DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42788 and Frmpd3

DIOPT Version :9

Sequence 1:	NP_731964.2	Gene:	CG42788 / 41817	FlyBaseID:	FBgn0261859	Length:	1560	Species:	Drosophila melanogaster
Sequence 2:	NP_001307875.1	Gene:	Frmpd3 / 245643	MGIID:	3646547	Length:	1774	Species:	Mus musculus

Alignment Length:	1553	Identity:	398/1553 - (25%)
Similarity:	606/1553 - (39%)	Gaps:	369/1553 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 ECIRWDEHPPEP-RQVQLQRNASLGFGFVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDV 309
            ||:   :.|.|. |||.:.|:...||||||||||||:||.|..||||..||..||||:|:|.|||
Mouse    10 ECV---QLPAETLRQVTIHRDPIYGFGFVAGSERPVVVRSVRPGGPSEDKLLAGDQIVAINEEDV 71

  Fly   310 KDAPRDHVIQLVRACESQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCV-- 372
            .:|||:..|:|:|:.:..:.|.|..  .|   ...||..:||.|:|||||.|.:|||:|.|.:
Mouse    72 SEAPRERFIELIRSAKESIVLTVLH--TH---QSPKSAFISAAKKAKLRSNPVKVRFSEQVTIGE 131

  Fly   373 NGAPLFPPSAFSLGDICVPPMANVLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFS 437
            ..|.:....|..|    :|   |||||||||||.|||.:|..|||:||:::|.|:|.|...|.|:
Mouse   132 TDAKMMKKEALLL----IP---NVLKVFLENGQIKSFTFDGRTTVKDVMATLQDRLSLRSIEHFA 189

  Fly   438 LVLEHVKSLKRNKLTLLDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQ 502
            ||||:....:.:|..:|..::.||.:..|...|.::|||||:|.|....||.:||..|.:|||:|
Mouse   190 LVLEYTGPEQNHKFLILQDKQPLAYVVQRTHYHGMKCLFRISFFPKDPVELLRRDPAAFEYLYIQ 254

  Fly   503 CCNDVNQERFAPELQPELALRLAALHMHQHALANNFAPA-KLTVKLVEREFGLERFVPVSLFEGM 566
            ..|||.:|||..|.:||:.|.|||||::....|..  |: |:|:|.||:|:|||.|:|.||.:|:
Mouse   255 SRNDVIRERFGMEPKPEMLLGLAALHIYITVSATR--PSQKITLKNVEKEWGLEPFLPPSLLQGI 317

  Fly   567 KRKELRRLISHFLKLNAEMTGSSSKVLTQLQAKLHYLDIIASLPSYGAKCFSTNQREGVER---- 627
            |.|.||:.:|..||.: :|..|||...:.:||||.||.|:..||::....|:|   .|::.
Mouse   318 KEKNLRKSLSQQLKAH-QMHPSSSTKGSAIQAKLQYLRILNELPTFTGVLFNT---VGLDEKHSA 378

  Fly   628 -VLLVSPRFGLSQISSARNSVQPQPISAIEDFTHVVVNREDDVTCSVSIFMLGDRAVKFIMEDRD 691
             .|||.||.|:|.:...:.:: ...:|.....:.:.:.||:.....|...::..:.:..:||..:
Mouse   379 TTLLVGPRHGISHVIDLKTNL-TTVLSEFSKISKIQLFRENQGVARVETSIMDAKPLVLLMEWPE 442

  Fly   692 GCEFSLVLGGYYRLLTGNVLNILREREPNDEDNAPGFL------SQHTVLPAGW------SYLLP 744
            ...|:.::.||.|||..:...:.  ..|..:...|..:      |.|..:..|.      ||:..
Mouse   443 ATNFACLIAGYCRLLLDSRKMVF--SRPASQPLPPPMIKADHMHSAHRPVTGGHLGKKESSYVGS 505

  Fly   745 FHTRAHSVNFLMAPP----------YHPLVQRGQLQQQSSIQAPSSLPYVMDLDLHSVMATELLE 799
            ..|.....:....||          .|...||.:.:.::.:.             .:::..|...
Mouse   506 VGTSPRKSSRCTTPPADSELVSFCYLHMREQRKEQESRTDVN-------------ENLIFFEETR 557

  Fly   800 EAAKDSGLSDSSGSNY----------------CEGRSH-------LGSHQLEAKNEQVLRRVQEL 841
            ...|....|.|||..|                |..|:.       ||:..|....:....::||
Mouse   558 PRTKSDPTSKSSGQGYEVIPDDFDAASLDHEPCASRARSYTLDNSLGAEALNFYCDSCKVKLQE- 621

  Fly   842 QHLVQTSEQYLSEQEQGGGGGGVAMLEFDSDCDSLN----SSKVSSTEGSQGGTILGPGAIIPPG 902
                          :.|...||......|:..|.::    .|:....|..:..::|...|..|||
Mouse   622 --------------QMGPRKGGRPGSSRDNMVDLMSLPPPGSEEEEEEEDETTSLLPAIAAPPPG 672

  Fly   903 HPLKHSDS--------------------------LTLL-----------AETINHELSGITQGLN 930
            .....||.                          :||:           |:.::..|....|.|.
Mouse   673 FRDNSSDEDDPKRRAVQSQEQGRHLRGLLYDEIPVTLIDSVQTRTVRDHAQELDDALVSTLQALE 737

  Fly   931 AI--PESAPVSTSAPPTPATPKRKPSLCSTSSPRPQRKLNG----FSQLLSDLQALGTDFSQSES 989
            |:  .|..|    .||.|.|    ..|...::..|:..|:.    .|..|:|:..:.:...|.::
Mouse   738 ALAASEDGP----HPPPPQT----AGLIVLATITPESSLDSGHETNSSELTDMSEMMSAMKQHQN 794

  Fly   990 DSESVASP-------AQSPTTRRPQMMLLQAAGSSAGSVAPAKQQLSQRSSFGLHSPDGTHFGAE 1047
            .:..:|..       |:.....|.|....||..::..::.|.....|.:.:....||..|  ||.
Mouse   795 TTYFLAQHLNKDSLLARKDLPFRIQSCAAQAVLTAPYALGPPDPNPSPQPAVTGQSPAPT--GAR 857

  Fly  1048 TKDYNLREYLQQLKEISNAASADTDVAARQLSEIYGFEVREDTFIETDTDLIDLRAIPPPQTPDE 1112
            .|.......:|..:..|.|..   ...:.||||              ..:|..|..:|..:.|..
Mouse   858 RKIPQSEVQVQGDRPYSLAVH---PALSPQLSE--------------QKNLSLLPPVPEDRGPGH 905

  Fly  1113 LDS---LSLMNAAPPKGFEGKAEELDSFLQQIMVAP-----PTQKATPAKELTPEEIMSFIIPPP 1169
            ..:   :||.:|.|....|..:|..::..:::.::|     |....|||       |:|..:
Mouse   906 SRAGLEMSLRSATPSLSEEQVSELRENLPKEVRLSPKLILDPKGNVTPA-------IISAAL--- 960

  Fly  1170 PNLEQQQVV------APVETECLYSNSVQAKREFFQSVANGNNGTVSHSPHI-IEYATVERKSKF 1227
                 ||||      .|.......||..:.:.|    .:.|........|.: :..::|.:..||
Mouse   961 -----QQVVHSKSLATPGTALATPSNRGERRLE----ASMGRPEVTMSRPEVSVMSSSVSKNLKF 1016

  Fly  1228 SCCPTSKKEEQPGQEELQP----PPRTPTTEQ-----LSPPPAR------PPKSAELLQRYS--- 1274
            ...|.:.:..:..|::|.|    .||..|..:     ||||..|      ||||  .|.|.|
Mouse  1017 KMSPGAPETTRNSQQQLGPEVSASPRASTGSRADNLHLSPPEDRFPVQSFPPKS--YLSRVSRDS 1079

  Fly  1275 ---------------------PKKQVRIAA--------------------------------SPV 1286
                                 |.||..::.                                ||.
Mouse  1080 MGKQATGEVAGKGGPEGAKPPPNKQSVVSGQGDKGQLESLSKSSKLEETSLVPRAGYPMALQSPS 1144

  Fly  1287 MQPQERRELCPPQLPPRGSPTLDGSQSSPTNAVSGPK-KPPLPPIACRPRPSNGVNSPNSSSPGS 1350
            .||:.....|.|:.|   ||:   |||...:....|: :.||.|:|...:.|...:....::...
Mouse  1145 CQPRSHSPSCQPRGP---SPS---SQSRGQSPSCQPRSQSPLRPLATSRQVSTMPSRKLETTLDG 1203

  Fly  1351 APPAHYSPPIPATVRLPH--LNQANGTLPLLPKK---PQQLHGEKL------FIKNGHLIDGEAL 1404
            |..|...|..|.:.|.|.  .|..:.|.|...||   .:|...:|:      |::       |.|
Mouse  1204 AHSASEGPTKPKSSRGPFRLRNLFSATFPTRQKKETDERQAQLQKVKQYELEFLE-------ELL 1261

  Fly  1405 LAKTDVAMSGLLIKLDQVAAQCS-------VAQAAGGG----TSIDEEKFQRARNELTEQT---- 1454
            ...:...:.|..........:||       |.|..|..    .|.|.::..|.......||
Mouse  1262 KPPSQGELPGTEYLQPPAPGRCSCQLRSSPVQQGPGMSREQRRSCDCKRICRGGRPQAAQTPAPG 1326

  Fly  1455 -------------------LAL---VTASKFLVASMSDMTLITLPEHLTSCLTAIRRITELAQD- 1496
                               |:|   :...:....|:......:.||...||||......|...|
Mouse  1327 LRERERVPPTQRQPEAGPGLSLNSPINVQRIRSTSLESRECRSDPESGVSCLTTCASGGECLGDP 1391

  Fly  1497 ----MTRHTS-APLQTRNIVLKVHDV------ASSFRELVGVEIG-PIGAGQLALQAE 1542
                :.||.| :.|...:.|....||      ....||:..:|.| |:|.|..:..||
Mouse  1392 NYRKLMRHYSISELDQGDTVSLTSDVYPHPPLGMLPREVKEIESGFPVGLGPKSKCAE 1449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809
		WW	218..246	CDD:238122	398/1553 (26%)
		PDZ_signaling	257..333	CDD:238492	41/76 (54%)
		B41	396..617	CDD:214604	102/221 (46%)
		UBQ	396..477	CDD:294102	37/80 (46%)
		FERM_M	495..617	CDD:278785	56/122 (46%)
		PH-like	613..715	CDD:302622	22/106 (21%)
Frmpd3	NP_001307875.1	PDZ_signaling	19..95	CDD:238492	41/75 (55%)
		FERM_F1_FRMPD3	145..237	CDD:340689	44/94 (47%)
		B41	148..367	CDD:214604	102/221 (46%)
		FERM_C_FRMPD1_FRMPD3_FRMPD4	363..466	CDD:270004	22/108 (20%)
		PHA03307	847..>1224	CDD:223039	89/422 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849806
Domainoid	1	1.000	123	1.000	Domainoid score	I5555
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43301
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1331
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840