Protein Alignment CG42788 and frmpd4

DIOPT Version :10

• Sequence 1: NP_731964.2
• Gene: CG42788 / 41817
• FlyBaseID: FBgn0261859
• Length: 1560
• Species: Drosophila melanogaster
• Sequence 2: XP_073769425.1
• Gene: frmpd4 / 403129
• ZFINID: ZDB-GENE-121004-1
• Length: 1233
• Species: Danio rerio
• Alignment Length: 1181
• Identity: 332/1181 - (28%)
• Similarity: 511/1181 - (43%)
• Gaps: 308/1181 - (26%)

  Fly   156 IAGMTENWPEIDGHLEAIQEKLKPGWSVHVGKE---GRLYYCNHMTQS--------AGWLPACED 209
            :||.|.||.:               ||....:.   ..:|...|.|:|        .||.||
Zfish    12 LAGQTLNWAD---------------WSCQANRSSFTSFIYALCHRTKSPCCPPPAPGGWAPA--- 58

  Fly   210 WSKHEELSYGWERAIDSKGRSYYINHLNKTTTYEAPECIRWDEH---PPEPRQVQLQRNASLGFG 271
                :....|||.::..:.|..|:|||:::::.|.   :|.|..   ||.||:|:::|:..||||
Zfish    59 ----QGPPNGWEMSLSREARDCYVNHLSQSSSLEE---VRVDVEKFVPPAPRKVEMRRDPVLGFG 116

  Fly   272 FVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHVIQLVRACESQVNLLVCQPM 336
            ||||||:||:||.||.||||.|||.|||:|:.:|.|.|..|||:.||.|||:|:..:.|.|.||
Zfish   117 FVAGSEKPVVVRSVTPGGPSEGKLIPGDEIVMINEEPVSSAPRERVIDLVRSCKESIILTVVQP- 180

  Fly   337 AHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLFPPSAFSLGDICVPPMANVLKVFL 401
                .|..||..:||.|:|||:|.|.:|||||.|.:||.   .|.  |:.|..:..|.|||||:|
Zfish   181 ----YPSPKSAFISAAKKAKLKSNPVKVRFAEEVIINGQ---VPE--SVKDNSLLFMPNVLKVYL 236

  Fly   402 ENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRNKLTLLDPQESLARIAAR 466
            |||||||||:|..|:::||:.:|.:||.:...|.|||:|||.......||.||..||.|.::..|
Zfish   237 ENGQTKSFKFDCNTSIKDVILTLQEKLSIKSIEHFSLMLEHKVEGSATKLMLLHEQEMLTQVTQR 301

  Fly   467 PGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAPELQPELALRLAALHMHQ 531
            ||:||::|.|||:|:|....:|.:||..|.||||:|.|.||.||||..||:.:.|||||||.|:.
Zfish   302 PGSHKMKCYFRISFLPKDPVDLLRRDAAAFDYLYVQSCKDVVQERFGSELKYDTALRLAALQMYI 366

  Fly   532 HALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLISHFLKLNAEMTGSSSKVLTQL 596
            ..|:.... .|:::|.:|:|:||.:|:|.::...||.|.:::.::|.||.|..:.....| ||.|
Zfish   367 LTLSTKHT-QKVSLKYIEKEWGLAQFLPPAVLSSMKEKNIKKALTHILKTNQNLVPPGKK-LTAL 429

  Fly   597 QAKLHYLDIIASLPSYGAKCFSTNQREG---VERVLLVSPRFGLSQISSARNSVQPQPISAIEDF 658
            |||:|||..::.|..||.:.|.:...:|   .|..|||.||:|:|.:.:.:.::    ::.:.||
Zfish   430 QAKVHYLKYLSDLRLYGGRVFKSTLVQGEKHTEVTLLVGPRYGISHVINTKTNL----VALLADF 490

  Fly   659 THVVVNR-----EDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVLGGYYRLLTG---NVLNILR 715
            :|  |||     ||:....|.:.:|..:.:..|||..|....:.:..||||||..   ::.|:..
Zfish   491 SH--VNRIEMYTEDERNVRVELHVLDVKPITLIMESSDAMNLACLTAGYYRLLVDSRRSIFNMAN 553

  Fly   716 EREPNDEDNAPGFLSQHTVLPAGWSYLLPFHTRAHSVNFLMAPPYHPLVQRGQLQQQSSIQAPSS 780
            .......|..    .:|......|:|     ......|    .|:......|:.:...|   ||.
Zfish   554 NSNTAGHDTR----IKHNYQAIDWNY-----GTCGGCN----EPHPEYAVCGRRECDIS---PSE 602

  Fly   781 LPYVMDLDLHSVMATELLEEAAKDSGLSDSSGSNYCEGRSH-----------LGSHQLEAKNEQV 834
            :.     ..|.:...|..|..::.|.:......|..:|:..           .|...|::.|.|.
Zfish   603 IH-----QAHHMHGDEKAERQSRGSHMHAQPYFNIPKGKPQESPRSAKVSFIFGDPPLDSVNPQN 662

  Fly   835 L---RRVQELQHLVQTSEQYLSEQEQGGGGGGVAMLEFDSDCDSLNSSKVSSTEGSQGGTILGPG 896
            |   |.::::..::: ..:||..|::              |...|.:|  ...:|.|.||.:..|
Zfish   663 LGYHRLMEDIPEVLE-EHRYLYAQQK--------------DYKPLEAS--LEVDGFQYGTHMVYG 710

  Fly   897 AIIPPGHPLKHSDSLTLLAETINHELSGITQGLNAIPESAPVSTSAPPTPATPKRKPSLCSTSSP 961
                                  :.::.|.|:|:.
Zfish   711 ----------------------DAKIFGTTEGIE------------------------------- 722

  Fly   962 RPQRKLNGFSQLLSDL-QALGTDFSQSESDSESVASPAQSPTTRRPQMMLLQAAGSSAGSVAPAK 1025
                     ..||.|: .|..||.::.:.|.          :.....||::......|.|:
Zfish   723 ---------EPLLHDICYAETTDDAEEDDDI----------SCEEDMMMMMGEMKDKANSL---- 764

  Fly  1026 QQLSQRSSFGLHSPDGTHFGAETKDYNLREYLQQLKEISNAASADTDVAARQLSEIYGFEVREDT 1090
                                                 :|.:.|:|
Zfish   765 -------------------------------------LSLSESSD-------------------- 772

  Fly  1091 FIETDTDLIDLRAIPPP-------QTPDELDSLSLMNAAPPKGFEGKAEELD------------- 1135
                  |:|||.::|||       .:.|.|:||:|..||||.||...::|.|
Zfish   773 ------DIIDLTSLPPPPEGDYEEDSDDLLESLNLAIAAPPPGFRDSSDEDDHHDRKMSKNDIPV 831

  Fly  1136 SFLQQIMVAPPTQKATPAKELTPEEIMSFIIPPPPNLEQQQVVAPVETECL----YSNSVQAKRE 1196
            |.:..:    |||.|..::|:..:.::|       .|:..:.:|..|.:..    .|:.|:..|.
Zfish   832 SLIDSV----PTQVAGGSEEVFNDAVVS-------TLQALEALAASEDQSHPQSDNSSGVEISRS 885

  Fly  1197 FF--QSVANGNNGTVSHSPHIIEYATVERKSKFSC---CPTSKKEEQPGQEELQPPPRTPTTEQL 1256
            |.  .|..:||....|......|.|..::.|:.|.   ..|::..:...:||        |..:|
Zfish   886 FSPESSSDSGNETNSSEMTESSELAAAQKLSENSLKMFVATAEGYQTLAEEE--------TEFRL 942

  Fly  1257 SPPPARPPKSA 1267
            :|....|..||
Zfish   943 APSLDDPQSSA 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:459800	6/36 (17%)
		WW	218..246	CDD:238122	9/27 (33%)
		PDZ_FRMPD1_3_4-like	259..333	CDD:467250	42/73 (58%)
		FERM_F1_FRMPD1_like	393..482	CDD:340608	47/88 (53%)
		B41	396..617	CDD:214604	101/220 (46%)
		PH-like	613..715	CDD:473070	32/112 (29%)
		PHA03247	<1105..1377	CDD:223021	47/192 (24%)
frmpd4	XP_073769425.1	None