DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42788 and Magi3

DIOPT Version :9

Sequence 1:NP_731964.2 Gene:CG42788 / 41817 FlyBaseID:FBgn0261859 Length:1560 Species:Drosophila melanogaster
Sequence 2:NP_620784.3 Gene:Magi3 / 245903 RGDID:621362 Length:1470 Species:Rattus norvegicus


Alignment Length:1488 Identity:289/1488 - (19%)
Similarity:471/1488 - (31%) Gaps:594/1488 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 EKLKPGWSVHVGKEGRLYYCNHMTQSAGWLPA-----------CEDWSKHEELSYGWERAIDSKG 228
            |.|...|.:.....|.:|:.:|.|::..||..           |||    .||.||||:..|.:.
  Rat   296 EPLPKNWEMAYTDTGTIYFIDHNTKTTTWLDPRLCKKAKAPEDCED----GELPYGWEKIEDPQY 356

  Fly   229 RSYYINHLNKTTTYEAP----------------------ECIRWDEHPPEPRQVQLQ---RNASL 268
            .:||::|||:.|.:|.|                      |...:...|.:.:.|.::   :.:::
  Rat   357 GTYYVDHLNQKTQFENPVEEAKRKKQIGQAETHSAKTDVERAHFTRDPSQLKGVLVRASLKKSTM 421

  Fly   269 GFGF-VAGSERP---VIVRFVTEGGPSI--GKLQPGDQILAVNGEDVKDAPRDHVIQLVR--ACE 325
            |||| :.|.:||   :.|:.|.:.||:.  ||:.|||.|:.:||..|.......|:|:.:  ...
  Rat   422 GFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKMAPGDVIVDINGNCVLGHTHADVVQMFQLVPVN 486

  Fly   326 SQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLFPPSAFSLGDICV 390
            ..|||.:|:                                               .::|.|...
  Rat   487 QYVNLTLCR-----------------------------------------------GYALPDDSE 504

  Fly   391 PPMANVLKVF-LENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRNKLTLL 454
            .|:.:::... :.|||:.: |.:|..:.||.             :|.::||:  ::.|..||...
  Rat   505 DPVVDIVAATPVINGQSLA-KGEACMSTQDF-------------KLGAMVLD--QNGKSGKLLSS 553

  Fly   455 DPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAPELQPE 519
            |                                            :|...:|.|::|        
  Rat   554 D--------------------------------------------HLNGPSDSNEQR-------- 566

  Fly   520 LALRLAALHMHQHALANNFAPAKLTVKLVE--REFG-----------LERFVPVSLFEGMKRKEL 571
                 |:|     |.:.:..|..:|:.||:  :.||           ::..:.....:|:::.::
  Rat   567 -----ASL-----ASSGSSQPELVTIPLVKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDI 621

  Fly   572 RRLISHFLKLNAEMTGSSSKVLTQLQA--KLHYLDIIASLPSY---GAKC-------FSTNQRE- 623
            .:.|.|          .:.:.||.||.  .|....:.|.:|..   |..|       ..|:.:| 
  Rat   622 IKEIYH----------QNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKMKTDTKET 676

  Fly   624 --GVERVLLVSPR---FGLSQISSARNSVQPQPI-----SAIEDFTHVVVNREDDVTCSVSIFM- 677
              .:|.:...:|:   |..|.|.|....:.|..:     :..||        :...|..:.:|: 
  Rat   677 SGSLETINEPTPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYED--------KPPNTKDLDVFLR 733

  Fly   678 LGDRAVKFIMEDRDGCEFSLVLG-----------GYYR-----------------------LLT- 707
            ..:....|.:...||.:.|:.:|           |..|                       |:| 
  Rat   734 KQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTT 798

  Fly   708 ----GNVLNILRER----EPNDEDNAPGFLSQ-------HTVLPAGWSYLLPFHTRAHSVNFLMA 757
                |:||..:|.:    |...||.:|...||       .|.||          ||:       |
  Rat   799 AARNGHVLLTVRRKIFYGEKQPEDESPQAFSQSGSPRLNRTELP----------TRS-------A 846

  Fly   758 P--PYHPLVQRGQ-------LQQQSSIQAPSSLPYVMDLDLHSVMATELLEEAAKDSGLSDSSGS 813
            |  .|..::||.:       :....|...|..:|:                   |...:.|.|.:
  Rat   847 PQESYDVILQRKENEGFGFVILTSKSKPPPGVIPH-------------------KIGRVIDGSPA 892

  Fly   814 NYCEGRSHLGSHQLEAKNEQVLRRVQELQHLVQTSEQYLSEQEQGGGGGGVAMLEFDSDCDSLNS 878
            :.| ||..:|.| :.|.|.|   .:.:|.|                          |:....:..
  Rat   893 DRC-GRLKVGDH-ISAVNGQ---SIVDLSH--------------------------DNIVQLIKD 926

  Fly   879 SKVSSTEGSQGGTILGPGAIIPPGHPLKHSDSLTLLAETINHELSGITQGLNAIPESAPVSTSAP 943
            :.|:.|                          ||::||..:|   |...|.|          ||.
  Rat   927 AGVTVT--------------------------LTVVAEEEHH---GPPSGTN----------SAR 952

  Fly   944 PTPATPKRKPSLC-STSSPRPQRKLNGFSQLLSDLQALGTD----FSQSESDSESVASPAQSPTT 1003
            .:||...|..... :|..|..:..|.|         .:|.|    :..|.||.:.:|        
  Rat   953 QSPALQHRPMGQAQATHIPGDRTALEG---------EVGKDVCSSYRHSWSDHKHLA-------- 1000

  Fly  1004 RRPQMMLLQAAGS----SAGSVAPAKQQLSQRSSFGLHSPDGTHFGAETKDYNLREYLQQLKEIS 1064
             :|...::...||    |.|.. |.:.:...| .||.....|       |:||:..::.:|.|..
  Rat  1001 -QPDTAVISVVGSRHSQSLGCY-PVELERGPR-GFGFSLRGG-------KEYNMGLFILRLAEDG 1055

  Fly  1065 NAASADTDVAARQLSEIYGFEVREDTFIETDTDLIDL--------RAIPPPQT---PDELD---- 1114
            .|..........|:.||.|    |.|...|.|..|:|        ..:..|.|   ||..|    
  Rat  1056 PAIKDGRIHVGDQIVEING----EPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDIY 1116

  Fly  1115 SLSLMNA-----APPKGFEGKA---EEL------DSFLQQIMVAPPTQKATPAKEL--TPEEIMS 1163
            |.|..|.     .||......|   ||.      ||.::       .|....|:||  |.:|..|
  Rat  1117 SPSSSNVIYDEQPPPLPSSHSAATFEESHVPVTEDSLIR-------VQTCEKAEELKDTVQEKKS 1174

  Fly  1164 FIIPPPPNLEQQQVVAPVETECLYSNSVQAKREFFQSVANGNNGTVSHSPHIIEYATVERKSKFS 1228
            .:....|.::.|.|...|..:    :..::.....:::..|.||             |.|:.: |
  Rat  1175 TLNGSQPEMKYQSVQKNVSKK----DPSRSHGHGDKNLPKGENG-------------VTRRGR-S 1221

  Fly  1229 CCPTSKKEEQPGQEELQPPPRTPTTE--------QLSP-----------------PPARPPKSAE 1268
            ..| .|...:..:|.|:..||...::        .|||                 .|.|..:.  
  Rat  1222 ASP-KKSVNRHSEEHLEKIPRPLRSDPKGKSRDRSLSPRKGENKGQVTIKAGSGQDPCRKDRG-- 1283

  Fly  1269 LLQRYSPKKQVRIAA------------------------SPVMQPQ-------ERRELCPPQL-- 1300
              :..||:||.:|..                        ||...|:       .|::|...||  
  Rat  1284 --RSSSPRKQQKIGGNSLSNTEGKLSEAGSRRAAGLSSDSPEQLPEGKEKSGVSRKDLKLSQLGK 1346

  Fly  1301 -----PPRGSPTLD-----GSQSSPT--NAVSGPKKPPLPPIACRPRPSNGVNSPNSSSP----- 1348
                 |.:.|..:|     ..::|.|  ..||..:|...|....|.|...|.:...|:.|     
  Rat  1347 NRTRSPEKRSSKVDEASLPSKKTSDTASRVVSEKEKGRKPGTGERSRDKTGESVQTSAKPLTQEA 1411

  Fly  1349 --------------------GSAP----PAHYSPPIPATVRLPHLNQANGTLPLLPKK 1382
                                |.||    |...:|..|...|:|..|:..||..:..|:
  Rat  1412 GEKMALSKASEVTDRGKERAGGAPESSSPVKKAPITPGPWRVPRANKVTGTAGMADKQ 1469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42788NP_731964.2 WW 177..203 CDD:278809 6/25 (24%)
WW 218..246 CDD:238122 13/49 (27%)
PDZ_signaling 257..333 CDD:238492 26/86 (30%)
B41 396..617 CDD:214604 39/246 (16%)
UBQ 396..477 CDD:294102 14/81 (17%)
FERM_M 495..617 CDD:278785 25/146 (17%)
PH-like 613..715 CDD:302622 27/159 (17%)
Magi3NP_620784.3 Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:16316992 18..108
PDZ_signaling 24..103 CDD:238492
NK 125..>199 CDD:418433
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266
HUL4 <211..>373 CDD:227354 26/80 (33%)
WW 299..329 CDD:238122 7/29 (24%)
WW 345..375 CDD:238122 13/29 (45%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 25/81 (31%)
PDZ 416..496 CDD:214570 26/126 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..575 9/86 (10%)
PDZ 578..659 CDD:214570 15/90 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 665..700 7/34 (21%)
PDZ 729..812 CDD:214570 14/82 (17%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 13/81 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..847 10/45 (22%)
PDZ_signaling 851..936 CDD:238492 24/160 (15%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 24/162 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..976 11/49 (22%)
PDZ_signaling 1023..1101 CDD:238492 20/89 (22%)
PTZ00112 1115..>1405 CDD:240274 63/319 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1124..1146 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1470 62/326 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10316
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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