DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42788 and frm-8

DIOPT Version :9

Sequence 1:	NP_731964.2	Gene:	CG42788 / 41817	FlyBaseID:	FBgn0261859	Length:	1560	Species:	Drosophila melanogaster
Sequence 2:	NP_741109.1	Gene:	frm-8 / 175428	WormBaseID:	WBGene00001494	Length:	853	Species:	Caenorhabditis elegans

Alignment Length:	811	Identity:	238/811 - (29%)
Similarity:	386/811 - (47%)	Gaps:	134/811 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 GRLYYCNHMTQSAGWLPACEDWSKHEELSYGWERAIDSKGRSYYINHLNKTTTYEAPECIRWDEH 253
            ||::|.:|.|:|:.|.|....|.....|.||||:|.|:.|.:|||:|||:||||..|...|
Worm    67 GRIFYIHHTTRSSHWEPPWASWRCRLGLPYGWEQAKDNDGNTYYIDHLNRTTTYTDPRKTR---- 127

  Fly   254 PPE-PRQVQLQRNASLGFGFVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHV 317
            ||: .|.|.::|...:||||||..:.|.|::||:..|||.|.|...||||.|||.|:::..:|:|
Worm   128 PPDGKRTVSIRRGKDIGFGFVAAGQLPTIIQFVSPEGPSDGLLYANDQILEVNGLDMQNETKDNV 192

  Fly   318 IQLVRACESQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGA----PLF 378
            :..|||.:.::.:.|.|      ||          :|.|...:..:|||.:.|.|:..    ..|
Worm   193 VNAVRAAKEELQITVQQ------LP----------QRPKSSRKNCKVRFTDRVLVSSTNDNNSEF 241

  Fly   379 PPSAFSLGDICVPPMANVLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHV 443
            ||.           :.|||:|:||||||:|||||.:|||:.::.|:|:||.:.....|||.:|:.
Worm   242 PPL-----------LPNVLRVYLENGQTRSFKYDQSTTVKQILESILEKLQISAKSHFSLAVEYS 295

  Fly   444 KSLKRNKLTLLDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVN 508
            ...:.::::||.|...:..|...|.:..|||:||::|.|..|..|...|..||:|.|.||.|||.
Worm   296 LGARTSRISLLRPDCKIKSIVDLPNSEHLRCVFRLSFAPSDAFVLLLSDPKALEYYYQQCVNDVV 360

  Fly   509 QERFAPELQPELALRLAALHMHQHALANNFAPA--KLTVKLVEREFGLERFVPVSLFEGMKRKEL 571
            :.|||.|::.|..:||||||:.|.|...|....  |::|..||:|:||..|:|..:.|.:||:::
Worm   361 RGRFAMEMRYEACIRLAALHVQQVAYDCNILKENNKVSVHRVEKEYGLGTFLPAIVLENVKRRDV 425

  Fly   572 RRLISHFLKLNA------------------EMTGSSSKVLTQ--LQAKLHYLDIIASLPSYGAKC 616
            |:.|..:||.::                  |:...:::...:  :..:|.|:.|::.|||:|.:.
Worm   426 RKHIRFYLKRDSSRLVDCFGKPTIGNGYPPELEACAAQFANEPSMMVRLRYIHIVSHLPSFGGRS 490

  Fly   617 FSTNQREG-VERVLLVSPRFGLSQISSARNSVQPQPISAIEDFTHVVVNREDDVTCSVSIFMLGD 680
            |....:|. ::.::.|.||.|| .:.....|.||......:....:||.:|.:|...:||.:..:
Worm   491 FCVTFKESQIDMLMQVEPRTGL-LVRHPGKSGQPSISIGFDLIGKLVVCKETEVASMISIRLASN 554

  Fly   681 --RAVKFIMEDRDGCEFSLVLGGYYRLLTGNVLNI--------LREREPNDEDNAPGFLSQHTVL 735
              :.::|:::..|..:..:.:.||:::.....|.:        |||.    .|.||.:.:.|||:
Worm   555 PHQGLEFLVDKDDLDDLVMYIVGYHKVTYEKDLLLEIDDSPPKLREL----PDKAPPYSAIHTVV 615

  Fly   736 PAGWSYLLPFHTRAHSVNFLMAPPYHPLVQRGQLQQQSSIQAPSSLPYVMDLDLHSVMATELLEE 800
            .:.|:|        ...:.....|:.|            ...|.|  |.:......:.......|
Worm   616 KSDWNY--------SETSSQTEKPFDP------------TDGPPS--YEIANSFVQIAFENEQNE 658

  Fly   801 AAKDSGLSDSSGSNYCEGRSHLGSHQLEAKNEQVLRRVQELQHLVQTS-EQYLSEQEQGGGGGGV 864
            ...|:.:|..:|.::...|:|.       :.:::||....|  |::.| :.:..|.|...||.
Worm   659 DHFDTEISRQNGESFTPKRAHF-------EPKKLLRATDSL--LIKNSRDLHAKELEIQNGGS-- 712

  Fly   865 AMLEFDSDCDSLNSSKVSSTEG------SQGGTILGPGAIIPPG-------------HPLKHSDS 910
               :.|...|:.:||..|....      ..|..:|..|   ||.             :|..:.:|
Worm   713 ---QNDESSDTEDSSFSSPLRSPNIDRLCDGINLLVTG---PPARRASIETLLQNNQNPNTNLES 771

  Fly   911 LTLLAETINHELSGITQGLNAIPESAPVSTS 941
            |.|...||..| :.:.....|:||....||:
Worm   772 LILQFPTIPDE-NEVENDDVALPEGMQTSTT 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809	6/13 (46%)
		WW	218..246	CDD:238122	17/27 (63%)
		PDZ_signaling	257..333	CDD:238492	31/75 (41%)
		B41	396..617	CDD:214604	87/242 (36%)
		UBQ	396..477	CDD:294102	33/80 (41%)
		FERM_M	495..617	CDD:278785	47/143 (33%)
		PH-like	613..715	CDD:302622	22/112 (20%)
frm-8	NP_741109.1	WW	<65..84	CDD:278809	7/16 (44%)
		WW	95..124	CDD:238122	17/28 (61%)
		PDZ_signaling	133..208	CDD:238492	31/74 (42%)
		B41	248..491	CDD:214604	87/242 (36%)
		FERM_N	251..>293	CDD:286467	22/41 (54%)
		FERM_M	342..491	CDD:278785	48/148 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167049
Domainoid	1	1.000	80	1.000	Domainoid score	I5588
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6135
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007172
OrthoInspector	1	1.000	-	-		oto18490
orthoMCL	1	0.900	-	-		OOG6_112832
Panther	1	1.100	-	-	LDO	PTHR10316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4089
SonicParanoid	1	1.000	-	-		X1331
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.820