DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42788 and FRMPD1

DIOPT Version :10

Sequence 1:NP_731964.2 Gene:CG42788 / 41817 FlyBaseID:FBgn0261859 Length:1560 Species:Drosophila melanogaster
Sequence 2:NP_055722.2 Gene:FRMPD1 / 22844 HGNCID:29159 Length:1578 Species:Homo sapiens


Alignment Length:1496 Identity:372/1496 - (24%)
Similarity:594/1496 - (39%) Gaps:345/1496 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 EELSYGW-ERAIDSKGRSYYINHLNKTTTYEAPECIRWDEHP-----PEPRQVQLQRNASL-GFG 271
            |::...| .|:.||..|:       |....:.|.     .:|     |....|::.::..| .:|
Human    18 EQMVARWLRRSRDSSARA-------KVAAADGPA-----RNPTQTLIPVRHTVKIDKDTLLQDYG 70

  Fly   272 FVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHVIQLVRACESQVNLLVCQPM 336
            |......|:.|..||.||.:.|||.||||||.:|.|..:|...:..:.::|..|..:::.|    
Human    71 FHISESLPLTVVAVTAGGSAHGKLFPGDQILQMNNEPAEDLSWERAVDILREAEDSLSITV---- 131

  Fly   337 AHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLFPPSAFSLGD--ICVPPMANVLKV 399
            ..|.....||:.|:..|||:|::.|.:|.|||.|.::|        .|.|:  :|:|   ||||:
Human   132 VRCTSGVPKSSFLTEEKRARLKTNPVKVHFAEEVLISG--------HSQGNSLLCMP---NVLKL 185

  Fly   400 FLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRNKLTLLDPQESLARIA 464
            :|||||||:||::|.|||:|::.::.:||.:...|.|:|.||...|:.|  |.||..:|.:.::.
Human   186 YLENGQTKAFKFEANTTVKDIILTVKEKLSIRSIEYFALALEEQYSISR--LHLLHEEELIQQVV 248

  Fly   465 ARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAPELQPELALRLAALHM 529
            .|..:|..|||||:.|||....:|.:.|..|.:|||||.|:||.|||||.|::...||||||||:
Human   249 EREESHDYRCLFRVCFVPKDPLDLLKEDPVAFEYLYLQSCSDVLQERFAVEMKCSSALRLAALHI 313

  Fly   530 HQ--HALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLISHFLKLNAEMTGSSSK- 591
            .:  :|.|.   |.|:::|.:|:::|:|.|:..:|...||.|::::.||..:|.|..:.....| 
Human   314 QERIYACAQ---PQKISLKYIEKDWGIENFISPTLLRNMKGKDIKKAISFHMKRNQNLLEPRQKQ 375

  Fly   592 VLTQLQAKLHYLDIIASLPSYGAKCFST----NQREGVERVLLVSPRFGLSQISSARNSVQPQPI 652
            :::..|.:|:||.|:..|.:||.:.|:.    ..||.. ..|||..::|:||:.:::.::    :
Human   376 LISAAQLRLNYLQILGELKTYGGRIFNATLMLQDRESY-IALLVGAKYGISQVINSKLNI----M 435

  Fly   653 SAIEDF---THVVVNREDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVLGGYYRLLTGNVLNIL 714
            |.:.:|   :.|.:..|.:....|.:::...:.:..::|.....:.:.::.||||||...|.:|.
Human   436 STLAEFANISRVELTEESEKVSVVKVYLQDVKVLTLLLESNSAKDLACLIAGYYRLLVDPVTSIF 500

  Fly   715 REREPNDEDNAPGFLSQHTVLPAGWSYLLPFHTRAHS-------VNFLMAP----------PYHP 762
            .         .||...|...:.|...|    .:||.|       |:.::.|          |...
Human   501 L---------WPGNKQQAHRVSAEEGY----ESRACSDSEESSEVDCVLEPLSDRRLVKLAPCRS 552

  Fly   763 LVQRGQLQQQS-----SIQAPSSLPYVMDLDLHSVMATELLEEAAKDSGLSDS-----SGS---- 813
            |::..|....|     :.:.||:        ..:...|:..|..|.||..::|     |||    
Human   553 LIKEEQPPGNSPTPEVARRGPST--------CGASSTTDSAESEASDSANTESRGYRTSGSSESM 609

  Fly   814 --------NYC-EGRS---HLGSHQLEAKNEQVLRRVQELQHLVQTS-----------------E 849
                    :.| ..||   |.||..|.   |.:....||.:..::||                 :
Human   610 DALEEDDLDTCSSSRSTFFHFGSPGLA---ESIDSDSQEERSGIETSGFLCLLDLAQRANPQCQK 671

  Fly   850 QYLSEQ---EQGGGGGGVAMLEFD------------SDCDSLN-----SSKVSSTEGSQGG---- 890
            ...||.   |..|....::.:..|            |.|.|::     |....||...|||    
Human   672 TEFSESAALETFGWAPELSTVRLDPRLYEGSHADYYSLCSSVSPASYLSDSSESTASRQGGAPPA 736

  Fly   891 ------------TILGPGAIIPPGHPLKHSDSLTLLAETINHELSGITQGLNAI-PESAP--VST 940
                        ::|.|.|:.|   ||...|.      :.:.|.......|... |.|.|  |||
Human   737 WGQQGWTEAQPSSMLEPLALHP---PLAFEDG------SSDEEYYDAADKLTPPGPPSGPRDVST 792

  Fly   941 SAPPTPATPKRKPSLCSTSSP-----------RPQRKLNGFSQLLSDLQA----LGTDFSQSES- 989
            :.|...:...:    .|||||           :|.|: .|..:....|:.    |.||::...| 
Human   793 AEPSATSLQNK----ASTSSPENSLPCGPDGRQPSRR-GGVKKYAKTLRKRRSFLQTDYTSQVSF 852

  Fly   990 ------DSESV------------ASPAQSPTTRRPQMM-----LLQAAGSSAGSVAPAKQQLSQR 1031
                  ..|||            |..|.|||....|.|     ||:.  .:.|.:||.::..|..
Human   853 PLVPSASLESVDDVCYYDREPYLALGAPSPTVSSLQDMQGEPGLLET--KALGLLAPLRETKSTN 915

  Fly  1032 SSFGLHSPDGTHFGAETK-----------------DYNLRE---------YLQQLKEISNAASAD 1070
            .:..:...:....  |||                 |.|.:|         ........||..|:.
Human   916 PASRVMEMEPETM--ETKSVIDSRVSSISAIRFRIDPNNKENSGVVPAASSSASTPHCSNPGSSG 978

  Fly  1071 TDVAARQLSEIY-------GFEVREDTFIETDTDLIDLRAIPPPQTPDELDSLSLMNAAPPKGFE 1128
            .|.|..:.|:|.       |...:|.|....|:........|.|.......:..|.|.:.....|
Human   979 PDTAQARPSQILPLSQDLDGIAPKEPTIEHGDSSFSLSSGDPNPDRACLASNPGLNNVSQGDTLE 1043

  Fly  1129 GKAEE-------LDSF----LQQI-------MVAPPTQKATPAKELTPEEIMSFIIPPPPNLEQQ 1175
            .:.|.       |:||    :|:.       :::|..:..:....:.|.|.::.|  |.....|.
Human  1044 LQLEPHVQLEMGLESFCTNHIQETAPKYTEPLLSPRDEPRSDECGINPGEKIASI--PTKEEPQG 1106

  Fly  1176 QVVAPVETECLYSNSVQAKREFFQSVANGNNGTVSHSPHIIEYATVERKSKFSCCPTSKKEEQP- 1239
            |:....:.|....|.....:|..:..:..:.|.||::..    .|::..|......||...:.| 
Human  1107 QLSLERDREVTNKNGTNVFQEESRKDSGDSPGDVSNNVS----QTLDISSPAGKIVTSLSLDAPV 1167

  Fly  1240 -GQEELQP-PPRTPTTEQLSPPPARPPKSAELLQRYSPKKQVRIAASPVMQPQERRELCPPQLPP 1302
             |.|::.| |||.|..:...||       .:..|....|..|.:...|..  ...::...|.:||
Human  1168 TGTEQIPPHPPRDPQGQSREPP-------GQGCQAQEQKLFVELDLDPDF--FLGKQTVSPAVPP 1223

  Fly  1303 RGSPTLDGSQSSPTNAVSGPKKPPLPPIACRPRPSNGVNSPNSSSPGSAPPAHYSPPIPATVRLP 1367
                  :|.::...|.|:|      ..||.|..|.....:|..|.|         .|:|.....|
Human  1224 ------EGIKAEAPNHVTG------QDIAPRDSPEWVCFNPEPSLP---------EPLPCPQEDP 1267

  Fly  1368 HLNQANGTLPLLPKKPQQ---LHGEKLFI---KNGHLIDGEALLAKTDVAMSGL------LIKLD 1420
            ||..:|..|....|....   |..||.|:   ...|.....:|...|.:..:|:      .|.:|
Human  1268 HLETSNHCLLSEGKSDSSSICLSAEKSFLCFAPESHPEVSASLRVATSLGFAGMNEMVAPRIGMD 1332

  Fly  1421 QVAAQCSVAQAAGGGTSIDEEKFQRARNELTEQTLALVTASKFLVASMSDMTLITLPEHLTSCLT 1485
            |.:.|.|.|....|.....||:    ..:|....:|.:|:..   ::.|.:.|...|....||.|
Human  1333 QCSCQFSYATCFRGPQPETEEE----DRDLEAHPMAPLTSPP---SAGSPVVLPWRPARAHSCTT 1390

  Fly  1486 A 1486
            |
Human  1391 A 1391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42788NP_731964.2 WW 177..203 CDD:459800
WW 218..246 CDD:238122 6/28 (21%)
PDZ_FRMPD1_3_4-like 259..333 CDD:467250 24/74 (32%)
FERM_F1_FRMPD1_like 393..482 CDD:340608 39/88 (44%)
B41 396..617 CDD:214604 91/223 (41%)
PH-like 613..715 CDD:473070 24/108 (22%)
PHA03247 <1105..1377 CDD:223021 61/292 (21%)
FRMPD1NP_055722.2 PDZ_FRMPD1_3_4-like 57..132 CDD:467250 25/78 (32%)
FERM_F1_FRMPD1 179..268 CDD:340688 42/93 (45%)
B41 182..401 CDD:214604 91/223 (41%)
FERM_C_FRMPD1_FRMPD3_FRMPD4 397..501 CDD:270004 24/108 (22%)
PHA03307 555..>827 CDD:223039 62/296 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..616 13/68 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 720..743 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 759..831 20/82 (24%)
LGNbd_FRMPD1 901..938 CDD:409273 7/38 (18%)
Important for interaction with GPSM2. /evidence=ECO:0000269|PubMed:23318951 924..931 1/8 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 950..1030 15/79 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1070..1194 27/136 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1347..1374 5/33 (15%)
Blue background indicates that the domain is not in the aligned region.

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