DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6966 and fem1c

DIOPT Version :9

Sequence 1:	NP_001097796.1	Gene:	CG6966 / 41816	FlyBaseID:	FBgn0038286	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_937788.2	Gene:	fem1c / 378965	ZFINID:	ZDB-GENE-031008-3	Length:	618	Species:	Danio rerio

Alignment Length:	668	Identity:	339/668 - (50%)
Similarity:	429/668 - (64%)	Gaps:	55/668 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDYKFIVFNAARDNNLAQLKATLYNKSSVEVGSLISAKVNGATPLVISCRNGHYDIVEYLLTKCR 65
            ||.|..|||||||..|..|:..|.|||..||..|::.|.||||||:::.|.||.::||:|:..|.
Zfish     1 MDLKTAVFNAARDGKLKLLQKLLENKSDREVLKLMAEKTNGATPLLMASRYGHLELVEFLMECCC 65

  Fly    66 ANVEQVGSVSFDGEPIEDAPPLWCAAAAGHLGIVKMLVRRGANVNSTTRTNSTPLRAACFDGHYE 130
            |.||..|||:||||.||.|||||.|:|||||.:|:.|:..||:||:||.||||||||||||||.:
Zfish    66 APVELGGSVNFDGEVIEGAPPLWAASAAGHLKVVQSLLGHGASVNNTTLTNSTPLRAACFDGHLD 130

  Fly   131 IVKYLVHHGADFEVANRHGHTCLMIACYKGHFRIAQYLLSLNADVNRCSVKGNTALHDCAESGSL 195
            ||:|||.|.||.|||||||||||||:|||||..|||:||...|||||.|||||||||||||||||
Zfish   131 IVRYLVEHQADLEVANRHGHTCLMISCYKGHREIAQFLLEKGADVNRRSVKGNTALHDCAESGSL 195

  Fly   196 QILQLLLKHGATMDVDYYGMTPLLAASVTGHMPIVEHLITLPCVSRESRIHALELLGATYVDRKR 260
            :|:::|||.||:|:.|.|||||||:||||||..||:.|...|......||.||||||||:||:||
Zfish   196 EIMKMLLKFGASMEKDGYGMTPLLSASVTGHTNIVDFLTAHPQTGLAERISALELLGATFVDKKR 260

  Fly   261 DMAAALNLWRRALEERAVEPPLEKKVQ--EPVPAYEMVREVTSVEELEEMVLDPDEMRMQALVIR 323
            |:..||..|:||:|.|..|....::.:  ||.|||:..|||::.|||:.::.|||:||||||:||
Zfish   261 DLLGALQYWKRAMELRHSEADCMRREEPLEPEPAYDCSREVSTAEELDGLIADPDDMRMQALLIR 325

  Fly   324 QRILGPTHPDTSYYIRFRGAHYADAGRFDRCIELWSYALTMQQKILQPLSPMTQSSLLSFAELFS 388
            :|||||.|||||||||:|||.|||:|.|:|||.||.|||.|||..|:||||||.|||||||||||
Zfish   326 ERILGPAHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQSNLEPLSPMTASSLLSFAELFS 390

  Fly   389 FMLVEAGR-LLPRGRVVPPIEPDSMLTIFYKAVKEVERGLAFTLEQQKDQQHPQKQLPAADKSPS 452
            |||.:..: ||..|     :....::.|..::|.|:||.:              || |.....|
Zfish   391 FMLQDRAKGLLGAG-----VSFQQLMEILCRSVLEIERAV--------------KQ-PRPSPDP- 434

  Fly   453 CSASSSASSSSSTTLLSAHQHDCNHDPNALSRTMISAIHIGCLLSSLLDTDALSPEMRRQVMGAL 517
                                     ||..||:.:...:|:.|||..|    ..|||..:.....:
Zfish   435 -------------------------DPAQLSKLLSIILHLICLLEKL----PCSPEQDQHKKETI 470

  Fly   518 YRLNRLKVRVRFDRTALHYACYREGTLAGRYPSCQFPSVTLAKALLEVGADPNAIDEAGNTPLHL 582
            ||..:|:...|...:.||.|.....|..||||.|:|||:.:|..|||.|||.|:.|...|:|||:
Zfish   471 YRFLKLQACGRNGFSPLHLAVDHNTTCVGRYPVCKFPSLQVASVLLECGADVNSRDLDDNSPLHV 535

  Fly   583 ATMQPYVEPLSHILLEGGAHLDTKNYAGETFESLLAPTPMHK-IIDPMKYTTLACLAARTIKKHD 646
            |....:.: :..:|:.||.|.|:.|...:|...||..|.:.| :|.|:.:|||.|||||.|.:|.
Zfish   536 AASNNHPD-IMKLLISGGTHFDSTNALQQTACDLLDHTQLAKSLIQPINHTTLQCLAARAIIRHR 599

  Fly   647 IRYEGTVPATLYEFIELH 664
            :.|.|::|..|..|:.||
Zfish   600 LVYRGSIPERLEAFVLLH 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6966	NP_001097796.1	Ank_2	10..112	CDD:289560	56/101 (55%)
		ANK	40..169	CDD:238125	87/128 (68%)
		ANK repeat	40..72	CDD:293786	16/31 (52%)
		ANK repeat	86..113	CDD:293786	15/26 (58%)
		Ank_2	87..177	CDD:289560	64/89 (72%)
		ANK	110..234	CDD:238125	93/123 (76%)
		ANK repeat	118..146	CDD:293786	21/27 (78%)
		ANK repeat	148..179	CDD:293786	23/30 (77%)
		ANK repeat	181..210	CDD:293786	22/28 (79%)
		Ank_4	182..234	CDD:290365	37/51 (73%)
		ANK	528..>612	CDD:238125	33/83 (40%)
		ANK repeat	529..573	CDD:293786	20/43 (47%)
		ANK repeat	575..607	CDD:293786	10/31 (32%)
fem1c	NP_937788.2	Ank_2	<2..62	CDD:289560	31/59 (53%)
		ANK 1	2..31		15/28 (54%)
		Ank_2	<40..112	CDD:289560	42/71 (59%)
		ANK repeat	40..75	CDD:293786	18/34 (53%)
		ANK 2	40..70		15/29 (52%)
		ANK	82..202	CDD:238125	88/119 (74%)
		ANK repeat	82..113	CDD:293786	18/30 (60%)
		ANK 3	82..111		17/28 (61%)
		Ank_2	87..178	CDD:289560	65/90 (72%)
		ANK 4	115..144		22/28 (79%)
		ANK repeat	118..146	CDD:293786	21/27 (78%)
		ANK repeat	148..179	CDD:293786	23/30 (77%)
		ANK 5	148..177		21/28 (75%)
		ANK	176..>236	CDD:238125	43/59 (73%)
		ANK 6	181..210		22/28 (79%)
		ANK repeat	181..209	CDD:293786	21/27 (78%)
		Ank_4	182..233	CDD:290365	37/50 (74%)
		ANK 7	213..243		17/29 (59%)
		TPR 1	245..279		21/33 (64%)
		TPR 2	337..370		24/32 (75%)
		ANK	481..>580	CDD:238125	38/99 (38%)
		ANK repeat	482..526	CDD:293786	20/43 (47%)
		ANK 8	482..524		19/41 (46%)
		Ank_4	483..549	CDD:290365	26/66 (39%)
		ANK 9	528..557		9/29 (31%)
		ANK repeat	528..552	CDD:293786	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2597
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10606
Inparanoid	1	1.050	604	1.000	Inparanoid score	I899
OMA	1	1.010	-	-		QHG48454
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	1	1.000	-	-		FOG0003207
OrthoInspector	1	1.000	-	-		otm26324
orthoMCL	1	0.900	-	-		OOG6_105900
Panther	1	1.100	-	-	O	PTHR24173
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4568
SonicParanoid	1	1.000	-	-		X856
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010