DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6966 and Ankrd46

DIOPT Version :9

Sequence 1:	NP_001097796.1	Gene:	CG6966 / 41816	FlyBaseID:	FBgn0038286	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001344935.1	Gene:	Ankrd46 / 68839	MGIID:	1916089	Length:	228	Species:	Mus musculus

Alignment Length:	188	Identity:	51/188 - (27%)
Similarity:	82/188 - (43%)	Gaps:	25/188 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 VNSTTRTNSTPLRAACFDGHYEIVKYLVHHGADFEVANRHGHTCLMIACYKGHFRIAQYLLSLNA 173
            ||.:::|| .||..||.||.:...|.|:..|.|..:.:..|.|.|.:|..:|:..|.|.|....|
Mouse     6 VNDSSQTN-VPLLQACIDGDFTYSKRLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGA 69

  Fly   174 DVNRCSVKGNTALHDCAESGSLQILQLLLKHGATMDV-DYYGMTPLLAASVTGHMPIVEHLI--- 234
            |......:||||||.|   |.:..:|.|:.:|..:|: ::.|.|||:.|...|....|..|:
Mouse    70 DPLATDYQGNTALHLC---GHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESL 131

  Fly   235 -----------------TLPCVSRESRIHALELLGATYVDRKRDMAAALNLWRRALEE 275
                             |:.....||.:.:..||.......:..:::....|:..:|:
Mouse   132 EEQEVKGFNRGAHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFRTTWQEFVED 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6966	NP_001097796.1	Ank_2	10..112	CDD:289560	2/2 (100%)
		ANK	40..169	CDD:238125	21/59 (36%)
		ANK repeat	40..72	CDD:293786
		ANK repeat	86..113	CDD:293786	2/3 (67%)
		Ank_2	87..177	CDD:289560	24/67 (36%)
		ANK	110..234	CDD:238125	42/124 (34%)
		ANK repeat	118..146	CDD:293786	10/27 (37%)
		ANK repeat	148..179	CDD:293786	10/30 (33%)
		ANK repeat	181..210	CDD:293786	11/28 (39%)
		Ank_4	182..234	CDD:290365	19/52 (37%)
		ANK	528..>612	CDD:238125
		ANK repeat	529..573	CDD:293786
		ANK repeat	575..607	CDD:293786
Ankrd46	NP_001344935.1	ANK 1	11..40		12/29 (41%)
		ANKYR	<15..148	CDD:223738	40/135 (30%)
		ANK repeat	15..42	CDD:293786	10/26 (38%)
		ANK repeat	44..75	CDD:293786	10/30 (33%)
		ANK 2	44..74		10/29 (34%)
		ANK repeat	77..105	CDD:293786	12/30 (40%)
		ANK 3	77..103		11/28 (39%)
		ANK 4	107..138		8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900