DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42788 and Magi2

DIOPT Version :9

Sequence 1:	NP_731964.2	Gene:	CG42788 / 41817	FlyBaseID:	FBgn0261859	Length:	1560	Species:	Drosophila melanogaster
Sequence 2:	NP_446073.2	Gene:	Magi2 / 113970	RGDID:	621855	Length:	1277	Species:	Rattus norvegicus

Alignment Length:	1284	Identity:	239/1284 - (18%)
Similarity:	390/1284 - (30%)	Gaps:	539/1284 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 NGSVVHATPTRSN--GCPLTQSSGIPVTMATTATAMATATPDPSG------------CTEVEGTA 125
            :|:::.:.....|  |.|...:...|:.:..|...:..|||...|            ...:|...
  Rat   169 SGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVTNMEKASIEPPE 233

  Fly   126 STELSTGLANETNCGTGIYGPLLGQSHGGVIAGMTENWPE------IDGHLEAIQEKL------K 178
            ..|....:.|    |.|:........|....||.:...|.      :....|.:::::      |
  Rat   234 EEEEERPVVN----GNGVVITPESSEHEDKSAGASGETPSQPYPAPVYSQPEELKDQMDDTKSTK 294

  Fly   179 P-----------GWSVHVGKEGRLYYCNHMTQSAGWL---------PACEDWSKHEELSYGWERA 223
            |           .|.:...::|.:|:.:|.|::..||         ||.|  .|..||.||||:.
  Rat   295 PEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPAEE--CKENELPYGWEKI 357

  Fly   224 IDSKGRSYYINHLNKTTTYEAP--ECIR---------------------WDEHPPEPRQV-QLQ- 263
            .|....:||::|:|:.|.:|.|  |..|                     :.|.|...|.. ||:
  Rat   358 DDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKG 422

  Fly   264 -------RNASLGFGF-VAGSERP---VIVRFVTEGGPSI--GKLQPGDQILAVNGEDVKDAPRD 315
                   :.:::|||| :.|.:.|   :.|:.|...||:.  ||::.||.|:.:|...|......
  Rat   423 TFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHA 487

  Fly   316 HVIQLVRACE--SQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPL- 377
            .|::|.::..  ..|||::|:                                       |.||
  Rat   488 DVVKLFQSVPIGQSVNLVLCR---------------------------------------GYPLP 513

  Fly   378 FPPS--AFSLGDICVPPMANVLK--VFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSL 438
            |.|.  |.|:    |||:|.:.:  ..:.||:..                            :..
  Rat   514 FDPEDPANSM----VPPLAIMERPPPVMVNGRHN----------------------------YET 546

  Fly   439 VLEHVKSLKRNKLTLLDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQC 503
            .||::..          ..:|:..|..|| .|.|..:      |...         .||..|...
  Rat   547 YLEYISR----------TSQSVPDITDRP-PHSLHSM------PADG---------QLDGTYPPP 585

  Fly   504 CNDVNQERFAPELQPELALRLAALHMHQHALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKR 568
            .:|.|
  Rat   586 VHDDN------------------------------------------------------------ 590

  Fly   569 KELRRLISHFLKLNAEMTGSSSKVLTQLQAKLHYLDIIASLPSYGAKCFSTNQREGVERVLLVSP 633
                        ::...:|::       ||:|..|.|:.....:|.....:...:.|:::|.:..
  Rat   591 ------------VSVASSGAT-------QAELMTLTIVKGAQGFGFTIADSPTGQRVKQILDIQG 636

  Fly   634 RFGLSQ----ISSARNSVQPQPISAIEDFTHVVVNREDDVTCSVSIFMLGDRAVKFIMEDRDGCE 694
            ..||.:    :...:.:||        :.:|..|           :.:|.|..|        |.|
  Rat   637 CPGLCEGDLIVEINQQNVQ--------NLSHTEV-----------VDILKDCPV--------GSE 674

  Fly   695 FSLVL--GGYY------RLLTGNVLNILREREPNDEDNAPGFLSQHTVLPAGWSYLLPFHTRAHS 751
            .||::  ||::      :.:.....|   :..|....:||       .:|..    |||....|.
  Rat   675 TSLIIHRGGFFSPWKTPKPMVDRWEN---QGSPQTSLSAP-------AVPQS----LPFPPALHR 725

  Fly   752 VNF---------LMAPPYHPLVQ-------RGQLQQQSSIQAPSSLPYVMDLDLH-----SVMAT 795
            .:|         ....||....:       |.|:..::|.:..||.|...:||:|     |....
  Rat   726 SSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGF 790

  Fly   796 ELL--EEAAKD--SGLSDSSGSNYCEGRSHLG--------------SHQL-------EAKNEQVL 835
            .:|  :|..:.  .|...:.||...:||.|.|              :|:.       .|:|.||.
  Rat   791 RILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVN 855

  Fly   836 RRVQE---------------------------------------------------LQHLVQTSE 849
            ..|:.                                                   ..|.:|||:
  Rat   856 LTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYANSNHAAPSSNASPPEGFASHSLQTSD 920

  Fly   850 QYLSEQEQGGGGGGVAMLEFDSDCDSLNSSKVSSTEGSQGGTILGP---GAIIPPGHP------- 904
            ..:..:|..|.|..:        ..|||..:       .|.||..|   |.|| .|.|
  Rat   921 VIIHRKENEGFGFVI--------ISSLNRPE-------SGATITVPHKIGRII-DGSPADRCAKL 969

  Fly   905 ----------------LKHSDSLTLLAETINHELSGITQGLNAIPE-------SAPVSTS----- 941
                            :.|:|.:.|:.:      :|::..|..||:       |||.|..
  Rat   970 KVGDRILAVNGQSIINMPHADIVKLIKD------AGLSVTLRIIPQEELNSPTSAPSSEKQSPMA 1028

  Fly   942 -------------APPTPATPKRKPSLCSTSSPRPQRKLNGFSQLLSDLQALGTDFS-QSESDSE 992
                         |.|:||||  ...:...:.|:|             ||..|.:.| :||..:.
  Rat  1029 QQHSPLAQQHSPLAQPSPATP--NSPVAQPAPPQP-------------LQLQGHENSYRSEVKAR 1078

  Fly   993 SVASP--AQSPTT--RRPQMMLLQAAGSSAGSVAPAKQQLSQRSSFGLHSPDGTHFGAETKDYNL 1053
            ....|  .|.|.|  |:|.:...|..|......:|    |..|.    ||||       |:.|.|
  Rat  1079 QDVKPDIRQPPFTDYRQPPLDYRQPPGGDYSQPSP----LDYRQ----HSPD-------TRQYPL 1128

  Fly  1054 REYLQQLKEISNAASADTDVAARQLSEIYGFEVREDTFIETDTDLIDLR 1102
            .:|.|  .:..:..:.|.:..|:.    :||.:|...  |...||..||
  Rat  1129 SDYRQ--PQDFDYFTVDMEKGAKG----FGFSIRGGR--EYKMDLYVLR 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809	7/42 (17%)
		WW	218..246	CDD:238122	12/29 (41%)
		PDZ_signaling	257..333	CDD:238492	25/92 (27%)
		B41	396..617	CDD:214604	23/222 (10%)
		UBQ	396..477	CDD:294102	10/82 (12%)
		FERM_M	495..617	CDD:278785	12/121 (10%)
		PH-like	613..715	CDD:302622	19/113 (17%)
Magi2	NP_446073.2	PDZ_signaling	22..96	CDD:238492
		GuKc	118..291	CDD:214504	20/125 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..308		16/106 (15%)
		Interaction with DDN. /evidence=ECO:0000250	302..381		25/80 (31%)
		WW	304..333	CDD:395320	7/28 (25%)
		WW	350..381	CDD:197736	13/30 (43%)
		PDZ	428..509	CDD:214570	23/119 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..575		7/25 (28%)
		PDZ	602..683	CDD:214570	19/107 (18%)
		MAGI_u5	687..758	CDD:406953	13/84 (15%)
		PDZ	775..861	CDD:214570	19/85 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..913		0/43 (0%)
		PDZ_signaling	920..1007	CDD:238492	20/108 (19%)
		PRK10263	<1007..>1135	CDD:236669	40/159 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1130		36/148 (24%)
		PDZ_signaling	1140..1220	CDD:238492	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10316
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010