DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42788 and Magi2

DIOPT Version :9

Sequence 1:	NP_731964.2	Gene:	CG42788 / 41817	FlyBaseID:	FBgn0261859	Length:	1560	Species:	Drosophila melanogaster
Sequence 2:	XP_006535806.1	Gene:	Magi2 / 50791	MGIID:	1354953	Length:	1414	Species:	Mus musculus

Alignment Length:	1589	Identity:	291/1589 - (18%)
Similarity:	473/1589 - (29%)	Gaps:	658/1589 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NGSVVHATPTRSN--GCPLTQSSGIPVTMATTATAMATATPDPSG------------CTEVEGTA 125
            :|:::.:.....|  |.|...:...|: :..|...:..|||...|            ...:|...
Mouse   169 SGALLESGTYEDNYYGTPKPPAEPAPL-LNVTDQILPGATPSAEGKRKRNKSVTNMEKASIEPPE 232

  Fly   126 STELSTGLANETNCGTGIYGPLLGQSHGGVIAGMTENWPE------IDGHLEAIQEKL------K 178
            ..|....:.|    |.|:........|....||.:...|.      :....|.:::::      |
Mouse   233 EEEEERPVVN----GNGVVITPESSEHEDKSAGASGETPSQPYPAPVYSQPEELKDQMDDTKPTK 293

  Fly   179 P-----------GWSVHVGKEGRLYYCNHMTQSAGWL---------PACEDWSKHEELSYGWERA 223
            |           .|.:...::|.:|:.:|.|::..||         |..|  .|..||.||||:.
Mouse   294 PEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPPEE--CKENELPYGWEKI 356

  Fly   224 IDSKGRSYYINHLNKTTTYEAP--ECIR---------------------WDEHPPEPRQV-QLQ- 263
            .|....:||::|:|:.|.:|.|  |..|                     :.|.|...|.. ||:
Mouse   357 DDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGAKPLQAPGFREKPLFTRDASQLKG 421

  Fly   264 -------RNASLGFGF-VAGSERP---VIVRFVTEGGPSI--GKLQPGDQILAVNGEDVKDAPRD 315
                   :.:::|||| :.|.:.|   :.|:.|...||:.  ||::.||.|:.:|...|......
Mouse   422 TFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHA 486

  Fly   316 HVIQLVRACE--SQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPL- 377
            .|::|.::..  ..|||::|:                                       |.||
Mouse   487 DVVKLFQSVPIGQSVNLVLCR---------------------------------------GYPLP 512

  Fly   378 FPPS--AFSLGDICVPPMANVLK--VFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSL 438
            |.|.  |.|:    |||:|.:.:  ..:.||:..                            :..
Mouse   513 FDPEDPANSM----VPPLAIMERPPPVMVNGRHN----------------------------YET 545

  Fly   439 VLEHVKSLKRNKLTLLDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQC 503
            .||::....:                                   |..::..|..|:|
Mouse   546 YLEYISRTSQ-----------------------------------SVPDITDRPPHSL------- 568

  Fly   504 CNDVNQERFAPELQPELALRLAALHMHQHALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKR 568
                                        |::     ||         :..|:...|..:.:.
Mouse   569 ----------------------------HSM-----PA---------DGQLDGTYPPPVHDD--- 588

  Fly   569 KELRRLISHFLKLNAEMTGSSSKVLTQLQAKLHYLDIIASLPSYGAKCFSTNQREGVERVLLVSP 633
                         |..|..|.:     .||:|..|.|:.....:|.....:...:.|:::|.:..
Mouse   589 -------------NVSMASSGA-----TQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQG 635

  Fly   634 RFGLSQ----ISSARNSVQPQPISAIEDFTHVVVNREDDVTCSVSIFMLGDRAVKFIMEDRDGCE 694
            ..||.:    :...:.:||        :.:|..|           :.:|.|..|        |.|
Mouse   636 CPGLCEGDLIVEINQQNVQ--------NLSHTEV-----------VDILKDCPV--------GSE 673

  Fly   695 FSLVL--GGYY------RLLTGNVLNILREREPNDEDNAPGFLSQHTVLPAGWSYLLPFHTRAHS 751
            .||::  ||::      :.:.....|   :..|....:||       .:|..    |||....|.
Mouse   674 TSLIIHRGGFFSPWKTPKPMMDRWEN---QGSPQTSLSAP-------AVPQN----LPFPPALHR 724

  Fly   752 VNF---------LMAPPYHPLVQ-------RGQLQQQSSIQAPSSLPYVMDLDLH-----SVMAT 795
            .:|         ....||....:       |.|:..::|.:..||.|...:||:|     |....
Mouse   725 SSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGF 789

  Fly   796 ELL--EEAAKD--SGLSDSSGSNYCEGRSHLG--------------SHQL-------EAKNEQVL 835
            .:|  :|..:.  .|...:.||...:||.|.|              :|:.       .|:|.||.
Mouse   790 RILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVN 854

  Fly   836 RRVQE---------------------------------------------------LQHLVQTSE 849
            ..|:.                                                   ..|.:|||:
Mouse   855 LTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYSNSNHAAPSSNASPPEGFASHSLQTSD 919

  Fly   850 QYLSEQEQGGGGGGVAMLEFDSDCDSLNSSKVSSTEGSQGGTILGP---GAIIPPGHP------- 904
            ..:..:|..|.|..:        ..|||..:       .|.||..|   |.|| .|.|
Mouse   920 VVIHRKENEGFGFVI--------ISSLNRPE-------SGATITVPHKIGRII-DGSPADRCAKL 968

  Fly   905 ----------------LKHSDSLTLLAETINHELSGITQGLNAIPE-------SAPVSTS----- 941
                            :.|:|.:.|:.:      :|::..|..||:       |||.|..
Mouse   969 KVGDRILAVNGQSIINMPHADIVKLIKD------AGLSVTLRIIPQEELNSPTSAPSSEKQSPMA 1027

  Fly   942 ------------APPTPATPKRKPSLCSTSSPRPQRKLNGFSQLLSDLQALGTDFS-QSESDSES 993
                        |.|:||||  ...:...:.|:|             ||..|.:.| :||..:..
Mouse  1028 QQHSPLAQQSPLAQPSPATP--NSPVAQPAPPQP-------------LQLQGHENSYRSEVKARQ 1077

  Fly   994 VASP--AQSPTT--RRPQMMLLQAAGSSAGSVAPAKQQLSQRSSFGLHSPDGTHFGAETKDYNLR 1054
            ...|  .|.|.|  |:|.:...|..|.......|    |..|.    ||||       |:.|.|.
Mouse  1078 DVKPDIRQPPFTDYRQPPLDYRQPPGGDYSQPPP----LDYRQ----HSPD-------TRQYPLS 1127

  Fly  1055 EYLQQLKEISNAASADTDVAARQLSEIYGFEVR------EDTFI--------------------- 1092
            :|.|  .:..:..:.|.:..|:.    :||.:|      .|.::
Mouse  1128 DYRQ--PQDFDYFTVDMEKGAKG----FGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQI 1186

  Fly  1093 -----ETDTDLIDLRAIP----------------PPQTP--DELDSLSLMNAAPPKGFEGKAEEL 1134
                 |:..|:...|||.                ..|.|  ||..:.|...||.| |.......|
Mouse  1187 IEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPHAWSAAAAAAP-GLPEVGVSL 1250

  Fly  1135 DSFLQQIMVAPPTQKATPAKELTPEEIMSFIIPPPPNLEQQ-QVVAPVETECLYSNSVQAKREFF 1198
            :..|.....:.|...:.|:.::.|:        |..::::: .|..|.|    .|...|.|:..
Mouse  1251 EDILSPFSPSHPAPPSDPSHQIGPD--------PTWDIQREHDVRKPKE----LSAGGQKKQRL- 1302

  Fly  1199 QSVANGNNGTVSHSPHIIEYATVERKSKFSCCPTSKKEEQPGQEELQPPPRTPTTEQLSPPPA-- 1261
                 |.....|.||        :|.::      .:.||.||.:. :|....|.:|......|
Mouse  1303 -----GEQRERSASP--------QRSAR------PRLEEVPGGQG-RPEAGRPASEAADGKEALR 1347

  Fly  1262 --RPPKSAELLQRYSPKKQVRIAASPVMQPQERRELCPPQLPPRGSPTLDGSQSSPTNAVSGPKK 1324
              |....|...:....|..||..|.|..:|                  ..|..:.......||.|
Mouse  1348 GRREGLGAAGAREAEAKVGVRSGARPAARP------------------TGGGPARKATMAPGPWK 1394

  Fly  1325 PP----LPPIACRPRPSNGVNSPNSSSPG 1349
            .|    ||          |...|.:|:.|
Mouse  1395 VPGSDKLP----------GALQPGASAAG 1413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809	7/42 (17%)
		WW	218..246	CDD:238122	12/29 (41%)
		PDZ_signaling	257..333	CDD:238492	25/92 (27%)
		B41	396..617	CDD:214604	22/222 (10%)
		UBQ	396..477	CDD:294102	4/82 (5%)
		FERM_M	495..617	CDD:278785	15/121 (12%)
		PH-like	613..715	CDD:302622	19/113 (17%)
Magi2	XP_006535806.1	PDZ_signaling	22..96	CDD:238492
		NK	118..290	CDD:388413	20/125 (16%)
		WW	303..332	CDD:366073	7/28 (25%)
		WW	349..378	CDD:366073	12/28 (43%)
		PDZ	427..508	CDD:214570	23/119 (19%)
		PDZ	601..682	CDD:214570	19/107 (18%)
		MAGI_u5	681..755	CDD:374709	14/87 (16%)
		PDZ	774..860	CDD:214570	19/85 (22%)
		PDZ_signaling	919..1006	CDD:238492	20/108 (19%)
		PDZ_signaling	1138..1218	CDD:238492	11/83 (13%)
		MAGI_u1	1245..1285	CDD:374706	6/47 (13%)
		PHA03307	<1255..>1407	CDD:223039	39/212 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010