DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6966 and FEM1A

DIOPT Version :9

Sequence 1:NP_001097796.1 Gene:CG6966 / 41816 FlyBaseID:FBgn0038286 Length:664 Species:Drosophila melanogaster
Sequence 2:NP_061178.1 Gene:FEM1A / 55527 HGNCID:16934 Length:669 Species:Homo sapiens


Alignment Length:730 Identity:342/730 - (46%)
Similarity:419/730 - (57%) Gaps:127/730 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDYKFIVFNAARDNNLAQLKATLYNKSSVEVGSLISAKVNGATPLVISCRNGHYDIVEYLLTKCR 65
            ||.:..|:|||||..|..|:..|..:|..|:..|......|.|||:|:.|.||.|:||||:.:|.
Human     1 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYLVDRCG 65

  Fly    66 ANVEQVGSVSFDGEPIEDAPPLWCAAAAGHLGIVKMLVRRGANVNSTTRTNSTPLRAACFDGHYE 130
            |:||..|||.||||.||.|||||.|:|||||.:|:.|:||||:||.|||||||||||||||||.|
Human    66 ASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLE 130

  Fly   131 IVKYLV-HHGADFEVANRHGHTCLMIACYKGHFRIAQYLLSLNADVNRCSVKGNTALHDCAESGS 194
            :|:||| .|.||.|||||||||||||:|||||..||:|||...|.|||.|.||||||||||||||
Human   131 VVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRSAKGNTALHDCAESGS 195

  Fly   195 LQILQLLLKHGATMDVDYYGMTPLLAASVTGHMPIVEHLIT------------------------ 235
            |:||||||...|.|:.|.||||||||||||||..|||:||.                        
Human   196 LEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGQEQVAGGEAQPGLPQEDPST 260

  Fly   236 ---------LPC-------------------VSRESRIHALELLGATYVDRKRDMAAALNLWRRA 272
                     .||                   .|||:.:.|||||||||||:|||:..||..||||
Human   261 SQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRA 325

  Fly   273 LEER--------AVEPPLEKKVQEPVPAYEMVREVTSVEELEEMVLDPDEMRMQALVIRQRILGP 329
            :|.|        ..|||      :.|.||:..|||.:.||||.::.||||||||||:||:|||||
Human   326 MELRHQGGEYLPKPEPP------QLVLAYDYSREVNTTEELEALITDPDEMRMQALLIRERILGP 384

  Fly   330 THPDTSYYIRFRGAHYADAGRFDRCIELWSYALTMQQKILQPLSPMTQSSLLSFAELFSFMLVEA 394
            :|||||||||:|||.|||:|.|:|||.||.|||.|||..|:||||||.||.||||||||::|.:.
Human   385 SHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSFLSFAELFSYVLQDR 449

  Fly   395 GRLLPRGRVVPPIEPDSMLTIFYKAVKEVERGLAFTLEQQKDQQHPQKQLPAADKSPSCSASSSA 459
            .   .:|.:...|....::.:..|.|:||||.|               |||   :.|..||.   
Human   450 A---AKGSLGTQIGFADLMGVLTKGVREVERAL---------------QLP---REPGDSAQ--- 490

  Fly   460 SSSSSTTLLSAHQHDCNHDPNALSRTMISAIHIGCLLSSLLDTDALSPEMRRQVMGALYRLNRLK 524
                                  .::.:...:|    |..||:....:|.........:|||.:..
Human   491 ----------------------FTKALAIILH----LLYLLEKVECTPSQEHLKHQTVYRLLKCA 529

  Fly   525 VRVRFDRTALHYACYREGTLAGRYPSCQFPSVTLAKALLEVGADPNAIDEAGNTPLHLATMQPYV 589
            .|.:...|.||.|..::.|..||||..:|||:.:.|.||:.||||::.|...|||||:|. |...
Human   530 PRGKNGFTPLHMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAA-QNNC 593

  Fly   590 EPLSHILLEGGAHLDTKNYAGETF-----ESLLAPTPMHKIIDPMKYTTLACLAARTIKKHDIRY 649
            ..:.:.|:|.|||:|..|...:|.     |.|||...|    .|..|.||.|||||.:.|:.|.|
Human   594 PAIMNALIEAGAHMDATNAFKKTAYELLDEKLLARGTM----QPFNYVTLQCLAARALDKNKIPY 654

  Fly   650 EGTVPATLYEFIELH 664
            :|.:|..|..|||||
Human   655 KGFIPEDLEAFIELH 669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6966NP_001097796.1 Ank_2 10..112 CDD:289560 55/101 (54%)
ANK 40..169 CDD:238125 91/129 (71%)
ANK repeat 40..72 CDD:293786 17/31 (55%)
ANK repeat 86..113 CDD:293786 17/26 (65%)
Ank_2 87..177 CDD:289560 66/90 (73%)
ANK 110..234 CDD:238125 95/124 (77%)
ANK repeat 118..146 CDD:293786 21/28 (75%)
ANK repeat 148..179 CDD:293786 22/30 (73%)
ANK repeat 181..210 CDD:293786 23/28 (82%)
Ank_4 182..234 CDD:290365 40/51 (78%)
ANK 528..>612 CDD:238125 34/83 (41%)
ANK repeat 529..573 CDD:293786 19/43 (44%)
ANK repeat 575..607 CDD:293786 13/31 (42%)
FEM1ANP_061178.1 ANK 1 2..31 11/28 (39%)
ANK repeat 40..72 CDD:293786 17/31 (55%)
ANK 2 40..70 16/29 (55%)
Ank_4 41..103 CDD:290365 38/61 (62%)
ANK 43..70 CDD:197603 15/26 (58%)
ANK 82..203 CDD:238125 92/120 (77%)
ANK repeat 82..113 CDD:293786 20/30 (67%)
ANK 3 82..111 19/28 (68%)
Ank_2 87..179 CDD:289560 67/91 (74%)
ANK repeat 115..147 CDD:293786 24/31 (77%)
ANK 4 115..145 22/29 (76%)
ANK repeat 149..179 CDD:293786 21/29 (72%)
ANK 5 149..178 20/28 (71%)
ANK 177..>236 CDD:238125 45/58 (78%)
ANK repeat 182..211 CDD:293786 23/28 (82%)
ANK 6 182..211 23/28 (82%)
Ank_4 183..235 CDD:290365 40/51 (78%)
ANK 7 214..243 19/28 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..278 2/37 (5%)
TPR 1 298..332 22/33 (67%)
TPR 2 390..423 24/32 (75%)
ANK 515..617 CDD:238125 38/102 (37%)
Ank_5 531..588 CDD:290568 26/56 (46%)
ANK repeat 534..578 CDD:293786 19/43 (44%)
ANK 8 534..576 19/41 (46%)
Ank_5 567..620 CDD:290568 22/53 (42%)
ANK repeat 580..611 CDD:293786 13/31 (42%)
ANK 9 580..609 12/29 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 205 1.000 Domainoid score I2933
eggNOG 1 0.900 - - E2759_KOG0508
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 601 1.000 Inparanoid score I955
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48454
OrthoDB 1 1.010 - - D133963at33208
OrthoFinder 1 1.000 - - FOG0003207
OrthoInspector 1 1.000 - - otm41455
orthoMCL 1 0.900 - - OOG6_105900
Panther 1 1.100 - - LDO PTHR24173
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4568
SonicParanoid 1 1.000 - - X856
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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