DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42788 and magi2a

DIOPT Version :9

Sequence 1:	NP_731964.2	Gene:	CG42788 / 41817	FlyBaseID:	FBgn0261859	Length:	1560	Species:	Drosophila melanogaster
Sequence 2:	NP_001314782.1	Gene:	magi2a / 564112	ZFINID:	ZDB-GENE-050810-4	Length:	1503	Species:	Danio rerio

Alignment Length:	1586	Identity:	308/1586 - (19%)
Similarity:	502/1586 - (31%)	Gaps:	540/1586 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SNPKPLLLTRTSSPQLTTLPTTNG------SV-------VHATPTRSNGCPLTQSSGIPVTMATT 104
            :.|.||||...........||:.|      ||       :..........|:...:|:.:
Zfish   194 AEPSPLLLNVAEQLLPGATPTSQGKRRRNKSVSNMEKAGIEPPEEEEEERPVINGNGVAI----- 253

  Fly   105 ATAMATATPDPSGCTEVEGTASTELSTGLANETNCGTGIYGPLLGQSHGGVIAGMTENWPEIDGH 169
                   ||:.|...:....||.|::|...:||:...                      |:.|
Zfish   254 -------TPESSEHEDKSTDASGEMATTCPSETSTDA----------------------PKED-- 287

  Fly   170 LEAIQEKLKP-----------GWSVHVGKEGRLYYCNHMTQSAGWL---------PACEDWSKHE 214
            .|..:...||           .|.:...::|.:|:.:|.|::..||         |..|  .|..
Zfish   288 TEPPKSPPKPDENDELGPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEE--CKEN 350

  Fly   215 ELSYGWERAIDSKGRSYYINHLNKTTTYEAP--ECIRWDEHPP---------------------- 255
            ||.||||:..|....:||::|:|:.|.:|.|  |..|..:|..
Zfish   351 ELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRRLQHQQQMQSQGLSSLPLPAVYREKPLF 415

  Fly   256 --EPRQVQ-------LQRNASLGFGF-VAGSERP---VIVRFVTEGGPSI--GKLQPGDQILAVN 305
              :|.|::       ||: :::|||| :.|.:.|   :.|:.|...||:.  ||:..||.|:.:|
Zfish   416 TRDPTQLKGSFLSTPLQK-SNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMATGDVIVYIN 479

  Fly   306 GEDVKDAPRDHVIQLVRACE--SQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAE 368
            ...|.......|::|.::..  ..|.|::|:
Zfish   480 DVCVLGTTHADVVKLFQSVPIGQSVTLVLCR---------------------------------- 510

  Fly   369 SVCVNGAPLFPPSAFSLGDICVPPMANVLKVFLENGQTKSFKYDA----------------TTTV 417
                 |.|| |.......:..:.|:..:.:..|.||:.   .||:                ||.|
Zfish   511 -----GYPL-PYDPEDAANTLLSPLGLIDRPLLVNGRN---SYDSYMEYISRTARFVDPLQTTMV 566

  Fly   418 Q----DV---VSSLLDKLCLCC-----GELFSLVLEHVKSLKRNKLTLLDPQESLARIAARPGAH 470
            |    |.   ...|.|.:.:..     |||  |.:..||.......|:.|..          |..
Zfish   567 QPHPGDTHLDAGPLEDSVSMASSGAAGGEL--LTINMVKGADGFGFTIADSN----------GGQ 619

  Fly   471 KLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAPELQPELALRLAALHMHQHALA 535
            :::.:......|    .|.:.||..          ::||       ||.|.|.    |.....|.
Zfish   620 RVKQILEAQGCP----GLCEGDLIV----------EINQ-------QPALTLS----HTQVVELL 659

  Fly   536 NNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLISHFLKLNAEMTGSSSKVLTQLQAKL 600
            .. .|......||.:..|...|.|        .|..::::.|:..|::..|..|...|......|
Zfish   660 KE-CPIGTEATLVIQRGGTGHFSP--------WKTTKQVLEHWDPLSSPTTSLSVHALPHSAPYL 715

  Fly   601 HYLDIIASLPSYGAKCFSTNQREGVERVLLVSPRFGLSQISSARNSVQPQPISAIEDFTHVVVNR 665
            |:       ||                    .|.|.|:         :|.|....|....:..||
Zfish   716 HW-------PS--------------------GPEFDLA---------KPDPYDLYEKSRAIYENR 744

  Fly   666 EDDVTCSVSIFMLGDRAVKF------IMEDRDGCEFSLVLGG-----------YYRLLTGNVLNI 713
            :..:.   ...:..|.:.:|      :...:.|..|. :|||           ..::|.|.::
Zfish   745 QPGLP---RASLPADPSAEFQEVEVHLRRQKSGFGFR-ILGGEEPGQPVSPKAQEKILIGAII-- 803

  Fly   714 LREREPNDEDN--APG--FLSQHTVLPAG--WSYLLP-FHTRAH------SVNFLMAPPYHPLVQ 765
              |:.|.|:|.  .||  .:|...::.||  ..|::. .|..|.      :|...:.|...|..:
Zfish   804 --EKSPADKDGRLRPGDELISVDGIVVAGKPHRYVIDLMHGAARTGQVKLTVRRRVQPTGEPFPE 866

  Fly   766 RGQLQQQSSIQAPSSLPYVMDLDLHSVMATELLEEAAKDSGLSDSSGSNYCEGRSHLGSHQLEAK 830
            .|:....:...:|.|       |.:|.|...  ..|...:....::||          |....|.
Zfish   867 NGRSPGSTQHSSPRS-------DFNSRMFCN--NSAPSQNSAPSTTGS----------SPPDTAA 912

  Fly   831 NEQVLRRVQELQHLVQTSEQYLSEQEQGGGGGGVAMLEFDSDCDSLNSSKVSST----------- 884
            |:.           .|.::..:..:|..|.|..:        ..|||..:.::.
Zfish   913 NQN-----------AQPNDVSIQRKETEGFGFVI--------ISSLNRPETAAAAAVPHKIGRII 958

  Fly   885 EGSQ---------GGTILGPG--AIIPPGHPLKHSDSLTLLAETINHELSGITQGLNAIPESAPV 938
            |||.         |..||...  :|:    .:.|:|.:.|:.:      :|::..|..||:....
Zfish   959 EGSPADHCGKLKVGDRILAVNNQSIV----NMPHADIVKLIKD------AGLSVTLRIIPQEETN 1013

  Fly   939 ST--------SAPPTPATPKRKPSLCSTSSPRPQRKLNGFSQLLSDLQALGTDFSQSESDSESVA 995
            ||        .:|....:|..:|:..:.:...|....|...........:....|:::....:..
Zfish  1014 STPSAGSSEKQSPMAQPSPVCQPNTVNQTGAAPLANSNAQQNSAPQPSPIKQPISEAQPSLVTQN 1078

  Fly   996 SPAQSP---TTRRPQMMLLQ--AAGSSAGSVAPAKQQLSQ--RSSFG---------LHSPDGTHF 1044
            |||..|   |.:.||...:|  :..||..|...|:|.:..  |..|.         .|.|...:.
Zfish  1079 SPANHPSSVTQQNPQTQPVQTYSHDSSYRSEVKARQDVKPDIRQPFTDYRQPPVDYRHPPVADYR 1143

  Fly  1045 GAETKDYN------------------LREYLQQLKEISNAASADTDVAARQLS---EIYGFEVR- 1087
            ...|.||.                  |.:|         ....|.|....:|.   :.:||.:|
Zfish  1144 QPPTLDYRHPPLLDYRPLPADPRTFPLPDY---------RMPQDFDFFTVELEKGMKGFGFSIRG 1199

  Fly  1088 -----EDTFI--------------------------ETDTDLIDLRAIP---------------- 1105
                 .|.|:                          |:..|:...|||.
Zfish  1200 GREYKMDLFVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRG 1264

  Fly  1106 PPQTPDELDSLSLMNAAPPKGFEGKAEELDSFLQQIMVAPP--TQKATPAKELTPEEIMSFIIPP 1168
            ..|.|:..||.:..:|.|                   .|.|  ::.|.|...|:.....|.:.||
Zfish  1265 TGQVPEYADSPAPWDAHP-------------------TASPSLSEVAPPLDSLSNPSASSHVNPP 1310

  Fly  1169 --PPNLEQQQVVAPVETECLYSNSVQAKREFFQSVANGNNGTVSHSPHIIEYATVERKSKFSCCP 1231
              ||:....:.|.|        :|.|           |..|:.|.:   :|.|:|.::|..:...
Zfish  1311 TDPPHTSSLEAVGP--------DSCQ-----------GPRGSESRA---LEQASVGKRSALAGGV 1353

  Fly  1232 TSKKEEQPGQEELQPPPRTPTTEQLSPPPARPPKSAELLQRYSPKKQVRIAASPVMQPQERRELC 1296
            ....:::.|....:........:|.....|..|||.: ..|...|::.|..:|   .|..:|:..
Zfish  1354 GGGTKQREGSRTNRRSSGGKGQQQYLDEFAGEPKSHK-SSRAKSKERRRERSS---TPSRKRDSP 1414

  Fly  1297 PPQLPPR----GSPTLDGSQSS-----PTNAVSGPKKPPLPPIACRPRPSNGVNSPNSSSPGSAP 1352
            ...|...    |:..||||.|.     |..|:  ||:|....::....||:  ||..||:.|...
Zfish  1415 KTSLTDTSMNGGNGCLDGSNSQQGPLVPFKAL--PKEPEKGQMSQESNPSH--NSKISSAAGRKA 1475

  Fly  1353 PAHYSP-PIPATVRLPH-LNQANGTL 1376
            .....| .||.|.:||. |..|..|:
Zfish  1476 TVSPGPWKIPGTDKLPSTLRSATSTI 1501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809	7/36 (19%)
		WW	218..246	CDD:238122	12/29 (41%)
		PDZ_signaling	257..333	CDD:238492	25/90 (28%)
		B41	396..617	CDD:214604	49/248 (20%)
		UBQ	396..477	CDD:294102	21/108 (19%)
		FERM_M	495..617	CDD:278785	24/121 (20%)
		PH-like	613..715	CDD:302622	17/118 (14%)
magi2a	NP_001314782.1	PDZ_signaling	25..100	CDD:238492
		NK	122..286	CDD:302627	22/125 (18%)
		WW	307..337	CDD:238122	7/29 (24%)
		WW	352..381	CDD:278809	12/28 (43%)
		PDZ	431..511	CDD:214570	24/119 (20%)
		PDZ	595..676	CDD:214570	23/118 (19%)
		PDZ	762..856	CDD:214570	20/98 (20%)
		PDZ_signaling	920..1007	CDD:238492	18/104 (17%)
		PDZ_signaling	1182..1262	CDD:238492	11/79 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010