Protein Alignment CG42788 and frmpd1b

DIOPT Version :10

• Sequence 1: NP_731964.2
• Gene: CG42788 / 41817
• FlyBaseID: FBgn0261859
• Length: 1560
• Species: Drosophila melanogaster
• Sequence 2: XP_009305963.2
• Gene: frmpd1b / 101882587
• ZFINID: ZDB-GENE-140328-1
• Length: 1656
• Species: Danio rerio
• Alignment Length: 1361
• Identity: 349/1361 - (25%)
• Similarity: 534/1361 - (39%)
• Gaps: 372/1361 - (27%)

  Fly   203 WLPACEDWSKHEELSYGWERAIDSKGRSYYINHLNKTTTYEAPECIRWDEHPPEPRQVQLQRNAS 267
            ||....|....|.:..|........|:..:                      |....|::.|:|.
Zfish    25 WLRRSRDSLSRERILRGRRSRSGDSGQQNF----------------------PVKVTVEVIRDAV 67

  Fly   268 L-GFGFVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHVIQLVRACESQVNLL 331
            | ..||...:::|::||.:|.|||:.|.|.||||||.||.:.:.|...::..|::|.|:..|.:.
Zfish    68 LNSHGFTLSTQQPLLVRDITPGGPADGHLFPGDQILKVNNKAIDDLSPENAEQMIRDCQDSVTMT 132

  Fly   332 VCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNG-----APLFPPSAFSLGDICVP 391
            :.:.|.:     .||:.::|.|||:||..|.:|||||.|.|||     :.||.|
Zfish   133 ILRNMTN-----PKSSFITAEKRARLRRNPVKVRFAEEVVVNGHTQGNSLLFLP----------- 181

  Fly   392 PMANVLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRNKLTLLDP 456
               |||||:|||||||:||:..||||:|:|.:|.:||.:.|.|.|:||||...::  :||.||..
Zfish   182 ---NVLKVYLENGQTKAFKFHKTTTVKDIVLTLKEKLSIRCIEHFALVLEQQYNI--SKLLLLHD 241

  Fly   457 QESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAPELQPELA 521
            :|.:.::..:..:|..|||||:.|:|....||.|.|..|.:||:.|...||.:||:|.|::...|
Zfish   242 EELIQKVVQKKDSHDYRCLFRVCFIPRDPVELMQDDPMAFEYLFQQSVGDVLKERYAVEMKCNTA 306

  Fly   522 LRLAALHMHQHALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLISHFLKLNAEMT 586
            |||||||||: .||:.....:.:||.|.:|||||.|:..:|...|:.|:||:.::|.:|....:.
Zfish   307 LRLAALHMHE-KLASCGQTMRASVKSVVKEFGLESFISPTLLRNMREKDLRKALNHHMKKIQALL 370

  Fly   587 GSSSKVLTQLQAKLHYLDIIASLPSYGAKCFST----NQREGVERVLLVSPRFGLSQISSARNSV 647
            ....||::..||:|.||..:|.|.||..:.::.    ..||.:.. |||..|:|:|||.:.
Zfish   371 EPRQKVISVSQARLAYLTQMAELISYSGRSYNATMLLQDRESLVS-LLVGARYGISQILNH---- 430

  Fly   648 QPQPISAIEDF---THVVVNREDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVLGGYYRLLTGN 709
            |...||.|.||   |.:.|..|.|....|.|::...:.:..:||.....:.:.:|.||.:||...
Zfish   431 QLNMISTIIDFHYITRIEVLSESDRVSMVKIYLQDIQPIALLMESVGAKDLACLLAGYCKLLVDP 495

  Fly   710 VLNILR----------------------EREPNDEDN--APGF----LSQHTVLPAGWSYLLPFH 746
            .:|:.|                      :.|.:.||:  ..|.    ||:.|:         ..|
Zfish   496 NINVFRWGPRPKMRRIPAEEGYVSRCGSDSEDSSEDDYAMEGLLDTQLSEDTI---------STH 551

  Fly   747 T--------------RAHSVNFLMAPPYHPLVQRGQLQQQSSIQAPSSLPYVMDLDLHSVMATEL 797
            |              .|..|..::..|:....:.|..:::|          |.|.|..:.| ..|
Zfish   552 TNDGTEDGEEPEGKGEAERVRVIVTHPFSEDEEDGASKRES----------VGDEDYAATM-DSL 605

  Fly   798 LEEAAKDSGLSDSSGSNYCEGRSHLGSHQLEAKNEQVLRRVQEL--------------------- 841
            ||.........:||.|:       |.|:.|.|..|.:...:..|
Zfish   606 LETGWYTDPRVNSSFSS-------LSSNSLNALEESIKAAISGLGRTDISLEEKPSSGASSLDVH 663

  Fly   842 -QHLVQTSEQYLSEQEQGGGGGGVAMLEFDSDCDSLNSSKVSSTEGSQGGTILGPGAIIPPGHPL 905
             .:|::..||.    ::||..|..:.|.:| |...|..|::|....|.            |..|.
Zfish   664 HPYLLEVPEQL----DKGGNSGKTSELTYD-DHSGLCFSELSQMSDSL------------PSPPA 711

  Fly   906 KHSDSLT------------------LLA----ETINHELSGIT-QGL-NAI---PESAPVSTSAP 943
            ...|:|:                  :||    .:||.:|:|:. |.| |.|   |.......|.|
Zfish   712 ASDDALSDEDDEDGRISAMSAEFEAMLASCTTNSINAKLAGVNFQALFNKIHNHPACRAEGNSFP 776

  Fly   944 PTPATPKRKPSLCSTSSPRPQRKLNGFSQLLSDLQALGT----------DFSQSESDSESVASPA 998
                            :...||.|:  |:||:....|.|          :|..|.|:||.....|
Zfish   777 ----------------NDANQRGLS--SKLLAQTVLLRTVCSNIHEKSKEFRDSCSESEDEFFDA 823

  Fly   999 QSPTTRRPQMMLLQAAGSSAGSVAPAKQQLSQRS--SFGLHSPDGTH-------------FG-AE 1047
            :...|  |.:               .:|.|:::|  |..:||....|             || .:
Zfish   824 EDRLT--PPI---------------TEQGLAEKSSDSGNMHSSLSVHDMKVNASKTKAPEFGDRK 871

  Fly  1048 TKDYNLREYLQQLKEISN------AASADTDVAARQLSEIYGFEVREDTFIETDTDLIDLRAIPP 1106
            .:|......|.:...|:|      ..|.:||:...|.|.|                      :|.
Zfish   872 ERDRASGGNLNENPSIANHFTTLIPESRNTDLEVHQPSLI----------------------LPN 914

  Fly  1107 PQTPDELDSLSLMNAAPPKG------FEGKAEELDSFLQQIMVAPPTQKATPAKELTPEEIMSFI 1165
            ..|..|..:.|..::...|.      ..|:...|.|  |.:.:.|.|.:..|.....|....|.|
Zfish   915 KPTSVESKAFSANHSMAQKAQHCNGDIPGQNSHLSS--QLLEMEPDTMEFKPVTGPGPAMSSSLI 977

  Fly  1166 IP-PPPNLEQQQVVAPVETECLYSNSVQAKREFFQSVANG---NNGTVSHSPHIIE------YAT 1220
            .. ....|.||.:|.|                  :::.||   .||..:|.|..:|      |..
Zfish   978 TAVRQATLPQQTLVDP------------------ETLHNGPRHQNGISNHIPICLEKKTTTNYVD 1024

  Fly  1221 VERKSKFSCCPTSKKE---------EQPGQEELQPPPR-----TPTTEQL----SPPPARPPKSA 1267
            ::........||.||.         ....:..|:|...     |.|..:|    :.||..|..|.
Zfish  1025 LDGPESKDIKPTWKKPTGTIEFGKIPVDSKSHLKPQSSDSTEITTTVNKLPQNNTKPPIPPKPSF 1089

  Fly  1268 ELLQRYSPKKQVRIAASPVMQPQERRELCPPQLPPRGSPTLDGSQSSPTNAVSGPKKPPLPPIAC 1332
            ..||..|     :.|.|...:|:|:     .::||.|......||.:.||  :.|..
Zfish  1090 IALQPSS-----KAADSQSQKPEEK-----TKVPPNGLSLYPWSQRNGTN--TSPAS-------- 1134

  Fly  1333 RPRPSNGVNS--PNSSSPGSA------PPAHYSPPIPATVRLPHLNQANGTLPLLPKKPQQ 1385
              ..|.||:.  .|..:.|.|      |.:..:.|.|:...||  :.:..:..::|:.|.|
Zfish  1135 --TMSKGVSQSHENLRTEGKAESYTVKPTSASTTPTPSPSPLP--SPSAQSADIVPEDPAQ 1191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:459800	349/1361 (26%)
		WW	218..246	CDD:238122	2/27 (7%)
		PDZ_FRMPD1_3_4-like	259..333	CDD:467250	28/74 (38%)
		FERM_F1_FRMPD1_like	393..482	CDD:340608	42/88 (48%)
		B41	396..617	CDD:214604	95/220 (43%)
		PH-like	613..715	CDD:473070	30/108 (28%)
		PHA03247	<1105..1377	CDD:223021	67/313 (21%)
frmpd1b	XP_009305963.2	None