DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42788 and frmpd1b

DIOPT Version :9

Sequence 1:	NP_731964.2	Gene:	CG42788 / 41817	FlyBaseID:	FBgn0261859	Length:	1560	Species:	Drosophila melanogaster
Sequence 2:	XP_009305963.1	Gene:	frmpd1b / 101882587	ZFINID:	ZDB-GENE-140328-1	Length:	1656	Species:	Danio rerio

Alignment Length:	1339	Identity:	345/1339 - (25%)
Similarity:	534/1339 - (39%)	Gaps:	328/1339 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 WLPACEDWSKHEELSYGWERAIDSKGRSYYINHLNKTTTYEAPECIRWDEHPPEPRQVQLQRNAS 267
            ||....|....|.:..|........|:..:                      |....|::.|:|.
Zfish    25 WLRRSRDSLSRERILRGRRSRSGDSGQQNF----------------------PVKVTVEVIRDAV 67

  Fly   268 L-GFGFVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHVIQLVRACESQVNLL 331
            | ..||...:::|::||.:|.|||:.|.|.||||||.||.:.:.|...::..|::|.|:..|.:.
Zfish    68 LNSHGFTLSTQQPLLVRDITPGGPADGHLFPGDQILKVNNKAIDDLSPENAEQMIRDCQDSVTMT 132

  Fly   332 VCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNG-----APLFPPSAFSLGDICVP 391
            :.:.|.:     .||:.::|.|||:||..|.:|||||.|.|||     :.||.|
Zfish   133 ILRNMTN-----PKSSFITAEKRARLRRNPVKVRFAEEVVVNGHTQGNSLLFLP----------- 181

  Fly   392 PMANVLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRNKLTLLDP 456
               |||||:|||||||:||:..||||:|:|.:|.:||.:.|.|.|:||||...::  :||.||..
Zfish   182 ---NVLKVYLENGQTKAFKFHKTTTVKDIVLTLKEKLSIRCIEHFALVLEQQYNI--SKLLLLHD 241

  Fly   457 QESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAPELQPELA 521
            :|.:.::..:..:|..|||||:.|:|....||.|.|..|.:||:.|...||.:||:|.|::...|
Zfish   242 EELIQKVVQKKDSHDYRCLFRVCFIPRDPVELMQDDPMAFEYLFQQSVGDVLKERYAVEMKCNTA 306

  Fly   522 LRLAALHMHQHALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLISHFLKLNAEMT 586
            |||||||||: .||:.....:.:||.|.:|||||.|:..:|...|:.|:||:.::|.:|....:.
Zfish   307 LRLAALHMHE-KLASCGQTMRASVKSVVKEFGLESFISPTLLRNMREKDLRKALNHHMKKIQALL 370

  Fly   587 GSSSKVLTQLQAKLHYLDIIASLPSYGAKCFST----NQREGVERVLLVSPRFGLSQISSARNSV 647
            ....||::..||:|.||..:|.|.||..:.::.    ..||.:.. |||..|:|:|||.:.
Zfish   371 EPRQKVISVSQARLAYLTQMAELISYSGRSYNATMLLQDRESLVS-LLVGARYGISQILNH---- 430

  Fly   648 QPQPISAIEDF---THVVVNREDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVLGGYYRLLTGN 709
            |...||.|.||   |.:.|..|.|....|.|::...:.:..:||.....:.:.:|.||.:||...
Zfish   431 QLNMISTIIDFHYITRIEVLSESDRVSMVKIYLQDIQPIALLMESVGAKDLACLLAGYCKLLVDP 495

  Fly   710 VLNILR----------------------EREPNDEDN--APGF----LSQHTVLPAGWSYLLPFH 746
            .:|:.|                      :.|.:.||:  ..|.    ||:.|:         ..|
Zfish   496 NINVFRWGPRPKMRRIPAEEGYVSRCGSDSEDSSEDDYAMEGLLDTQLSEDTI---------STH 551

  Fly   747 T--------------RAHSVNFLMAPPYHPLVQRGQLQQQSSIQAPSSLPYVMDLDLHSVMATEL 797
            |              .|..|..::..|:....:.|..:::|          |.|.|..:.| ..|
Zfish   552 TNDGTEDGEEPEGKGEAERVRVIVTHPFSEDEEDGASKRES----------VGDEDYAATM-DSL 605

  Fly   798 LEEAAKDSGLSDSSGSNYCEGRSHLGSHQLEAKNEQVLRRVQEL--------------------- 841
            ||.........:||.|:       |.|:.|.|..|.:...:..|
Zfish   606 LETGWYTDPRVNSSFSS-------LSSNSLNALEESIKAAISGLGRTDISLEEKPSSGASSLDVH 663

  Fly   842 -QHLVQTSEQYLSEQEQGGGGGGVAMLEFDSDCDSLNSSKVSSTEGSQGGTILGPGAIIPPGHPL 905
             .:|::..||.    ::||..|..:.|.:| |...|..|::|....|.            |..|.
Zfish   664 HPYLLEVPEQL----DKGGNSGKTSELTYD-DHSGLCFSELSQMSDSL------------PSPPA 711

  Fly   906 KHSDSLT------------------LLA----ETINHELSGIT-QGL-NAI---PESAPVSTSAP 943
            ...|:|:                  :||    .:||.:|:|:. |.| |.|   |.......|.|
Zfish   712 ASDDALSDEDDEDGRISAMSAEFEAMLASCTTNSINAKLAGVNFQALFNKIHNHPACRAEGNSFP 776

  Fly   944 PTPATPKRKPSLCSTSSPRPQRKLNGFSQLLSDLQALGT----------DFSQSESDSESVASPA 998
                            :...||.|:  |:||:....|.|          :|..|.|:||.....|
Zfish   777 ----------------NDANQRGLS--SKLLAQTVLLRTVCSNIHEKSKEFRDSCSESEDEFFDA 823

  Fly   999 QSPTTRRPQMMLLQAAGSSAGSVAPAKQQLSQRS--SFGLHSPDGTHFGAETKDYNLREYLQQLK 1061
            :...|  |.:               .:|.|:::|  |..:||....|      |..:.....:..
Zfish   824 EDRLT--PPI---------------TEQGLAEKSSDSGNMHSSLSVH------DMKVNASKTKAP 865

  Fly  1062 EISNAASADTDVAARQLSEIYGFEVREDTFI--ETDTDL-IDLRAIPPPQTPDELDSLSL----- 1118
            |..:....|. .:...|:|.........|.|  ..:||| :...::..|..|..::|.:.
Zfish   866 EFGDRKERDR-ASGGNLNENPSLANHFTTLIPESKNTDLEVHQPSLILPNKPTSVESKAFSANHS 929

  Fly  1119 --MNAAPPKG-FEGKAEELDSFLQQIMVAPPTQKATPAKELTPEEIMSFIIP-PPPNLEQQQVVA 1179
              .||....| ..|:...|.|  |.:.:.|.|.:..|.....|....|.|.. ....|.||.:|.
Zfish   930 MAQNAQHCNGDIPGQNSHLSS--QLLEMEPDTMEFKPVTGPGPAMSSSLITAVRQATLPQQTLVD 992

  Fly  1180 PVETECLYSNSVQAKREFFQSVANG---NNGTVSHSPHIIE------YATVERKSKFSCCPTSKK 1235
            |                  :::.||   .||..:|.|..:|      |..::........||.||
Zfish   993 P------------------ETLHNGPRHQNGISNHIPICLEKKTTTNYVDLDGPESKGIKPTWKK 1039

  Fly  1236 E---------EQPGQEELQPPPR-----TPTTEQL----SPPPARPPKSAELLQRYSPKKQVRIA 1282
            .         ....:..|:|...     |.|..:|    :.||..|..|...||..|     :.|
Zfish  1040 PTGTIEFGKITVDSKSHLKPQSSDSTEITTTVNKLPQNNTKPPIPPKPSFIALQPSS-----KAA 1099

  Fly  1283 ASPVMQPQERRELCPPQLPPRGSPTLDGSQSSPTNAVSGPKKPPLPPIACRPRPSNGVNSPNSSS 1347
            .|...:|:|:.::.|..|........:|:.:||.:.:|.........:....:..:....|.|:|
Zfish  1100 DSQSQKPEEKTKVPPNGLSLHPWSQRNGTNTSPASTMSKGVSQSHENLRTEGKAESYTVKPTSAS 1164

  Fly  1348 PGSAPPAHYSP-PIPATVRLPHLNQANGTLPLLPKKPQQ 1385
            ....|    || |:|:    |....|:    ::|:.|.|
Zfish  1165 TTPTP----SPSPLPS----PSAQSAD----IVPEDPAQ 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809	345/1339 (26%)
		WW	218..246	CDD:238122	2/27 (7%)
		PDZ_signaling	257..333	CDD:238492	28/76 (37%)
		B41	396..617	CDD:214604	95/220 (43%)
		UBQ	396..477	CDD:294102	38/80 (48%)
		FERM_M	495..617	CDD:278785	49/121 (40%)
		PH-like	613..715	CDD:302622	30/108 (28%)
frmpd1b	XP_009305963.1	PDZ_signaling	59..134	CDD:238492	28/74 (38%)
		B41	183..387	CDD:214604	89/206 (43%)
		FERM_B-lobe	280..393	CDD:271216	46/113 (41%)
		PH-like	398..501	CDD:302622	30/107 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595605
Domainoid	1	1.000	129	1.000	Domainoid score	I5204
eggNOG	1	0.900	-	-		E1_KOG3552
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24527
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1331
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740