DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42788 and MAGI3

DIOPT Version :9

Sequence 1:	NP_731964.2	Gene:	CG42788 / 41817	FlyBaseID:	FBgn0261859	Length:	1560	Species:	Drosophila melanogaster
Sequence 2:	NP_001136254.1	Gene:	MAGI3 / 260425	HGNCID:	29647	Length:	1481	Species:	Homo sapiens

Alignment Length:	1331	Identity:	256/1331 - (19%)
Similarity:	423/1331 - (31%)	Gaps:	524/1331 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 EKLKPGWSVHVGKEGRLYYCNHMTQSAGWLPA-----------CEDWSKHEELSYGWERAIDSKG 228
            |.|...|.:.....|.:|:.:|.|::..||..           |||    .||.||||:..|.:.
Human   293 EPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCED----GELPYGWEKIEDPQY 353

  Fly   229 RSYYINHLNKTTTYEAP----------------------ECIRWDEHPPEPRQVQLQ---RNASL 268
            .:||::|||:.|.:|.|                      |...:...|.:.:.|.::   :.:::
Human   354 GTYYVDHLNQKTQFENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTM 418

  Fly   269 GFGF-VAGSERP---VIVRFVTEGGPSI--GKLQPGDQILAVNGEDVKDAPRDHVIQLVR--ACE 325
            |||| :.|.:||   :.|:.|.:.||:.  ||:.|||.|:.:||..|.......|:|:.:  ...
Human   419 GFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVN 483

  Fly   326 SQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLFPPSAFSLGDICV 390
            ..|||.:|:                                       |.||  |.
Human   484 QYVNLTLCR---------------------------------------GYPL--PD--------- 498

  Fly   391 PPMANVLKVFLENGQTKSFKYDATTTVQDVVSS--LLDKLCLCCGELFSLVLEHVKSLKRNKLTL 453
                                 |:...|.|:|::  :::...|..||                 |.
Human   499 ---------------------DSEDPVVDIVAATPVINGQSLTKGE-----------------TC 525

  Fly   454 LDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERF----AP 514
            ::||:      .:|||..|              |...:..|.|....|...:|.:::|.    :.
Human   526 MNPQD------FKPGAMVL--------------EQNGKSGHTLTGDGLNGPSDASEQRVSMASSG 570

  Fly   515 ELQPELALRLAALHMHQHALANNFAPAKLTVKLVE--REFG-----------LERFVPVSLFEGM 566
            ..||||                      :|:.|::  :.||           ::..:.....:|:
Human   571 SSQPEL----------------------VTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGL 613

  Fly   567 KRKELRRLISHFLKLNAEMTGSSSKVLTQLQAKLHYLDIIASLPSYGAKC--------------- 616
            ::.::.:.|.|          .:.:.||.||.    ::::...| .||..
Human   614 QKGDIIKEIYH----------QNVQNLTHLQV----VEVLKQFP-VGADVPLLILRGGPPSPTKT 663

  Fly   617 --FSTNQRE---GVERVLLVSPR---FGLSQISSARNSVQPQPI-----SAIEDFTHVVVNREDD 668
              ..|:::|   .:|.:....|:   |..|.|.|....:.|..:     :..||        :..
Human   664 AKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYED--------KPP 720

  Fly   669 VTCSVSIFM-LGDRAVKFIMEDRDGCEFSLVLG-----------GYYR----------------- 704
            .|..:.:|: ..:....|.:...||.:.|:.:|           |..|
Human   721 NTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKS 785

  Fly   705 ------LLT-----GNVLNILR------EREPNDEDNAPGFLSQHTVLPAGWSYLLPFHTRAHSV 752
                  |:|     |:||..:|      |::|.| |::..|:|.....|         ......|
Human   786 HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPED-DSSQAFISTQNGSP---------RLNRAEV 840

  Fly   753 NFLMAP--PYHPLVQRGQ-------LQQQSSIQAPSSLPYVMDLDLHSVMATELLEEAAKDSGLS 808
            ....||  ||..::||.:       :....:...|..:|:                   |...:.
Human   841 PARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPH-------------------KIGRVI 886

  Fly   809 DSSGSNYCEGRSHLGSHQLEAKNEQVLRRVQELQHLVQTSEQYLSEQEQGGGGGGVAMLEFDSDC 873
            :.|.::.| |:..:|.| :.|.|.|   .:.||.|                          |:..
Human   887 EGSPADRC-GKLKVGDH-ISAVNGQ---SIVELSH--------------------------DNIV 920

  Fly   874 DSLNSSKVSSTEGSQGGTILGPGAIIPPGHPLKHSDSLTLLAETINHELSGITQGLNAIPESAPV 938
            ..:..:.|:.|                          ||::||..:|   |...|.|
Human   921 QLIKDAGVTVT--------------------------LTVIAEEEHH---GPPSGTN-------- 948

  Fly   939 STSAPPTPATPKRKPSLCSTSSPRPQRKLNGFSQLLSDLQAL--------GTDFSQSESDSESVA 995
              ||..:||...|         |..|.:.|   .:..|..||        .|.:..|.||.:.:|
Human   949 --SARQSPALQHR---------PMGQSQAN---HIPGDRSALEGEIGKDVSTSYRHSWSDHKHLA 999

  Fly   996 SPAQSPTTRRPQMMLLQAAGSSAG---SVAPAKQQLSQRSSFGLHSPDGTHFGAETKDYNLREYL 1057
                     :|...::...||...   ...|.:.:...| .||.....|       |:||:..::
Human  1000 ---------QPDTAVISVVGSRHNQNLGCYPVELERGPR-GFGFSLRGG-------KEYNMGLFI 1047

  Fly  1058 QQLKEISNAASADTDVAARQLSEIYGFEVREDTFIETDTDLIDL--------RAIPPPQT---PD 1111
            .:|.|...|..........|:.||.|    |.|...|.|..|:|        ..:..|.|   ||
Human  1048 LRLAEDGPAIKDGRIHVGDQIVEING----EPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPD 1108

  Fly  1112 ----ELDSLSLMNA-------APPKG-FEGKAEEL------DSFLQQIMVAPPTQKATPAKELTP 1158
                ::::.|..|.       .||.. |....||.      :|...||     .:||...|::.|
Human  1109 HGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEESHVPVIEESLRVQI-----CEKAEELKDIVP 1168

  Fly  1159 EEIMSFIIPPPPNLEQQQVVAP-VETECLYSNSVQAKREFFQSVANGNNGTVSHSPHIIEYATVE 1222
            |: .|.:....|.::.|.::.. |......|:...:.::....|.||                |.
Human  1169 EK-KSTLNENQPEIKHQSLLQKNVSKRDPPSSHGHSNKKNLLKVENG----------------VT 1216

  Fly  1223 RKSKFSCCPTSKKEEQPGQEELQP--------PPRTPTTEQLSPPPARPPKSAELLQR------- 1272
            |:.: |..| .|...|..:|.|..        |.|.|..:.|||.... .||.::..|
Human  1217 RRGR-SVSP-KKPASQHSEEHLDKIPSPLKNNPKRRPRDQSLSPSKGE-NKSCQVSTRAGSGQDQ 1278

  Fly  1273 --------YSPKKQVRIAASPVMQPQERREL 1295
                    .|||||.:|..|......|.:.|
Human  1279 CRKSRGRSASPKKQQKIEGSKAPSNAEAKLL 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809	6/25 (24%)
		WW	218..246	CDD:238122	13/49 (27%)
		PDZ_signaling	257..333	CDD:238492	26/86 (30%)
		B41	396..617	CDD:214604	38/256 (15%)
		UBQ	396..477	CDD:294102	14/82 (17%)
		FERM_M	495..617	CDD:278785	22/155 (14%)
		PH-like	613..715	CDD:302622	27/169 (16%)
MAGI3	NP_001136254.1	Interaction with ADRB1 and TGFA. /evidence=ECO:0000250	18..106
		PDZ_signaling	24..101	CDD:238492
		NK	123..>197	CDD:327404
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..273
		WW	294..326	CDD:197736	8/31 (26%)
		WW	342..372	CDD:238122	13/29 (45%)
		Interaction with PTEN. /evidence=ECO:0000269\|PubMed:10748157	410..492		25/81 (31%)
		PDZ	413..493	CDD:214570	26/118 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..570		5/27 (19%)
		PDZ	575..656	CDD:214570	16/117 (14%)
		Interaction with ADGRB1. /evidence=ECO:0000269\|PubMed:10748157	726..808		13/81 (16%)
		PDZ_signaling	726..807	CDD:238492	13/80 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..843		4/30 (13%)
		PDZ_signaling	849..935	CDD:238492	23/161 (14%)
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269\|PubMed:10748157, ECO:0000269\|PubMed:16904289	851..938		22/162 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976		13/61 (21%)
		PDZ_signaling	1022..1100	CDD:238492	20/89 (22%)
		Red1	<1132..1461	CDD:311769	46/203 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1481		34/160 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010