DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42788 and Magi3

DIOPT Version :10

Sequence 1:NP_731964.2 Gene:CG42788 / 41817 FlyBaseID:FBgn0261859 Length:1560 Species:Drosophila melanogaster
Sequence 2:NP_620784.3 Gene:Magi3 / 245903 RGDID:621362 Length:1470 Species:Rattus norvegicus


Alignment Length:1488 Identity:289/1488 - (19%)
Similarity:471/1488 - (31%) Gaps:594/1488 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 EKLKPGWSVHVGKEGRLYYCNHMTQSAGWLPA-----------CEDWSKHEELSYGWERAIDSKG 228
            |.|...|.:.....|.:|:.:|.|::..||..           |||    .||.||||:..|.:.
  Rat   296 EPLPKNWEMAYTDTGTIYFIDHNTKTTTWLDPRLCKKAKAPEDCED----GELPYGWEKIEDPQY 356

  Fly   229 RSYYINHLNKTTTYEAP----------------------ECIRWDEHPPEPRQVQLQ---RNASL 268
            .:||::|||:.|.:|.|                      |...:...|.:.:.|.::   :.:::
  Rat   357 GTYYVDHLNQKTQFENPVEEAKRKKQIGQAETHSAKTDVERAHFTRDPSQLKGVLVRASLKKSTM 421

  Fly   269 GFGF-VAGSERP---VIVRFVTEGGPSI--GKLQPGDQILAVNGEDVKDAPRDHVIQLVR--ACE 325
            |||| :.|.:||   :.|:.|.:.||:.  ||:.|||.|:.:||..|.......|:|:.:  ...
  Rat   422 GFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKMAPGDVIVDINGNCVLGHTHADVVQMFQLVPVN 486

  Fly   326 SQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLFPPSAFSLGDICV 390
            ..|||.:|:                                               .::|.|...
  Rat   487 QYVNLTLCR-----------------------------------------------GYALPDDSE 504

  Fly   391 PPMANVLKVF-LENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRNKLTLL 454
            .|:.:::... :.|||:.: |.:|..:.||.             :|.::||:  ::.|..||...
  Rat   505 DPVVDIVAATPVINGQSLA-KGEACMSTQDF-------------KLGAMVLD--QNGKSGKLLSS 553

  Fly   455 DPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAPELQPE 519
            |                                            :|...:|.|::|        
  Rat   554 D--------------------------------------------HLNGPSDSNEQR-------- 566

  Fly   520 LALRLAALHMHQHALANNFAPAKLTVKLVE--REFG-----------LERFVPVSLFEGMKRKEL 571
                 |:|     |.:.:..|..:|:.||:  :.||           ::..:.....:|:::.::
  Rat   567 -----ASL-----ASSGSSQPELVTIPLVKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDI 621

  Fly   572 RRLISHFLKLNAEMTGSSSKVLTQLQA--KLHYLDIIASLPSY---GAKC-------FSTNQRE- 623
            .:.|.|          .:.:.||.||.  .|....:.|.:|..   |..|       ..|:.:| 
  Rat   622 IKEIYH----------QNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKMKTDTKET 676

  Fly   624 --GVERVLLVSPR---FGLSQISSARNSVQPQPI-----SAIEDFTHVVVNREDDVTCSVSIFM- 677
              .:|.:...:|:   |..|.|.|....:.|..:     :..||        :...|..:.:|: 
  Rat   677 SGSLETINEPTPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYED--------KPPNTKDLDVFLR 733

  Fly   678 LGDRAVKFIMEDRDGCEFSLVLG-----------GYYR-----------------------LLT- 707
            ..:....|.:...||.:.|:.:|           |..|                       |:| 
  Rat   734 KQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTT 798

  Fly   708 ----GNVLNILRER----EPNDEDNAPGFLSQ-------HTVLPAGWSYLLPFHTRAHSVNFLMA 757
                |:||..:|.:    |...||.:|...||       .|.||          ||:       |
  Rat   799 AARNGHVLLTVRRKIFYGEKQPEDESPQAFSQSGSPRLNRTELP----------TRS-------A 846

  Fly   758 P--PYHPLVQRGQ-------LQQQSSIQAPSSLPYVMDLDLHSVMATELLEEAAKDSGLSDSSGS 813
            |  .|..::||.:       :....|...|..:|:                   |...:.|.|.:
  Rat   847 PQESYDVILQRKENEGFGFVILTSKSKPPPGVIPH-------------------KIGRVIDGSPA 892

  Fly   814 NYCEGRSHLGSHQLEAKNEQVLRRVQELQHLVQTSEQYLSEQEQGGGGGGVAMLEFDSDCDSLNS 878
            :.| ||..:|.| :.|.|.|   .:.:|.|                          |:....:..
  Rat   893 DRC-GRLKVGDH-ISAVNGQ---SIVDLSH--------------------------DNIVQLIKD 926

  Fly   879 SKVSSTEGSQGGTILGPGAIIPPGHPLKHSDSLTLLAETINHELSGITQGLNAIPESAPVSTSAP 943
            :.|:.|                          ||::||..:|   |...|.|          ||.
  Rat   927 AGVTVT--------------------------LTVVAEEEHH---GPPSGTN----------SAR 952

  Fly   944 PTPATPKRKPSLC-STSSPRPQRKLNGFSQLLSDLQALGTD----FSQSESDSESVASPAQSPTT 1003
            .:||...|..... :|..|..:..|.|         .:|.|    :..|.||.:.:|        
  Rat   953 QSPALQHRPMGQAQATHIPGDRTALEG---------EVGKDVCSSYRHSWSDHKHLA-------- 1000

  Fly  1004 RRPQMMLLQAAGS----SAGSVAPAKQQLSQRSSFGLHSPDGTHFGAETKDYNLREYLQQLKEIS 1064
             :|...::...||    |.|.. |.:.:...| .||.....|       |:||:..::.:|.|..
  Rat  1001 -QPDTAVISVVGSRHSQSLGCY-PVELERGPR-GFGFSLRGG-------KEYNMGLFILRLAEDG 1055

  Fly  1065 NAASADTDVAARQLSEIYGFEVREDTFIETDTDLIDL--------RAIPPPQT---PDELD---- 1114
            .|..........|:.||.|    |.|...|.|..|:|        ..:..|.|   ||..|    
  Rat  1056 PAIKDGRIHVGDQIVEING----EPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDIY 1116

  Fly  1115 SLSLMNA-----APPKGFEGKA---EEL------DSFLQQIMVAPPTQKATPAKEL--TPEEIMS 1163
            |.|..|.     .||......|   ||.      ||.::       .|....|:||  |.:|..|
  Rat  1117 SPSSSNVIYDEQPPPLPSSHSAATFEESHVPVTEDSLIR-------VQTCEKAEELKDTVQEKKS 1174

  Fly  1164 FIIPPPPNLEQQQVVAPVETECLYSNSVQAKREFFQSVANGNNGTVSHSPHIIEYATVERKSKFS 1228
            .:....|.::.|.|...|..:    :..::.....:::..|.||             |.|:.: |
  Rat  1175 TLNGSQPEMKYQSVQKNVSKK----DPSRSHGHGDKNLPKGENG-------------VTRRGR-S 1221

  Fly  1229 CCPTSKKEEQPGQEELQPPPRTPTTE--------QLSP-----------------PPARPPKSAE 1268
            ..| .|...:..:|.|:..||...::        .|||                 .|.|..:.  
  Rat  1222 ASP-KKSVNRHSEEHLEKIPRPLRSDPKGKSRDRSLSPRKGENKGQVTIKAGSGQDPCRKDRG-- 1283

  Fly  1269 LLQRYSPKKQVRIAA------------------------SPVMQPQ-------ERRELCPPQL-- 1300
              :..||:||.:|..                        ||...|:       .|::|...||  
  Rat  1284 --RSSSPRKQQKIGGNSLSNTEGKLSEAGSRRAAGLSSDSPEQLPEGKEKSGVSRKDLKLSQLGK 1346

  Fly  1301 -----PPRGSPTLD-----GSQSSPT--NAVSGPKKPPLPPIACRPRPSNGVNSPNSSSP----- 1348
                 |.:.|..:|     ..::|.|  ..||..:|...|....|.|...|.:...|:.|     
  Rat  1347 NRTRSPEKRSSKVDEASLPSKKTSDTASRVVSEKEKGRKPGTGERSRDKTGESVQTSAKPLTQEA 1411

  Fly  1349 --------------------GSAP----PAHYSPPIPATVRLPHLNQANGTLPLLPKK 1382
                                |.||    |...:|..|...|:|..|:..||..:..|:
  Rat  1412 GEKMALSKASEVTDRGKERAGGAPESSSPVKKAPITPGPWRVPRANKVTGTAGMADKQ 1469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42788NP_731964.2 WW 177..203 CDD:459800 6/25 (24%)
WW 218..246 CDD:238122 13/49 (27%)
PDZ_FRMPD1_3_4-like 259..333 CDD:467250 26/84 (31%)
FERM_F1_FRMPD1_like 393..482 CDD:340608 14/89 (16%)
B41 396..617 CDD:214604 39/246 (16%)
PH-like 613..715 CDD:473070 27/159 (17%)
PHA03247 <1105..1377 CDD:223021 80/393 (20%)
Magi3NP_620784.3 PDZ0_MAGI-1_3-like 14..106 CDD:467212
Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:16316992 18..108
NK 125..>199 CDD:450170
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266
HUL4 <211..>373 CDD:227354 26/80 (33%)
WW 299..329 CDD:238122 7/29 (24%)
WW 345..375 CDD:238122 13/29 (45%)
PDZ1_MAGI-1_3-like 411..495 CDD:467213 25/83 (30%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 25/81 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..575 9/86 (10%)
PDZ2_MAGI-1_3-like 577..658 CDD:467214 16/90 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 665..700 7/34 (21%)
PDZ3_MAGI-1_3-like 727..811 CDD:467215 13/83 (16%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 13/81 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..847 10/45 (22%)
PDZ4_MAGI-1_3-like 851..936 CDD:467216 24/160 (15%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 24/162 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..976 11/49 (22%)
PDZ5_MAGI-1_3-like 1020..1102 CDD:467217 21/94 (22%)
PTZ00112 1115..>1405 CDD:240274 63/319 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1124..1146 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1470 62/326 (19%)
Blue background indicates that the domain is not in the aligned region.

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