DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42788 and magixa

DIOPT Version :9

Sequence 1:	NP_731964.2	Gene:	CG42788 / 41817	FlyBaseID:	FBgn0261859	Length:	1560	Species:	Drosophila melanogaster
Sequence 2:	XP_001337248.4	Gene:	magixa / 796857	ZFINID:	ZDB-GENE-060503-115	Length:	1309	Species:	Danio rerio

Alignment Length:	1422	Identity:	281/1422 - (19%)
Similarity:	427/1422 - (30%)	Gaps:	473/1422 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PLQNAANTTATSTGGATSAG-------GAGGAGGVGGVCGGVGATSNPKPLLLTRTSSPQLTTLP 72
            ||...:.....:.||....|       ..||...||.:...:|.|    |:|        ..||.
Zfish    21 PLGGGSGELGVAIGGGADYGEFPFVTAAPGGGATVGDIILEIGGT----PVL--------GLTLG 73

  Fly    73 TTNGSVVHATPTRSNGCPLTQSSGIPVTMATTATAMATATPDPSGCTEVE---------GTASTE 128
            ...|.:        |.||      .|:       .:.|.:|..:.|.::.         |:..::
Zfish    74 DVRGVL--------NSCP------HPI-------RIKTVSPGSTLCKDLRLYLSKCFTPGSMDSQ 117

  Fly   129 LSTGLANE-----TNCGTGIYGPLLGQSHGGVIAGMTENWPEIDGHLE-----AIQE--KLKPGW 181
            |...:...     ..|.|       .|...|.|:|:..|:..|:....     |:.|  |.|..:
Zfish   118 LQQVIRENLYLRAVPCTT-------RQPRDGEISGVDYNFVSIEEFFSLEESGALLESGKFKGNY 175

  Fly   182 -----SVHVG--------KEGRLYYCNHMTQSA-------------------------------- 201
                 .||:|        :|.|....|..|:|.
Zfish   176 YGTPRPVHIGPDSPPITYQEHRNLLRNFRTRSKSLSNLEKAVEEGDNSEEDSGLSAGSAGASSAP 240

  Fly   202 ------------------GWLPACEDWSKHEELSYGWERAIDSKGRSYYINHLNKTTTYEAP--- 245
                              |.|| .|:.::...|...||.|....|..|||||.:|||::..|
Zfish   241 PTTIVSPNQTWDLGGVRDGGLP-IENGARGGALPENWELAFSDTGEPYYINHNSKTTSWLDPRTQ 304

  Fly   246 --ECIRWDEHPPEPRQVQLQRNASL---------GFGF-VAGSERP---VIVRFVTEGGPSIGKL 295
              |.:...|.|....|....:..|:         |||| :.|..||   :.|..||.||||  .|
Zfish   305 GKEIVSKTELPAFTDQPSDLKGYSIHTRLLKGPRGFGFNIVGGSRPREFLQVYSVTPGGPS--AL 367

  Fly   296 QPGDQILAVNGEDVKDAPRDHVIQLVRACESQVNLLVCQPMAHCV----------------LPGR 344
            :..|.::.:|...|.......|::::::.          ||.|.|                .|
Zfish   368 KTADILVYINDSCVLGLSHKEVVEMLKSV----------PMGHSVDVVLRRGYPMLYNPDGCP-- 420

  Fly   345 KSTLLSAGKRAKLR----------------SRPSRVRFAESVCV--NGAPLFPPSAFSLGDICVP 391
            |::|.|........                .:|:.|....|:.:  |..|.....|........|
Zfish   421 KTSLASPSDTPNTNPAAPGSAQSQVQHPDGQQPAFVNLNRSMSLHNNFYPRMQKEALDANGNTAP 485

  Fly   392 ----PMAN---------VLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHV 443
                .|||         :..|.|.||...|.:..::.:..:|.|.:..:..|            :
Zfish   486 QPSYSMANGNGVGGIIGLGAVPLSNGPAPSERMSSSHSDTEVSSVVTRRASL------------I 538

  Fly   444 KSLKRNKL-------------------TLLD-PQESLARIAARPGAHKLRCLFRITFVPISAAEL 488
            :|...|.|                   |.|. ||..:...|..|||..:    :...:|.::..:
Zfish   539 RSYNNNSLPAPSHTNHSSKSSESDFSSTALPLPQPEVGPTAPPPGAPSI----QRPPMPQTSLAV 599

  Fly   489 AQRDLHALDYLYLQC----CNDVNQERFAP------------------ELQPELAL--------- 522
            |....|.      .|    |...|..|..|                  ||.| :||
Zfish   600 APPTEHP------PCGFNGCPANNPPRPLPGGLGSPGAPGGVGCGGGGELVP-VALGRSEGGGMG 657

  Fly   523 ----------RLAAL-HMHQHALANNFAPAKLTVKLVEREFGLERFVPVS--LFEGMKRKELRRL 574
                      :||.: .:......::..|....:|:...:.....|..|.  |.|..|:.|:..|
Zfish   658 FSVTAGGQGGQLAVVKRVWDRRQCHSLQPGDAIIKINGADVQSLSFAQVQRVLQEHTKQGEVVLL 722

  Fly   575 ISHFLKL------NA-----------EMTGSSSKVLTQLQAKLHYLDIIASLPSYGAKCFSTNQR 622
            :.....|      ||           ::|..||......|:.|........||:.   ..||:..
Zfish   723 VYRGGPLCSPGSPNAYKRPPPSLGTPDLTSPSSDGAVPSQSTLSPSSPCGDLPNL---VQSTSFL 784

  Fly   623 EGVERVLLVSPR------FGLSQISSARNSV-QPQPISAIEDFTHVVVNREDDVTCSVSIFMLGD 680
            :.|...|.:.||      .|.:|.|  |.:| .|..:|.    :||      |...::|     .
Zfish   785 DSVPVTLTLEPRDWLGVEDGPAQWS--RTAVSNPGAVSK----SHV------DTRAAIS-----S 832

  Fly   681 RAVKFIMEDRDGCEFSLVL------GGYYRLLTGNVLNILR--------EREPNDEDNAPGFLSQ 731
            ||:...:..|.|..|..|:      .|...|::...:.:.|        :.:|.|:..|....|.
Zfish   833 RAMDVELRRRPGEGFGFVIASQDVVNGTSSLVSHRFVTVRRGSPAARSGQIQPGDQLEAVEGRSV 897

  Fly   732 HTVLP----------AGWSYLLPFHTRAHSVNFLMAPPYHPLVQRGQLQQQSSIQAPSSLPYVMD 786
            .| ||          ||.:..|....|:|:.|.|  |.|.......:|::....:...|..|.:|
Zfish   898 VT-LPHRDLAQILRRAGNTLRLTIVPRSHTNNNL--PEYPDFDAESRLRKGHRAKQKDSQFYNVD 959

  Fly   787 LDLHSVMATELLEEAAKDSGLSDSSGSNYCEGRSHLGSHQLEAKNEQVLRRVQELQHLVQ----- 846
                       ||......|.|...||.|..|...||  .:|.......:::|....||:
Zfish   960 -----------LERGPTGFGFSLRGGSEYNMGLYVLG--LMEGGPASRSQKIQVSDQLVEINGDS 1011

  Fly   847 ----TSEQYLSEQEQGG---------GGGGVAMLEFDSDCDSLNSSKVSSTEGSQGGTILGPGAI 898
                |..|.:.:..:||         |.|.|.  ::|.:..:.:.|.|.|.|         |...
Zfish  1012 TVGMTHSQAVEQIRKGGARIHLVLKKGNGYVP--DYDHEAGAASPSSVFSEE---------PLVA 1065

  Fly   899 IPPGHPLKHS----DSLTLLAETINHEL------------SGITQGLNAIPESAPVSTSAPPTPA 947
            .....||:.|    ||        ..|.            ||..:|.:...|.  |||.......
Zfish  1066 AVDHTPLRSSRWVDDS--------GRERRERRGKGRTSRGSGADEGKHGWAED--VSTVGSSRST 1120

  Fly   948 TPKRKPSLCSTSSPRPQRKLNGFSQLLSDLQALGTDFSQSESDSESVASPAQSPTTRRPQMMLLQ 1012
            ..:::..:.|.|.|...|...| |:...|.:....|..|.|...|......:            |
Zfish  1121 RRRKEQQMRSRSLPGTLRGQEG-SRREEDEEEEKGDGKQGERKGEGERQRGR------------Q 1172

  Fly  1013 AAGSSAGSVAPAKQQLSQRSSFGLHSPDGTHFGAETKDYNLR-----------EYLQQLKEISNA 1066
            .:.|.......||...|||.: .|........|.|.:|.|..           .:|..|....:.
Zfish  1173 KSKSMGERRQKAKDVRSQREN-SLPVNGEKEGGREKRDKNRSSTTEVTQRAPFSFLMPLDNDDDG 1236

  Fly  1067 ASADTDVAARQLSEIYGFEVREDTFIETDTDLIDLRAIPPPQTPDELDSLSLMNAAP 1123
            :.|:   :|...||: ........|:.|...       |.|.:|.|....|.....|
Zfish  1237 SGAE---SAHSFSEV-SVSAASIAFLGTQWP-------PDPFSPSEASGSSTKAPGP 1282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809	9/88 (10%)
		WW	218..246	CDD:238122	13/32 (41%)
		PDZ_signaling	257..333	CDD:238492	21/88 (24%)
		B41	396..617	CDD:214604	53/301 (18%)
		UBQ	396..477	CDD:294102	19/100 (19%)
		FERM_M	495..617	CDD:278785	31/182 (17%)
		PH-like	613..715	CDD:302622	25/114 (22%)
magixa	XP_001337248.4	PDZ_signaling	24..89	CDD:238492	18/97 (19%)
		NK	112..>181	CDD:327404	14/75 (19%)
		WW	272..301	CDD:306827	13/28 (46%)
		PDZ	329..409	CDD:214570	23/91 (25%)
		PDZ_signaling	646..723	CDD:238492	12/76 (16%)
		PDZ_signaling	836..921	CDD:238492	17/85 (20%)
		PDZ_signaling	958..1036	CDD:238492	19/90 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010