DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42788 and magi1b

DIOPT Version :9

Sequence 1:	NP_731964.2	Gene:	CG42788 / 41817	FlyBaseID:	FBgn0261859	Length:	1560	Species:	Drosophila melanogaster
Sequence 2:	XP_005155886.1	Gene:	magi1b / 474349	ZFINID:	ZDB-GENE-030131-5110	Length:	1625	Species:	Danio rerio

Alignment Length:	1684	Identity:	299/1684 - (17%)
Similarity:	480/1684 - (28%)	Gaps:	688/1684 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VGGVCGGVGATSNPKPLLLTRTSSPQLTT-------LPTTNGSVVHATPTRSNGCPLTQSSGIPV 99
            :|...|....|  |||.:  :..|.::.|       ||.:..|    ||.|:......|::||..
Zfish   174 IGSYEGNYYGT--PKPPI--KPPSGKVITGDALQDSLPGSQPS----TPRRTKSYNEMQNAGIVP 230

  Fly   100 T----------MATTATAMATATPDPSGCTEVEGTASTELSTGLANETNCGTGIYGPLLGQSHGG 154
            |          |.::.|..::   :|.....|...|..:|.....|.|:..|
Zfish   231 TETEDDDEVPEMNSSFTGDSS---EPDDHPSVRPFARDQLQPYGLNNTSAST------------- 279

  Fly   155 VIAGMTENWPEIDGHLEAIQEK-----LKPGWSVHVGKEGRLYYCNHMTQSAGWL-PAC------ 207
                 ||:......|.....|:     |...|.:...:.|.:|:.:|.|::..|: |.|
Zfish   280 -----TESSQNTHTHPAYPTEEDPLGPLPENWEMAYTENGEVYFIDHNTKTTSWIDPRCLDKPQK 339

  Fly   208 -------------EDWSKHEELSYGWERAIDSKGRSYYINHLNKTTTYEAP--ECIR-------- 249
                         |:.....||..|||:..|.....||::|:|:.|.||.|  |..|
Zfish   340 PLEECEDDEGVHTEELDNELELPTGWEKIDDPVYGVYYVDHINRKTQYENPILEAKRKKQLEQSQ 404

  Fly   250 ----------W-DEH-----------------------PPEPRQVQLQR---------------- 264
                      | |||                       ||.|.|:..:|
Zfish   405 PAEGERFIQEWIDEHSSGAPLASYAANHQETYRDPGTGPPLPTQLGAKRGKPFFTRNPAELKGTF 469

  Fly   265 -NASL-----GFGF-VAGSERP---VIVRFVTEGGPSI--GKLQPGDQILAVNGEDVKDAPRDHV 317
             |..|     |||| |.|.:.|   :.::.:...||:.  ||::.||.|::||...|.......|
Zfish   470 INTKLKKSRRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGYTHAQV 534

  Fly   318 IQLVRACE--SQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLF-P 379
            :::.::..  |.|:|.:|:.......|...:|.|.... |.|...|        :.|||...: .
Zfish   535 VKIFQSIPIGSMVDLELCRGYPLPFDPDDPNTSLVTSV-AILDKEP--------IIVNGKESYDS 590

  Fly   380 PSAF---------SLGDICVPPMANVLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGEL 435
            ||:.         ||.....||..:.....:.:..:..:..|..|....:.:.         .||
Zfish   591 PSSHGSETTAGGSSLNGSSDPPRPHSPSAEVASNGSHGYPSDVVTLASSIATQ---------PEL 646

  Fly   436 FSLVLEHVKSLKRNKLTLLDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLY 500
            .::.:|  |..|....|:.|                            |.:...||....:||
Zfish   647 ITVHME--KGDKGFGFTIAD----------------------------SPSGGGQRVKQIVDY-- 679

  Fly   501 LQCCNDVNQERFAPELQPELALRLAALHMHQHA----------------LANNFAPAKLTVKLVE 549
             ..|..:.:.....|:.......|.    |...                :....||||.:.||
Zfish   680 -PRCRGLREGDIIMEVNKRNVQNLT----HNQVVDLLSKCPKGSEVTMLVQRGVAPAKKSPKL-- 737

  Fly   550 REFGLERFVPVSLFEGMKRKELRRLISHFLKLNAEMTGSSSKVL---TQLQAKLHYLDIIASLPS 611
                          :.::||:.:....|.:        ||.:.:   :.|.|....|:..|:.|.
Zfish   738 --------------QQLERKDSQGSSQHSV--------SSQRSIHTDSPLHASQALLNESAAPPP 780

  Fly   612 YGAKCFSTNQREGVERVLLVSPRFGLSQISSARNSVQPQPI-----------SAIEDFTHVVVNR 665
            ......|..|...|:..|                ..:|.|.           |.:.|:      :
Zfish   781 PSQPLPSLPQDPPVDGTL----------------QKKPDPFKIWAQSRSMYESRLPDY------Q 823

  Fly   666 EDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVLGGYYRLLTGNVLNILREREPNDEDNAPGFLS 730
            |.|:               |:.....|..|        |:|.||        ||.:    |.::.
Zfish   824 EQDI---------------FLWRKDTGFGF--------RILGGN--------EPGE----PIYIG 853

  Fly   731 QHTVLPAGWSYLLPFHTRAHSVNFLMAPPYHPLVQRGQLQQQSSIQAPSSLPYVMDLDLHSV--- 792
            .                               :|:.|...:...:::...|   :.:|..:|
Zfish   854 H-------------------------------IVKYGAADEDGRLRSGDEL---ICVDGTAVVGK 884

  Fly   793 ---MATELLEEAAKDS------------GLSDSSGS-NYCEGRSHLGSHQLEAKNEQVLRRVQEL 841
               :..:|:::|||..            ||:...|. ......||..|.|..:..|:
Zfish   885 SHQLVVQLMQQAAKQGHVNLTVRRKTGYGLAKVDGEMPPSPASSHHSSTQAPSLTEE-------- 941

  Fly   842 QHLVQTSEQYLSEQEQG---------GGGGGV-------AMLEFD-----SDCDSLNSSKVSSTE 885
            :...|.|:..|:....|         |||||.       |:|.:|     .:.:......|||..
Zfish   942 KRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSNNTVIPNAILPYDVEIQRGENEGFGFVIVSSVS 1006

  Fly   886 GSQGGTILGPGAIIPPGHPL--------------------------------KHSDSLTLLAETI 918
            ..:.||.....|.:...|.:                                .|||.:.|:.|
Zfish  1007 RPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE-- 1069

  Fly   919 NHELSGITQGLNAIP----ESAPVSTSAP-----PTPATPKRKPSLCSTSSPRPQRKLNGFSQLL 974
                :|.|..|..||    .:|.:.|:|.     .|..||:::      ::|.|:..
Zfish  1070 ----AGNTVTLRIIPGDESSNASLLTNAEKIATITTTHTPQQQ------AAPEPRNN-------- 1116

  Fly   975 SDLQALGTDFSQSESDSESVASPAQSPTTRRPQMMLLQAAGSSAGSVAPAKQQLSQRS----SFG 1035
                      ::.:.:|....:|...|                    .||..|.|.:.    |..
Zfish  1117 ----------TKPKQESFEFKAPQAPP--------------------PPAPTQSSNQDAEFYSVD 1151

  Fly  1036 LHSPDGTHFGAET---KDYNLREYLQQLKEISNAASADTDVAARQLSEIYGFEVREDTFIETDTD 1097
            |.. |...||...   ::||:..|:.:|.|...|..........::.||.|         |:...
Zfish  1152 LER-DNKGFGFSLRGGREYNMDLYVLRLAEDGAAVRNGKMRVGDEILEING---------ESTKG 1206

  Fly  1098 LIDLRAIPPPQTPDELDSLSLMNAAPPKGFEGKAEELDSF------------LQQIMVAPPTQKA 1150
            :...|||...:.......|.|...      :|...|.|..            :.::..|||..:.
Zfish  1207 MKHARAIELIKNGGRKVHLVLRRG------DGSVPEYDGINDGNGLGAGAQTVSEVNSAPPESRP 1265

  Fly  1151 TPAKELTPEEIMSFIIPPPPNLEQQQVVAPVETECLYSNSVQAKREFFQSVANGNNGTVSHSPHI 1215
            .|..|      .|:    ||:|.:..           .|..:..||..|. .:|:.....|:.|
Zfish  1266 HPPSE------SSY----PPDLHKSS-----------RNDNKRTRESGQR-EHGHRSNHRHNNH- 1307

  Fly  1216 IEYATVERKSKF----SCCPTSKKEEQPGQEE--------------------------------- 1243
             .:.:.|:||:.    ....|||...:.|.::
Zfish  1308 -RHRSPEKKSRSKGHGKDSGTSKSHRKKGDKKKSSTDDSHHHHHHHSNSRNQYHHHRQRHRSPER 1371

  Fly  1244 ----------------------------------------------------------------- 1243

Zfish  1372 RRTRSAGDTLDSRHTQRNGRSPDRRHHRHSSPRRHSSPHRSPHRSGYRRSSPYRNRSPYRSPQRS 1436

  Fly  1244 -LQPPPRTPTTEQL---------SPPPARPPKSAE---LLQRYSPKKQVRIAASPVMQ--PQERR 1293
             .|.|.|.||.::.         .|||.:||..:|   ||.|.|       ....||:  |..||
Zfish  1437 RYQSPSRRPTDKEFDRGIDVTLKEPPPPKPPSRSESIPLLDRLS-------LEDTVMREPPSYRR 1494

  Fly  1294 ELCPPQLPPRGSPTLDGSQSSPTNAVSGPKKPPLPPIACRPRPSNGVNSPNSSSPGSAP 1352
            :|.|.:...|.|..|.|:....|.           |....|...:...:.||...|.:|
Zfish  1495 DLSPMERAYRESTLLRGASRDGTF-----------PRVRTPESDSAFRNYNSLLRGRSP 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809	6/25 (24%)
		WW	218..246	CDD:238122	12/29 (41%)
		PDZ_signaling	257..333	CDD:238492	26/105 (25%)
		B41	396..617	CDD:214604	34/239 (14%)
		UBQ	396..477	CDD:294102	9/80 (11%)
		FERM_M	495..617	CDD:278785	22/140 (16%)
		PH-like	613..715	CDD:302622	17/112 (15%)
magi1b	XP_005155886.1	PDZ_signaling	17..95	CDD:238492
		NK	117..>242	CDD:302627	18/75 (24%)
		WW	301..332	CDD:197736	7/30 (23%)
		WW	361..390	CDD:278809	12/28 (43%)
		PDZ	473..554	CDD:214570	23/80 (29%)
		PDZ	645..727	CDD:214570	16/118 (14%)
		MAGI_u5	726..818	CDD:293271	22/131 (17%)
		PDZ_signaling	832..907	CDD:238492	18/128 (14%)
		PDZ_signaling	984..1079	CDD:238492	16/100 (16%)
		PDZ_signaling	1150..1228	CDD:238492	18/87 (21%)
		DUF1777	1353..>1456	CDD:285811	5/102 (5%)
		PRP38_assoc	1369..1453	CDD:289628	5/83 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010