Protein Alignment CG6966 and fem-1

DIOPT Version :10

• Sequence 1: NP_001097796.1
• Gene: CG6966 / 41816
• FlyBaseID: FBgn0038286
• Length: 664
• Species: Drosophila melanogaster
• Sequence 2: NP_500824.1
• Gene: fem-1 / 177335
• WormBaseID: WBGene00001411
• Length: 656
• Species: Caenorhabditis elegans
• Alignment Length: 699
• Identity: 240/699 - (34%)
• Similarity: 363/699 - (51%)
• Gaps: 87/699 - (12%)

  Fly     3 YKFIVFNAARDNNLAQLKATLYNKSSVE--VGSLISAKVNGATPLVISCRNGHYDIVEYLLTKCR 65
            ::.:::|||...||.::|....|..:..  :....::..:|..||||:.||||.::||||| :..
 Worm     8 FRTVIYNAAAVGNLQRIKVFTINSRNDRQWIIDCFNSDQDGRYPLVIAARNGHANVVEYLL-EIG 71

  Fly    66 ANVEQVGSVSFDGEPIEDAPPLWCAAAAGHLGIVKMLVRR-GANVNSTTRTNSTPLRAACFDGHY 129
            |:....|.|.||.|.|:..||||.|:||||:.|||:|:.: .|:||..|.|.|||||.||:|||.
 Worm    72 ADPSVRGVVEFDNENIQGTPPLWAASAAGHIEIVKLLIEKANADVNQATNTRSTPLRGACYDGHL 136

  Fly   130 EIVKYLVHHGADFEVANRHGHTCLMIACYKGHFRIAQYLLSLNADVNRCSVKGNTALHDCAESGS 194
            :|||||:..|||..:.|||||||||||.|:....|.:.||....|||:.:.:|||||||.||||:
 Worm   137 DIVKYLLEKGADPHIPNRHGHTCLMIASYRNKVGIVEELLKTGIDVNKKTERGNTALHDAAESGN 201

  Fly   195 LQILQLLLKHGATMDVDYYGMTPLLAASVTGHMPIVEHLI-TLPCVSRESRIH---ALELLGATY 255
            ::::::|||||:.:..|..|:.||:.|:::|.:.::..|. .:|     |.||   ||:|||:|.
 Worm   202 VEVVKILLKHGSVLMKDIQGVDPLMGAALSGFLDVLNVLADQMP-----SGIHKRDALKLLGSTL 261

  Fly   256 VDRKRDMAAALNLWRRALEE--RAVEPPLEKKVQ---EPVPAYEMVREVTSVEELEEMVLDPDEM 315
            :|:|.|..:|:|.|::::|.  .|.:..|.::::   ||...||..||..::.::|.:..:.:..
 Worm   262 LDKKMDAMSAMNCWKQSMEVPLHADDLRLVREMETFFEPQEVYEYQREAQNIAQVELLDGNIEAQ 326

  Fly   316 RMQALVIRQRILGPTHPDTSYYIRFRGAHYADAGRFDRCIELWSYALTMQQKILQPLSPMTQSSL 380
            ||||||||:||||..|.|..||:|||||.|.|.|:.:||.:||.:||.:|||...||...|.::|
 Worm   327 RMQALVIRERILGGAHTDVHYYLRFRGAVYCDMGQMNRCYDLWKHALELQQKHFAPLYYGTITTL 391

  Fly   381 LSFAELFSFMLVE------AGRLLPRGRVVPPIEPDSMLTIFYKAVKEVERGLAFT----LEQQK 435
            .||.|.||..|.:      |.|.|       .:....:..:|.....|:||..|:|    ||
 Worm   392 QSFHETFSMSLNDFVNNHHANRNL-------RVRSSWVKYVFNGVCLELERAAAWTGAPLLE--- 446

  Fly   436 DQQHPQKQLPAADKSPSCSASSSASSSSSTTLLSAHQHDCNHDPNALSRTMISAIHIGCLLSSLL 500
            |.:...|:        .|..::..|.......::.|.      .|.|.|..:.:.||.
 Worm   447 DTECCGKE--------RCQHATEESEYKKLVYVAVHL------VNVLERLSLPSAHID------- 490

  Fly   501 DTDALSPEMRRQVMGALYRLNRLKVRVRFDRTALHYACYREGTLAGRYPSCQFPSVTLAKA---- 561
            |:|. ..|.:..|...:...:.|.:.:      ||:      ||..|.|......:.|.||
 Worm   491 DSDE-EKEPKADVRRLMIVCHELHIPL------LHH------TLEERIPDSNSAELGLPKAAVLE 542

  Fly   562 -LLEVGADPNAIDEAGNTPLH-LATMQPYVEPLSHILLEGGAHLDTKNYAGETFESLLAPTPM-- 622
             |||:..|.||.|:..:||:| |...:.:.:.|...||..|..|..:|..|:...:::.....
 Worm   543 QLLELDLDVNATDKNNDTPMHILLRAREFRKSLVRALLVRGTWLFARNRHGDVVLNVMKRMKALN 607

  Fly   623 HKIIDPM---KYTTLACLAARTIK----KHDIRYEGTVPATLYEFIELH 664
            |...|.:   ::.|||.|.|..::    |..:..|..:|..|..|...|
 Worm   608 HANFDDLPLGRHITLAGLVANAMRVKYPKKFVGVEEQMPLELRRFYLAH 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6966	NP_001097796.1	ANKYR	2..236	CDD:440430	105/236 (44%)
		ANK repeat	40..72	CDD:293786	15/31 (48%)
		ANK repeat	86..113	CDD:293786	15/27 (56%)
		ANK repeat	118..146	CDD:293786	17/27 (63%)
		ANK repeat	148..179	CDD:293786	16/30 (53%)
		ANK repeat	181..210	CDD:293786	16/28 (57%)
		ANKYR	<525..>612	CDD:440430	27/92 (29%)
		ANK repeat	529..573	CDD:293786	15/48 (31%)
		ANK repeat	575..607	CDD:293786	9/32 (28%)
fem-1	NP_500824.1	Ank_2	<9..77	CDD:463710	22/68 (32%)
		ANKYR	<45..242	CDD:440430	98/197 (50%)
		ANK repeat	47..86	CDD:293786	19/39 (49%)
		ANK repeat	92..120	CDD:293786	15/27 (56%)
		ANK repeat	125..153	CDD:293786	17/27 (63%)
		ANK repeat	155..186	CDD:293786	16/30 (53%)
		ANK repeat	188..212	CDD:293786	14/23 (61%)