Protein Alignment CG42788 and Frmpd4

DIOPT Version :10

• Sequence 1: NP_731964.2
• Gene: CG42788 / 41817
• FlyBaseID: FBgn0261859
• Length: 1560
• Species: Drosophila melanogaster
• Sequence 2: XP_017457487.1
• Gene: Frmpd4 / 302656
• RGDID: 1566031
• Length: 1759
• Species: Rattus norvegicus
• Alignment Length: 1499
• Identity: 386/1499 - (25%)
• Similarity: 598/1499 - (39%)
• Gaps: 424/1499 - (28%)

  Fly   195 NHMTQSAGWLPACEDWSKHEELSYGWERAIDSKGRSYYINHLNKTTTYEAPECIRWDE---HPPE 256
            :|.|:|:||.|....|..::...||||...:..||.|:|||:.:...::.|   |:|.   .||.
  Rat    14 SHRTKSSGWPPPSGTWGLNQVPPYGWEMMTNRDGRDYFINHMTQAIPFDDP---RFDSCQIIPPA 75

  Fly   257 PRQVQLQRNASLGFGFVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHVIQLV 321
            ||:|:::|:..||||||||||:||:||.||.||||.|||.|||||:.:|.|.|..|||:.||.||
  Rat    76 PRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLV 140

  Fly   322 RACESQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLFPPSAFSLG 386
            |:|:..:...|.||     .|..||..:||.|:|:|:|.|.:|||:|.|.:||     ..:.::.
  Rat   141 RSCKESILFTVIQP-----YPSPKSAFISAAKKARLKSNPVKVRFSEEVIING-----QVSETVK 195

  Fly   387 DICVPPMANVLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRNKL 451
            |..:..|.|||||:|||||||||::|.:|:::||:.:|.:||.:...|.|||:||........||
  Rat   196 DNSLLFMPNVLKVYLENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKL 260

  Fly   452 TLLDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAPEL 516
            .||..||:|.::..||.:||:||||||:|||....:|.:||..|.:|||:|.||||.||||.|||
  Rat   261 LLLHEQETLTQVTQRPSSHKMRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPEL 325

  Fly   517 QPELALRLAALHMHQHALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLISHFLKL 581
            :.::|||||||.|: .|........|:::|.:|:|:|||.|:|.::.:.||.|.:::.:||.:|.
  Rat   326 KYDIALRLAALQMY-IATVTTKQTQKISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKA 389

  Fly   582 NAEMTGSSSKVLTQLQAKLHYLDIIASLPSYGAKCFSTNQREGVER---VLLVSPRFGLSQISSA 643
            |..:.....| |:.||||:|||..::.|..||.:.|.....:..:|   .|||.||:|:|.:.:.
  Rat   390 NQNLVPPGKK-LSALQAKVHYLKFLSDLRLYGGRVFKATLVQAEKRSEVTLLVGPRYGISHVINT 453

  Fly   644 RNSVQPQPISAIEDFTHVVVNR-----EDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVLGGYY 703
            :.::    ::.:.||:|  |||     |::....|.:.:|..:.:..:||..|....:.:..|||
  Rat   454 KTNL----VALLADFSH--VNRIEMFTEEESLVRVELHVLDVKPITLLMESSDAMNLACLTAGYY 512

  Fly   704 RLLTG---NVLNILREREPNDEDNAPGFLSQHTVLPAGW-------------------SYLLPFH 746
            |||..   ::.|:..::....:|.......:|.:|...|                   :|:....
  Rat   513 RLLVDSRRSIFNMANKKNAGTQDTGTENKGKHNLLGPDWNCMPQMTTFIGEGEQEAQITYIDSKQ 577

  Fly   747 TRAHSVNFLMAPPYH----------------PLVQRG---------QLQQQS--SIQAPSSLPYV 784
            ......:..:.|..|                ||.|.|         .|.|:|  ::..|.:|...
  Rat   578 KAVEMTDSTLCPKEHRHLYIDNTYSSDELSQPLTQPGDAPCEADYRSLAQRSLLTLSGPDTLKKA 642

  Fly   785 MDLDLHSVMATELLEEAAKDSGLSDSSGSNYCEGRSHLGSHQLEAKNEQVLRRVQELQHLVQTSE 849
            .: .......:.:..:.|.|.|:|..:          ||..::..:|.::|.:.:.|
  Rat   643 QE-SPRGAKVSFIFGDLALDDGMSPPT----------LGYERMLDENPEMLEKQRNL-------- 688

  Fly   850 QYLSEQEQGGGGGGVAMLEFDSDCDSL---------NSSKVSSTEGSQGGTILGPGAIIPPGHPL 905
             |:|      ....:..|:...|.||:         |...|.:.|..:|           ...||
  Rat   689 -YIS------SANDMKNLDLTPDTDSIQFVANSVYANIGDVKNFEAPEG-----------IEEPL 735

  Fly   906 KH-------------SDSLT----LLAETINH----ELSGITQGLNAIPESAPVSTSAPPTPATP 949
            .|             .|.::    |:...||.    :|||.:..:..:       |:.||.....
  Rat   736 LHDICYAENTDDAEDEDEVSCEEDLVVSEINQPAILDLSGSSDDIIDL-------TTLPPPEGDD 793

  Fly   950 KRKPSL-----CSTSSPRPQRKLNGF--SQLLSDLQALGTDFSQSESDSESVASPAQSPTTRRPQ 1007
            .....|     .:.::|.|     ||  |....|.|:..|.|.:::....|:.: .:.|.:
  Rat   794 NEDDFLLRSLNMAIAAPPP-----GFRDSSDEEDTQSQATSFHENKEQGSSLQN-EEIPVS---- 848

  Fly  1008 MMLLQAAGSSAG------------------SVAPAKQQLSQRSSFGL---HSPD-GTHFGAETKD 1050
              |:.|..:||.                  .....:||.|:.|...:   :||: .:..|.||..
  Rat   849 --LIDAVPTSAEGKCEKGLDPTVVSTLEALEALSEEQQKSENSGVAILRAYSPESSSDSGNETNS 911

  Fly  1051 YNLREYLQQLKEISNAASADTDVAARQLSEIYGFEVREDTFIETDTDLIDLRAIPPPQTPDELDS 1115
            ..:.|.    .|::.|......::...|:...|:.    ...|..|:      .|..:||    |
  Rat   912 SEMTEG----SELAAAQKQSESLSRMFLATHEGYH----PLAEEQTE------FPTSKTP----S 958

  Fly  1116 LSLMNAAPPKGFEGKAEELDSFLQQIMVAPPTQKATPAKELTPEEIMSFIIPPPPNLEQQQV--- 1177
            :.|    |||...|.|....:.|      ||  |..|:|::...:.|..   .|..:|.:.|
  Rat   959 VGL----PPKSSHGLAARPATDL------PP--KVVPSKQILHSDHMEM---EPETMETKSVTDY 1008

  Fly  1178 --------------------VAPVETECLYSNSVQAKREFFQSVA------NGNNGTVS--HSPH 1214
                                :|..|.:|..|.:|..|::....:|      .|..||||  .:||
  Rat  1009 FSKLHMGSVAYSCTSKRKSKLAEGEGKCPLSGNVPGKKQQGTKIAETEEDTKGKVGTVSSRDNPH 1073

  Fly  1215 -------------------------IIEYATVERKS--KFSCCPTSKKEEQPGQE---------- 1242
                                     ::|.:.||..:  .|...|.....|..|:|
  Rat  1074 LSTFNLERTAFRKDSQRWYVASDGGVVEKSGVEAPAMKAFPRGPGLGNREAEGKEDGTMEGEADD 1138

  Fly  1243 ---------------------ELQPPPRT--PTTEQLSPPPARPPKSAELLQRYSPKKQVRI--- 1281
                                 :|..|..|  ||.:..:..|......|.|...:..|:...:
  Rat  1139 ASGLGQGERFLSDMACVASAKDLDNPEDTDSPTCDHATKLPEAEDNVARLCDYHLAKRMSSLQSE 1203

  Fly  1282 -------------------------AASPVMQPQERRELCP-------PQLPPRGSPTLDGSQSS 1314
                                     .|:||..|     |||       |....:|     ||..|
  Rat  1204 GHFSLQSSQGSSVDTGCGPGSSSSACATPVESP-----LCPSMGKHLIPDASGKG-----GSYIS 1258

  Fly  1315 PTNAVSG------------PKKPPLPPIACRPRPSNGVNS------------------------- 1342
            |...|:|            |:...:.|....|.....:|:
  Rat  1259 PEERVAGHPNHGATFKELHPQTEGMCPRMTVPALHTAINADPLFGTLRDGCHRLPKIKETTALTE 1323

  Fly  1343 PNSSSPGSAPPAHYSPPIPATVRLP---HL-----------------NQANGTLPLLPKKPQQLH 1387
            |.....|..|.|....|....:.||   ||                 |||.|  ..:..:|..|.
  Rat  1324 PGKERQGGMPSAWSPHPEADPILLPSNIHLESKVPSPNQDPNDFSQGNQAFG--EAVSWRPADLR 1386

  Fly  1388 GEKL 1391
            |..|
  Rat  1387 GGSL 1390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:459800	3/7 (43%)
		WW	218..246	CDD:238122	10/27 (37%)
		PDZ_FRMPD1_3_4-like	259..333	CDD:467250	42/73 (58%)
		FERM_F1_FRMPD1_like	393..482	CDD:340608	46/88 (52%)
		B41	396..617	CDD:214604	102/220 (46%)
		PH-like	613..715	CDD:473070	29/112 (26%)
		PHA03247	<1105..1377	CDD:223021	83/454 (18%)
Frmpd4	XP_017457487.1	WW	36..65	CDD:238122	11/31 (35%)
		PDZ_FRMPD1_3_4-like	78..152	CDD:467250	42/73 (58%)
		FERM_F1_FRMPD4	201..294	CDD:340690	48/92 (52%)
		B41	205..424	CDD:214604	102/220 (46%)
		FERM_C_FRMPD1_FRMPD3_FRMPD4	420..524	CDD:270004	28/109 (26%)
		LGNbd_FRMPD4	973..1021	CDD:409274	10/58 (17%)