DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42788 and magi3a

DIOPT Version :9

Sequence 1:	NP_731964.2	Gene:	CG42788 / 41817	FlyBaseID:	FBgn0261859	Length:	1560	Species:	Drosophila melanogaster
Sequence 2:	NP_001352122.1	Gene:	magi3a / 561689	ZFINID:	ZDB-GENE-090312-48	Length:	1355	Species:	Danio rerio

Alignment Length:	1409	Identity:	264/1409 - (18%)
Similarity:	425/1409 - (30%)	Gaps:	544/1409 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 NW---PEIDGHLEAIQEKLKPGWSVHVGKEGRLYYCNHMTQSAGWL-----------PACEDWSK 212
            ||   |..|.     |:.|...|.:...:.|.:|:.:|.:::..||           ..|||
Zfish   276 NWNTMPRDDS-----QDPLPKNWEMAYTETGMVYFIDHNSKTTTWLDPRLAKKAKPPEKCED--- 332

  Fly   213 HEELSYGWERAIDSKGRSYYINHLNKTTTYEAP-----ECIRWDEHPP----------------- 255
             .||.||||:..|.:..:||::|:|:.|.:|.|     :.:..:..|.
Zfish   333 -GELPYGWEKIEDPQYGTYYVDHINQKTQFENPVQEAKKKLSQETSPTNQPTAAASAAVAAPAAA 396

  Fly   256 ------------EPRQVQ------LQRNASLGFGF-VAGSERP---VIVRFVTEGGPSI--GKLQ 296
                        :|.|:|      ..:.:..|||| :.|.:||   :.|:.|...||:.  .|:.
Zfish   397 PSGEVGLRGFTRDPSQLQGAILRTTLKKSPQGFGFTIIGGDRPDEFLQVKNVLRDGPAAHDNKIA 461

  Fly   297 PGDQILAVNGEDVKDAPRDHVIQLVRACESQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRP 361
            .||.|:.:||..|.......|:|:.::.  .||
Zfish   462 SGDVIVDINGACVLGKTHADVVQMFQSI--PVN-------------------------------- 492

  Fly   362 SRVRFAESVCVNGAPLFPPSAFS----LGDI--CVPPMANVLKVFLENGQTKSFKYDATTTVQDV 420
               ::.:.|...|.|| |....|    .|||  .:|.|         :||  ....|.|..:||:
Zfish   493 ---QYVDMVLCRGYPL-PEDTNSSEEGTGDIMTAMPGM---------DGQ--PIHLDGTAPLQDL 542

  Fly   421 VSSLLDKLCLCCGELFSLVLEHVKSLKRNKLTLLDPQESLARIAARPGAHKLRCLFRITFVPISA 485
            .....|      |.|.:..:.:.:..:..:.|||.|:.....:...||...    |.|...|
Zfish   543 HYMSAD------GRLPAAAMPNGRHPEAGESTLLQPELVSVPLVKGPGGFG----FAIADCP--- 594

  Fly   486 AELAQRDLHALDYLYLQCCNDVNQERFAPELQPELALRLAALHMHQHALANNFAPAKLTVKLVER 550
              |.|:....||   .|.|.
Zfish   595 --LGQKVKMILD---AQWCR--------------------------------------------- 609

  Fly   551 EFGLERFVPVSLFEGMKRKELRRLISHFLKLNAEMTGSSSKVLTQLQAKLHYLDIIASLPSYGAK 615
                      .|.:|...||:.|                ..|.|...|::  :||:..||
Zfish   610 ----------GLLKGDVIKEINR----------------QNVQTLSHAQV--VDILKDLP----- 641

  Fly   616 CFSTNQREGVERVLLVSPRFGLSQISSARNSVQPQPISAIEDFTHV--VVNREDDVTCSVSIFML 678
                   .|.|..:||. |.|           |..|:.:::..|..  :..::|.:|.|
Zfish   642 -------VGSEVNVLVL-RGG-----------QTSPVKSLKPITPAMPITQKQDIITTS------ 681

  Fly   679 GDRAVKFIMEDRDGCEFSLVLGGYYRLLTGNVLNILREREPNDEDNAPGFLSQHTVLPAGWSYLL 743
                  .|..|                            .|:..:.||              ..|
Zfish   682 ------SISTD----------------------------TPSPAEPAP--------------QSL 698

  Fly   744 PFHTRAHSVNFLMAPPY-----HPLVQRGQLQQQSSIQAPSSLPYVMDLDL-----------HSV 792
            ||            ||.     .|.:...:|..:|.....|......:||:           ..|
Zfish   699 PF------------PPQLIRSSSPKLDPTELYLKSKAMQDSKPINTKELDVFIKRNQETGFGFRV 751

  Fly   793 MATELLEE-----------AAKDSGLSDSSGSNYC------EGRSHLGSHQL---EAKNEQVLRR 837
            :..|..::           ||:..|...:.....|      :|:||....:|   .|:|.||:..
Zfish   752 LGGEGPDQPVYIGAIVPLGAAEKDGRLRAGDELICIDGVPVKGKSHKQVLELMTNAARNGQVMLT 816

  Fly   838 V---------QELQHLVQTSEQYLS--------------------------EQEQGGGGGGVAML 867
            |         :|...:...:.|.||                          :::...|.|.|.:.
Zfish   817 VRRKLTFQDREEDDGVYPPAPQALSLVNGSPKPSHVEVSGHSHPQPYDVTLQRKDNEGFGFVILT 881

  Fly   868 EFDSDCDSLNSSKV------SSTE-------GSQGGTILGPGAIIPPGHPLKHSDSLTLLAETIN 919
            ..:.....:...|:      |.|:       |.:...:.|...|     .|.|:|.:.|:.|..|
Zfish   882 SKNKPPPGVIPHKIGRIIEGSPTDRSGHLKVGDRISAVNGQSII-----DLSHNDIVQLIKEAGN 941

  Fly   920 HELSGITQGLNAIPESAP-----VSTSAPPT-PATPKRKPSL---CSTSSPRPQRKLNGFSQLLS 975
                .:|  |..:||...     :..|.||: .::.|:.|::   .....|..:...||..
Zfish   942 ----AVT--LTVVPEEGELWGKYLEHSGPPSGTSSAKQSPAIQHRAMGQQPASREDRNGVE---- 996

  Fly   976 DLQALGTDFSQSESDS----ESVASPAQSPTTRRPQMMLLQAAGSSAGSVAPAKQQLSQRSSFGL 1036
                     ::...||    |..|.|       :.:|..:..:|...|.. |.:.:..|| .||.
Zfish   997 ---------TEERKDSLGRVEYKALP-------QGEMGTVITSGIKQGCY-PVELERGQR-GFGF 1043

  Fly  1037 HSPDGTHFGAETKDYNLREYLQQLKEISNAASADTDVAARQLSEIYGFEVREDTFIETDTDLIDL 1101
            ....|       |:||:..::.:|.|...|..........|:.||.|         |....:...
Zfish  1044 SLRGG-------KEYNMGLFILRLAEDGPALKDGRIHVGDQIVEING---------EPTQGITHT 1092

  Fly  1102 RAIPPPQTPDELDSLSL---MNAAPPKGFEGKAEELDSFLQQIMVAP---------PTQKATPAK 1154
            |||...|.......|.|   :...|           |..:|.:|..|         .::.:|||.
Zfish  1093 RAIELIQAGGNKVLLLLRPGLGLVP-----------DHNMQDLMTGPSANSPRYSASSEPSTPAS 1146

  Fly  1155 ELTPEEIMSFIIPPPPNLEQQQVVAPVETECL-----------YSNSVQAKREFFQSVANGNNGT 1208
            .       |||...|       .|:|..||.|           |.::.|..|:...|:....|..
Zfish  1147 P-------SFISHSP-------AVSPPPTEELLNTSYGQLHQHYRDAKQQTRKIDPSMPRDTNDN 1197

  Fly  1209 VSHSPHIIEYATVERKSKFSCCPTSKKEEQPGQEELQPPPRTPTTEQLSPPPAR---PPKSAELL 1270
            ::          :.||........|.|:..||:.|    ||:.:..:......|   |.|:.:.|
Zfish  1198 LA----------IPRKLDGKERSRSPKKTYPGEHE----PRSSSPRKTKKDNIRQEMPQKAIDGL 1248

  Fly  1271 QRYSPKKQVRIAASPVMQPQERRELCPPQLPPRGSPTLDG-SQSSPTNAVSGPKKPPLPPIACRP 1334
            :..|.::.         |.::     |.|...|......| |:....|..:.|:||.........
Zfish  1249 RSSSGRRH---------QDED-----PAQKQDRAMEVSRGDSERYQRNKTAEPQKPHNESGTINR 1299

  Fly  1335 RPSNGVNSPN---------SSSP--GSAPPAHYSPPIPATVRLP 1367
            :...|::||.         |.:|  |..|.|..:|..|...::|
Zfish  1300 KDHRGLDSPRWDEDSKAAPSETPQNGGNPSAKKAPITPGPWKVP 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809	5/25 (20%)
		WW	218..246	CDD:238122	12/32 (38%)
		PDZ_signaling	257..333	CDD:238492	25/87 (29%)
		B41	396..617	CDD:214604	36/220 (16%)
		UBQ	396..477	CDD:294102	15/80 (19%)
		FERM_M	495..617	CDD:278785	16/121 (13%)
		PH-like	613..715	CDD:302622	14/103 (14%)
magi3a	NP_001352122.1	PDZ_signaling	32..98	CDD:238492
		NK	120..>194	CDD:327404
		WW	288..320	CDD:197736	7/31 (23%)
		WW	335..364	CDD:306827	12/28 (43%)
		PDZ	421..502	CDD:214570	23/117 (20%)
		PDZ	579..654	CDD:214570	28/172 (16%)
		PDZ_signaling	734..818	CDD:238492	16/83 (19%)
		PDZ_signaling	862..948	CDD:238492	17/96 (18%)
		PDZ_signaling	1032..1105	CDD:238492	20/89 (22%)
		MIP-T3	<1177..>1334	CDD:313469	36/184 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010