Protein Alignment CG42788 and frmpd3

DIOPT Version :9

• Sequence 1: NP_731964.2
• Gene: CG42788 / 41817
• FlyBaseID: FBgn0261859
• Length: 1560
• Species: Drosophila melanogaster
• Sequence 2: XP_002940454.2
• Gene: frmpd3 / 100489318
• XenbaseID: XB-GENE-994486
• Length: 1635
• Species: Xenopus tropicalis
• Alignment Length: 1712
• Identity: 413/1712 - (24%)
• Similarity: 626/1712 - (36%)
• Gaps: 511/1712 - (29%)

  Fly   258 RQVQLQRNASLGFGFVAGSERPVIVRFVTEGGPSIGKLQPGDQILAVNGEDVKDAPRDHVIQLVR 322
            |||.:.|....||||||||.|||:||.|..||||..||..||||||:|.|||.:|.|:..|:|||
 Frog    17 RQVTIIRRPGAGFGFVAGSARPVVVRSVIAGGPSENKLLAGDQILAINQEDVSEASRERFIELVR 81

  Fly   323 ACESQVNLLVCQPMAHCVLPGRKSTLLSAGKRAKLRSRPSRVRFAESVCVNGAPLFPPSAFSLGD 387
            ..:..:.|.|..|  |   ...||..:||.|:.||||.|.||||:|.|.|..|   ......:.|
 Frog    82 NAKESITLTVLHP--H---QSPKSAFISAAKKEKLRSNPGRVRFSELVTVGEA---EADMLKMKD 138

  Fly   388 ICVPPM---ANVLKVFLENGQTKSFKYDATTTVQDVVSSLLDKLCLCCGELFSLVLEHVKSLKRN 449
              .||:   .|||||||||||.|||.:|..|||:||:.:|.|:|.|...:.||||||:..:.:..
 Frog   139 --SPPLLLIPNVLKVFLENGQIKSFTFDGRTTVKDVMVTLQDRLSLRHRDHFSLVLEYSATEQFR 201

  Fly   450 KLTLLDPQESLARIAARPGAHKLRCLFRITFVPISAAELAQRDLHALDYLYLQCCNDVNQERFAP 514
            |..||..:..||.:..|.....:|||||:.|.|....|:...|..|.:|||:|..|||.::|...
 Frog   202 KFLLLQDKLPLAHVVHRTHYQGMRCLFRVCFFPKDPVEILHTDPAAFEYLYIQSRNDVIRDRLGT 266

  Fly   515 ELQPELALRLAALHMHQHALANNFAPAKLTVKLVEREFGLERFVPVSLFEGMKRKELRRLISHFL 579
            ||:|||.|.|.|||:: .:::::....|::::.||:|:||:.|:|.:|.:|.|.|.||:.::..|
 Frog   267 ELKPELLLVLTALHIY-ISVSSSRPGQKISLRAVEKEWGLDPFLPPALLQGYKEKSLRKALAQNL 330

  Fly   580 KLNA-EMTGSSSKVLTQLQAKLHYLDIIASLPSYGAKCFST--NQREGVERVLLVSPRFGLSQIS 641
            |::. :::||.:.|   |||||.||.|:..:|::....|:|  ...:.....|||.||.|:|.:.
 Frog   331 KIHQNQLSGSKASV---LQAKLRYLRILNEVPTFAGVLFNTVAMDEKTQATTLLVGPRHGISHVI 392

  Fly   642 SARNSVQPQPISAIEDFTH---VVVNREDDVTCSVSIFMLGDRAVKFIMEDRDGCEFSLVLGGYY 703
            ..|.::    .:.:.:||.   |.:.||......|.|.:...:|:..:||..:...||.::.|||
 Frog   393 DLRTNL----TTVLFEFTQVSKVQLFRESQGVARVEISVTDTKALVLLMEWPEATTFSCLVAGYY 453

  Fly   704 RLLTGNVLNILREREPNDEDNAPGFLSQHTVLPAGWSYLLPFHTRAHSVNFLMAPPYHPLVQRGQ 768
            |||.               |:..|...:    .||  :|.|...:|..::.       |.|.|
 Frog   454 RLLV---------------DSKKGIFYR----AAG--HLPPQIIKADRLSL-------PTVSR-- 488

  Fly   769 LQQQSSIQAPSSLPYVMDLDLHSVMATELLEEAAKDSGLSDSSGSNYC----------------- 816
              ..|||:||.|.....:.. ||...|     :.....|.||...:.|
 Frog   489 --MPSSIKAPPSSSTSSERP-HSKGPT-----STSSVPLEDSEPVSLCYLNLRVKEGRDVNQNLV 545

  Fly   817 --EGRSHLGSHQLE--AKNEQVLRRVQELQHLVQT-----SEQYLSEQEQ--------------G 858
              |||....|....  :.::.|:...:|...:.::     ..|...|..|              |
 Frog   546 TEEGRPRTKSDPTPKVSSSQPVMEEHREPSEVSRSRSFTMDTQVKGESSQFYCDSCKAKMKSRLG 610

  Fly   859 GGGGGVAMLEFDSDCDSLN--------------------------SSKVSSTEGSQGGT--ILGP 895
            ||||||   :..:.|.|.|                          ..|.|:||.....|  :|..
 Frog   611 GGGGGV---KCANTCGSSNCRDNTVDLMSLPPPELEKGEEEQEEKEGKGSATEMEVASTTALLPA 672

  Fly   896 GAIIPPGH-----------------------PLKHSDSL---------TLL-----------AET 917
            .|..|||.                       |.|..|:|         ||:           |..
 Frog   673 AAPPPPGFGDNSSDEDEPKQKIGKVQEKIKGPEKSRDALQPGYEDLPVTLIDSVQTRTVRDHARE 737

  Fly   918 INHELSGITQGLNAIPESAPVSTSAP-PTPA-------TPK------------------------ 950
            ::..|....|.|.|:..|....|.|| ||..       ||:
 Frog   738 LDDALVSTLQALEALAASEDFPTPAPQPTTGLIVLAAITPESSLDSGHETNSSELTDVSEMVTAM 802

  Fly   951 --------------RKPSL--------------------------CSTSSPRPQRKLNGFSQLLS 975
                          .|.||                          |..:||..:      |.:|.
 Frog   803 KQHHNTTYILAHHLNKESLLSRKDLPFRIQTCAAQAVLASPYTLGCQETSPLVK------STILQ 861

  Fly   976 DLQALGTDFSQSE-------------SDSESVASP------------------AQSPTTRRPQMM 1009
              |::.|..|:.|             .|...:|||                  :|||..:.|:.:
 Frog   862 --QSIATTVSKQEPTARSPSPLTNLNDDISKLASPVKPKEDTCGTVLIETPKSSQSPGKKSPRPI 924

  Fly  1010 LLQAAG-----------SSAGSV---------------APAKQQLSQ---------RSSFGLHSP 1039
            .:...|           ||.|::               :|...:|.|         .:..|.|
 Frog   925 RVSTEGSPFLSSSNPKMSSNGNLQCKEKDVAENTKPTDSPCHCRLPQGEQPFITLEEARNGGH-- 987

  Fly  1040 DGTHFGAETKD----------YNLREYLQQLKEISNAASADTD-VAARQLSEIYGFEVREDTF-I 1092
            |..|. :.|.|          .||.|..:.||.:......... |.|...:..:..:|.|.:| .
 Frog   988 DVLHL-SPTDDERLHAKACSARNLDEQCESLKTVEKQEIVKVQMVPAASPNFKHQKDVTEKSFKA 1051

  Fly  1093 ETDTDLIDLRAIPPPQ---TPDELDSLSLMNAAPPKGFEGKAEELDSFLQQIMVA---------P 1145
            |....|.| :::...|   .||:  |:.:....|......|.|::.:....|::|         |
 Frog  1052 EQKLPLPD-KSVKVEQKLPLPDK--SVKVEQKLPLPDKSVKVEQMSTVPGSILLAAESAKMNVKP 1113

  Fly  1146 PTQKATPAKE----LTPEEIMSFIIPPPPNLEQQQVVAPVETECLYSNSV--------------- 1191
            .||..|..|.    |||..:.....|..|...     ||.....|:|.:.
 Frog  1114 DTQTNTAPKNSERVLTPIALDECDAPAKPRAR-----APFRLRKLFSATFPTRMRRETDERQAQL 1173

  Fly  1192 ----QAKREFFQSVANGNNGTVSHSPHIIEYATVERKSKFSC-CPTSKKEEQPGQEE-------- 1243
                |.:.||.:.:.. .:|.:.:....|::|.|  ..:.|| ..:|..::.||...
 Frog  1174 RKVKQYEMEFLEELLK-PHGKIGNQRKEIQHALV--PGRCSCQLRSSPLQKVPGMSREQRRSCDC 1235

  Fly  1244 ------LQPPPRT---------PTTEQLSPPPARPPKSAEL------------------------ 1269
                  ::.||.|         |......||..|..:|:.|
 Frog  1236 KRIIRGIRIPPNTSLDQETRNRPKVHDSDPPRLRLVRSSSLESCSTEKMASCLNTCTTRTDDSIR 1300

  Fly  1270 LQRYSPK------KQVRIAASPVMQ-----------------PQERRELCPPQLPPRGSPTLDGS 1311
            .::..||      ::..|..|.|.:                 |..|.|.....:|||........
 Frog  1301 YKKLPPKLGTGEVEKNEIYTSTVSKVHKKENESNIKTKTQDVPDVREERKISAVPPRQEELFSVQ 1365

  Fly  1312 QSSP--TNAVSGPKKPPLPPIACRPRPSNGVNSPNSSSPGS-APPAHYSPPIPATVRLPHLNQAN 1373
            ...|  ..||.|.|       .|..|........:|:..|| .....||.|:..   ||.:....
 Frog  1366 TKLPEEEGAVLGDK-------CCSIRHCFNCRRCSSTEDGSERDELSYSIPMQI---LPGMRMNA 1420

  Fly  1374 GTLPLLPKK-----------PQQLHGEKLFIK----NGHLIDGEALLAKTDVAMSGLL-IKLD-- 1420
            .|.|::.:.           |.:...:::.::    .|.|....||..::.....|.. ::||
 Frog  1421 ETTPVVSQTLQVLDATVCSGPAESQTQEIDLRTATFEGSLAKVSALRGRSYSLPDGFTSVQLDTS 1485

  Fly  1421 ---QVAAQCSVAQAAGGGTSIDEEKFQRARNELTEQTLALVTASKFLVASMSDMTLITLPEHLTS 1482
               .|..||.|:..| |....|.....:.:.|||      |...:|..:......:...|:|:.:
 Frog  1486 ELLTVLRQCLVSSEA-GDPKPDTVNLSQRKLELT------VRFKEFRASCRRVAGVDKSPDHMLT 1543

  Fly  1483 CLTA----IRRITELAQDMTRHTSAPLQTRNIVLKVHDVASSFRELVGV----EIGPIG-----A 1534
            .:|:    :..:.|....:.....:..|.:.::.||.:|..::..|:..    ....:|     .
 Frog  1544 AITSSFQVLCGLIETFVKLVFVVRSEEQRQELLGKVEEVVRNYTFLIRAAEESSARTVGQSRTVV 1608

  Fly  1535 GQLALQAECLANVLATLLRSLR 1556
            ||||.|:..:|..::|..||::
 Frog  1609 GQLAKQSATVATAVSTFSRSIK 1630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42788	NP_731964.2	WW	177..203	CDD:278809
		WW	218..246	CDD:238122
		PDZ_signaling	257..333	CDD:238492	41/74 (55%)
		B41	396..617	CDD:214604	91/221 (41%)
		UBQ	396..477	CDD:294102	38/80 (48%)
		FERM_M	495..617	CDD:278785	47/122 (39%)
		PH-like	613..715	CDD:302622	28/106 (26%)
frmpd3	XP_002940454.2	PDZ_signaling	16..92	CDD:238492	41/74 (55%)
		B41	148..366	CDD:214604	91/221 (41%)
		FERM_M	243..366	CDD:278785	48/126 (38%)
		PH-like	363..464	CDD:302622	30/119 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4089
SonicParanoid	1	1.000	-	-		X1331
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940