMVSAMK 830

  Fly   986 QSESDSESVASPAQSPT--TRRPQMMLL-----QAAGSSA-------GSVAPAKQQLSQRSSFGL 1036
            |.::.:..:|.......  :||...:.:     ||.|..|       ||..|....||:.....:
Zfish   831 QHQNQAYLLAHHINKERLFSRRDFPLTIPGCTTQAIGGGAFSMSQIRGSCPPKPVILSKTLPLKI 895

  Fly  1037 -------HSPDGTHFGAETKDYNLREYLQQLKEISNAASADTDVAARQLSEIYGFEVREDTFIET 1094
                   ||.....:|.                 |:.|:.:.|:      ||            |
Zfish   896 SPNKEISHSDKSAEWGK-----------------SHEANGEKDI------EI------------T 925

  Fly  1095 DTDLI-------------DLRAIPPPQTPDELDSLSLMNAAPPKGF--EGKAEE------LDSFL 1138
            :.||:             :|:|......|.....|.|.|...|...  ||..||      |::..
Zfish   926 EKDLVTECLEESKLQISEELKAPEHGSAPQVNTELLLANEEKPSTITSEGAQEEDSCAKTLETTS 990

  Fly  1139 QQIMVAPPTQKATPAK---------------ELTPEEIMSFIIP---------------PPPNLE 1173
            ..:.|..|..:.|.||               |.|.......::|               |...|:
Zfish   991 IALPVLLPVDRTTSAKICSTNRCQDAENASSETTKPSSSKGLLPTADLFCTCPIRPEPGPQVRLK 1055

  Fly  1174 QQQV--------VAPVETECLYSNSVQAKREFFQSVANGNNGT------VSHSPHIIEYATVERK 1224
            ..||        ::|.:.|.|::..:|..:|.....::.:..|      ..:||  :..|.||:|
Zfish  1056 DPQVQKLVVFHSLSPTDDERLHAQGLQLAKENTAKTSDASLVTPNTLPSTKYSP--VMSAKVEKK 1118

  Fly  1225 SKFSCCPTSKKEEQPGQEELQP-----PPRTPTTEQLS-------PPPARPPKSAE---LLQRYS 1274
            ........:.:.:.|  .|:|.     |.....|..||       .|.|...|.|.   ..||.:
Zfish  1119 EMSEAKAENSQSKSP--VEIQKVAKSLPVNVDPTHMLSCVEKGATIPGAEYKKQANNKGKSQRST 1181

  Fly  1275 PKKQVRIAASPVM------QPQERR---------------ELCPP-----QLPPRGS-------P 1306
            |....|...|...      :..|||               ||..|     :..|:||       |
Zfish  1182 PFLSFRNLISATFPARLRRETDERRAQLQKVRQYELEFLEELLKPKTSQGEFLPQGSSPVPSFTP 1246

  Fly  1307 TLDGSQSSPTNAVSGPKKPPLPPIACRPRPSNGVNSPN----------------SSSPGSAPPAH 1355
            .....::||...|.|..:.......|: |...|:..|:                |.:|.:.|.:.
Zfish  1247 CACQLRTSPVQKVPGISREQRRSCDCK-RMCRGMRLPDTAVGSATEQRGRERAISKTPPAIPKSP 1310

  Fly  1356 YSP----------------------------PIPA-----------TVRLPHLN----------- 1370
            ::|                            .||.           ::..||..
Zfish  1311 HTPQGELQKNQTLEIKTTRIRSTSLESREPRDIPTSCLPMCTTRTESIGAPHYKKLQRRYSIGEI 1375

  Fly  1371 QANGTLPL-------------------------LPKKPQQLH-----GEKLFIKNG--------- 1396
            :.||:.||                         ||...:.:|     .:|:|...|
Zfish  1376 ENNGSTPLYAEVKTTKAKSLEKEMERVRATGLRLPTPVEPVHTKDGDAKKIFYIQGEEILQESRE 1440

  Fly  1397 -----------------------------------------------HLIDGEALLAKTDVAMSG 1414
                                                           .::.|..|.::|...:|.
Zfish  1441 GTAEVLGLPSEDTEDREKCCSFCFCYRKCEAADESSEKDELSYSIPLQVLPGMHLDSRTMPVISK 1505

  Fly  1415 LLIKLDQVAAQCSVAQAAGGGTSIDEEKFQRARNELTEQTLALVTASKFLVASMSDMTLITLPEH 1479
            .|..||  |..|.      |...:.||:.|..|.:|  :....:.||...|.|:.|.| .:||:.
Zfish  1506 TLQVLD--AEDCC------GEEEVQEEEPQTQRIDL--RVCGNLEASLARVKSLQDKT-FSLPDG 1559

  Fly  1480 LTSC-------LTAIRRITELAQ--DMTRHTSAPL--QTRNIVLKVHDVASSFRELVGVEIGP-- 1531
            ..:.       |:.:|:.....|  ...|..||.|  ..:.:.::..:..:|.|.:..||..|
Zfish  1560 FLNAQLDANELLSILRQCANSPQIEGEPRIPSATLAEYKQELAVRFKEFRASCRRVASVEKSPSR 1624

  Fly  1532 -IGAGQLALQAEC-LANVLATLLRSLR 1556
             :.|...:.|..| |......|:|.:|
Zfish  1625 MLSAVTASFQVLCNLTQTFIQLVRGVR 1651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809
		WW	218..246	CDD:238122
		PDZ_signaling	257..333	CDD:238492	45/75 (60%)
		B41	396..617	CDD:214604	92/223 (41%)
		UBQ	396..477	CDD:294102	38/80 (48%)
		FERM_M	495..617	CDD:278785	46/124 (37%)
		PH-like	613..715	CDD:302622	27/136 (20%)
frmpd3	XP_021328436.1	PDZ_signaling	35..111	CDD:238492	45/75 (60%)
		B41	164..383	CDD:214604	92/223 (41%)
		PH-like	379..500	CDD:327399	25/124 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595606
Domainoid	1	1.000	129	1.000	Domainoid score	I5204
eggNOG	1	0.900	-	-		E1_KOG3552
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24527
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4089
SonicParanoid	1	1.000	-	-		X1331
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.730